DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and Chrne

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:XP_006532069.1 Gene:Chrne / 11448 MGIID:87894 Length:494 Species:Mus musculus


Alignment Length:555 Identity:177/555 - (31%)
Similarity:270/555 - (48%) Gaps:87/555 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVN 65
            |...|..|:.:...|......|.:.. ||..|..||:...|||....|.:|:.:.:.|:.||.:|
Mouse     1 MAGALLGALLLLTLFGRSQGKNEELS-LYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLN 64

  Fly    66 LKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI 130
            .|.:.:||:||:..:|:||:|.::.||:.||..|.|||||:|||:|||.||.||.:.|...:..:
Mouse    65 EKEETLTTSVWIGIDWHDYRLNYSKDDFAGVGILRVPSEHVWLPEIVLENNIDGQFGVAYDSNVL 129

  Fly   131 LHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI--EV 193
            ::..|.|.|.|||||:|.|.::|.|||||.|.|.:.|.|.||:...|:.  :....|..|.  ::
Mouse   130 VYEGGYVSWLPPAIYRSTCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEF--IFAVDDDGNTINKI 192

  Fly   194 GIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEP-YLDIVFNLTLRRKTLFYTVNLIIPCVGISFL 257
            .||...:..:.||.|...|.:.........|.| ..|:::.|.:|||.|||.:|:|:|||.||.|
Mouse   193 DIDTAAFTENGEWAIDYCPGMIRRYEGGSTEGPGETDVIYTLIIRRKPLFYVINIIVPCVLISGL 257

  Fly   258 SVLVFYLPSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVT 321
            .:|.::||:.: |:|.::.|::||:.|||..|:|:.||.|||:|||||:||:|.|::.||.|:..
Mouse   258 VLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNC 322

  Fly   322 IAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFV 386
            :.||||:.|:|.||..:|.::::.:::||:||. ..|..|:|....|                  
Mouse   323 VIVLNVSLRTPTTHATSPRLRQILLELLPRLLG-SSPPPEDPRTASP------------------ 368

  Fly   387 NYDSKRFSGDYGIPALPASH------RFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGL 445
                .|.:...|| .|.|..      |.:|...|....|                          
Mouse   369 ----ARRASSVGI-LLRAEELILKKPRSELVFEGQRHRH-------------------------- 402

  Fly   446 NGDISPGCCPAAAAA---AAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYV 507
                  |...|||..   .||          |.|:...::...|:|:..::::.......||..:
Mouse   403 ------GTWTAAALCQNLGAA----------APEIRCCVDAVNFVAESTRDQEATGEELSDWVRM 451

  Fly   508 AMVLDRMFLWIFAIACVVGTALIIL-----QAPSL 537
            ...||.:..|...:...||:.||.|     |.|.|
Mouse   452 GKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDL 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 81/217 (37%)
LIC 27..530 CDD:273305 166/515 (32%)
Neur_chan_memb 247..530 CDD:280999 80/292 (27%)
ChrneXP_006532069.1 LGIC_ECD_nAChR_E 49..239 CDD:349831 71/191 (37%)
Neur_chan_memb 247..474 CDD:367256 80/292 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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