Protein Alignment nAChRalpha1 and Chrnb1

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_033731.3
• Gene: Chrnb1 / 11443
• MGIID: 87890
• Length: 501
• Species: Mus musculus
• Alignment Length: 568
• Identity: 201/568 - (35%)
• Similarity: 302/568 - (53%)
• Gaps: 114/568 - (20%)

  Fly     1 MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVN 65
            :|::|.....:....|.|...:....:|...|.|||:..:||.....||:.|.:||.|:|||.:|
Mouse     3 LGALLLLLGVLGTPLAPGARGSEAEGQLIKKLFSNYDSSVRPAREVGDRVGVSIGLTLAQLISLN 67

  Fly    66 LKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI 130
            .|::.|:|.|:::.||.||:|.|:|.::.|:|:|.:.:|.:||||:||.||.|||::|.:....:
Mouse    68 EKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDINVV 132

  Fly   131 LHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGI 195
            :...|.|.|:||.:|:|.|.|.|.|||||.|.|.|.|.|::||...|.   ||...|.:    |.
Mouse   133 VSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS---LKTGLDPE----GE 190

  Fly   196 DLQDYYI-------SVEWDIMRVPA--------VRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTV 245
            :.|:.||       :.:|:|:..|:        .|..|     |..:.:::|.|.:|||.|||.|
Mouse   191 ERQEVYIHEGTFIENGQWEIIHKPSRLIQLPGDQRGGK-----EGHHEEVIFYLIIRRKPLFYLV 250

  Fly   246 NLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFT 310
            |:|.||:.|:.|::.|||||.|:|||:.|.|..||:||||.||||:.:|.|||.||::.|||:||
Mouse   251 NVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFT 315

  Fly   311 MMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVL--- 372
            |:|||.||::::.|||::.|||.||:|..||:::||..||..|.::|||   ||.||.||..
Mouse   316 MVLVTFSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGLKRPK---PERDQLPEPHHSL 377

  Fly   373 ---------TDVYHL--PPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPL 426
                     ||.|.:  ||              .|:..|.|   :||.
Mouse   378 SPRSGWGRGTDEYFIRKPP--------------SDFLFPKL---NRFQ----------------- 408

  Fly   427 PSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADL-----SPTFEKPYAREMEKTIEGSRF 486
            |.|                               :|.||     .||......:|:.:.|....:
Mouse   409 PES-------------------------------SAPDLRRFIDGPTRAVGLPQELREVISSISY 442

  Fly   487 IAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQA 534
            :|:.::.::..::::|||::||||:||:|||.|.:...|||.:|.|.|
Mouse   443 MARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDA 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	85/232 (37%)
		LIC	27..530	CDD:455710	194/536 (36%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
Chrnb1	NP_033731.3	LIC	24..488	CDD:455710	195/543 (36%)
		LGIC_ECD_nAChR_B1	27..245	CDD:349825	84/229 (37%)
		Cys-loop	151..165	CDD:349825	9/13 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..382		9/22 (41%)