Protein Alignment nAChRalpha1 and Chrnd

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_067611.2
• Gene: Chrnd / 11447
• MGIID: 87893
• Length: 520
• Species: Mus musculus
• Alignment Length: 559
• Identity: 186/559 - (33%)
• Similarity: 300/559 - (53%)
• Gaps: 84/559 - (15%)

  Fly     5 LFAAVFIALHFATGGLANPDAKRLYDDLLS--NYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |.||:.:.....:.||  .:.:||...|.:  .|::.:|||....|::.|.:.|.||.||.:...
Mouse    10 LLAALVVCALPGSWGL--NEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLISLKEV 72

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            .:.:|||||::..|.|.:|:|:.:|:|.:..|.:|.:.:|||:|||.||.||:::::.....:::
Mouse    73 EETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACNVLVY 137

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDN---IE-V 193
            .:|.|.|.||||::|.|.|.|.|||||.|.|.:||.|..|....:.| .|||..:::.   || :
Mouse   138 DSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITL-SLKQEEENNRSYPIEWI 201

  Fly   194 GIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEP--------YLDIVFNLTLRRKTLFYTVNLIIP 250
            .||.:.:..:.||:|:...|..|       .:|        :.|:.|.|.:|||.|||.:|:::|
Mouse   202 IIDPEGFTENGEWEIVHRAAKLN-------VDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVP 259

  Fly   251 CVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVT 315
            ||.|||:..||||||.|.|||.|:.||:||:.:||.||:::.:|.||:.:||:||:|||.|:|||
Mouse   260 CVLISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVT 324

  Fly   316 LSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPP 380
            :.||:.:.|||::||:|.||.::..|::.|::.|||||.:.||.:|:|
Mouse   325 MVVVICVIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPAEEDP----------------- 372

  Fly   381 DVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPS-- 443
                             |..||       :..:..:...|.||    ....|....|.:|...
Mouse   373 -----------------GPRAL-------IRRSSSLGYICKAE----EYFSLKSRSDLMFEKQSE 409

  Fly   444 --GLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKY 506
              ||...::....|.|:       |...::....||:..::|:.||..|:::::.:...:::|..
Mouse   410 RHGLARRLTTARRPPAS-------SEQVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQ 467

  Fly   507 VAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQS--QP 543
            ||..:||:.|::.....|||||.|.||  .:|:|.  ||
Mouse   468 VARTVDRLCLFVVTPVMVVGTAWIFLQ--GVYNQPPLQP 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	79/231 (34%)
		LIC	27..530	CDD:455710	174/520 (33%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
Chrnd	NP_067611.2	LGIC_ECD	29..249	CDD:475126	78/227 (34%)
		Neur_chan_memb	256..492	CDD:460753	91/287 (32%)