Protein Alignment nAChRalpha1 and Chrna7

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_031416.3
• Gene: Chrna7 / 11441
• MGIID: 99779
• Length: 502
• Species: Mus musculus
• Alignment Length: 538
• Identity: 202/538 - (37%)
• Similarity: 299/538 - (55%)
• Gaps: 48/538 - (8%)

  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNL 66
            |.:..|.....||.:   |.....:|||.:|:.|||.|.|||.|:|..|||...|.|.|::||:.
Mouse     6 GGIWLALAAALLHVS---LQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDE 67

  Fly    67 KNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAIL 131
            |||::|||:|::..|.|:.|:||..:|.||..:..|...||.|||:|||:||..::.|..|..::
Mouse    68 KNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLV 132

  Fly   132 HHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGID 196
            :.:|...:.||.|:||.|.|||.:||||.|.|.:|||||:|.|:.:||:  .|.|         |
Mouse   133 NASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQ--MQEA---------D 186

  Fly   197 LQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLV 261
            :..|..:.|||:|.:|..||||||.||:|||.|:.:.:|:||:||:|.:||:||||.||.|::||
Mouse   187 ISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLV 251

  Fly   262 FYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLN 326
            |.||:||||||||.|::|||||||.||:|||:|.||.:|||:.:|...||::|.||||||:.||.
Mouse   252 FLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLR 316

  Fly   327 VNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSK 391
            .:...|...:|..|.:.:.:......|.::||.::        :|.....|.|    :..:..|.
Mouse   317 YHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGED--------KVRPACQHKP----RRCSLASV 369

  Fly   392 RFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPA 456
            ..|...|.|....:..: :...|....||   .|.|.|..:.|               ...|.|.
Mouse   370 ELSAGAGPPTSNGNLLY-IGFRGLEGMHC---APTPDSGVVCG---------------RLACSPT 415

  Fly   457 AAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAI 521
            ..........|:...|   ::.|.:|..|:||...:.:|:.|.:..:||:.|.|:||:.|..|::
Mouse   416 HDEHLMHGTHPSDGDP---DLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSV 477

  Fly   522 ACVVGTALIILQAPSLYD 539
            ..::.|..|::.||:..:
Mouse   478 FTIICTIGILMSAPNFVE 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	98/214 (46%)
		LIC	27..530	CDD:273305	194/502 (39%)
		Neur_chan_memb	247..530	CDD:280999	92/282 (33%)
Chrna7	NP_031416.3	LIC	4..490	CDD:273305	200/531 (38%)
		Neur_chan_LBD	26..230	CDD:280998	98/214 (46%)
		Neur_chan_memb	237..486	CDD:280999	92/282 (33%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000269|PubMed:32783947	260..267		5/6 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910