Protein Alignment nAChRalpha1 and CHRNB3

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 230/548 - (41%)
• Similarity: 308/548 - (56%)
• Gaps: 114/548 - (20%)

  Fly     6 FAAVFIALHF---ATGGL----ANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLID 63
            |..|.|.|..   ||.|.    .|.||  |...|...|.:.:|||.:::|.:.|..||::|||:|
Human     5 FMLVLIVLGIPSSATTGFNSIAENEDA--LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVD 67

  Fly    64 VNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTK 128
            |:.|||:||||||::|||.|:||:||||||||:.::.||||.:|||||||:.||||.:|.::|||
Human    68 VDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTK 132

  Fly   129 AILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEV 193
            .|:...|.|||.|||.|||.|.:||.:||||.|.|.||||||||||.||||..:.:
Human   133 VIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE--------- 188

  Fly   194 GIDLQDYYISVEWDIMRVPAV---RNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGIS 255
            .:|.:|::.:.||:|:....:   |.:..||     |..|.::..|||..||||:.|||||:|:|
Human   189 NVDRKDFFDNGEWEILNAKGMKGNRRDGVYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLS 248

  Fly   256 FLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            ||:|||||||||.|||:||..|:|:|||||.|::.||||.:|..:||:|:||||.|:.||||::|
Human   249 FLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIV 313

  Fly   321 TIAVLNVNFRSPVT-HRMAPWVQRLFIQILPKLLC----IERPKKEEPEEDQPPEVLTDVYHLPP 380
            |:.|:||:.||..| |.|||||:|||:|.||||||    ::|....|.||.||
Human   314 TVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQP------------ 366

  Fly   381 DVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGL 445
             |.|....:.|:
Human   367 -VVKGKVLEKKK----------------------------------------------------- 377

  Fly   446 NGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMV 510
            ...:|.|                 ||.....:||..:..|:|::|||.:.....|.:|||:||.|
Human   378 QKQLSDG-----------------EKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQV 425

  Fly   511 LDRMFLWIFAIACVVGTALIILQAPSLY 538
            |||:|||:|.|..|.|:.||...|..::
Human   426 LDRIFLWLFLIVSVTGSVLIFTPALKMW 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	106/220 (48%)
		LIC	27..530	CDD:455710	217/510 (43%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
CHRNB3	NP_000740.1	LIC	23..449	CDD:455710	222/524 (42%)