Protein Alignment nAChRalpha1 and CHRNB4

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_000741.1
• Gene: CHRNB4 / 1143
• HGNCID: 1964
• Length: 498
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 238/540 - (44%)
• Similarity: 323/540 - (59%)
• Gaps: 100/540 - (18%)

  Fly    20 LANPDAKRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWN 82
            :||.:.| |.||||  :.||.||||..::|..:::|:.|.|:|||.||.:.||||||||::|||.
Human    23 VANAEEK-LMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWT 86

  Fly    83 DYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKS 147
            ||:|.||...|.||:.|.:|::.||||||||||||||.|||::.|..|:...|.|:|.|||||||
Human    87 DYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKS 151

  Fly   148 FCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVP 212
            .|:|:|:|||||:|.|.:||.|||||...:|:..:..||..|         |:..|.||||:.:|
Human   152 ACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMD---------DFTPSGEWDIVALP 207

  Fly   213 AVRNEKFYSCCEEP-YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCI 276
            ..|...    .::| |:|:.::..::||.||||:|||||||..:.|::||||||||.|||::|||
Human   208 GRRTVN----PQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCI 268

  Fly   277 SILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWV 341
            |:||:||.|.||:::|:|||||.|||:||||:|||:|||.|:|.::.||||:.|||.||.|||||
Human   269 SVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWV 333

  Fly   342 QRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASH 406
            :|.|:..||..|.::||                    .||
Human   334 KRCFLHKLPTFLFMKRP--------------------GPD------------------------- 353

  Fly   407 RFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGD----ISPGCCPAAAAAAAADLSP 467
                      |:...|.||..|.:..|.|.....|||...|:    ::|        |:||..||
Human   354 ----------SSPARAFPPSKSCVTKPEATATSTSPSNFYGNSMYFVNP--------ASAASKSP 400

  Fly   468 TFEKPYA--------------REMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWI 518
            ....|.|              :::::.:||..|||||:||.|:.:||.|||||||||:||:|||:
Human   401 AGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWV 465

  Fly   519 FAIACVVGTALIILQAPSLY 538
            |...||:||..:.|  |.|:
Human   466 FMFVCVLGTVGLFL--PPLF 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	104/217 (48%)
		LIC	27..530	CDD:273305	232/523 (44%)
		Neur_chan_memb	247..530	CDD:280999	123/300 (41%)
CHRNB4	NP_000741.1	Neur_chan_LBD	5..480	CDD:332142	236/535 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..377		6/19 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820