DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and CHRNB3

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_000740.1 Gene:CHRNB3 / 1142 HGNCID:1963 Length:458 Species:Homo sapiens


Alignment Length:548 Identity:230/548 - (41%)
Similarity:308/548 - (56%) Gaps:114/548 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 FAAVFIALHF---ATGGL----ANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLID 63
            |..|.|.|..   ||.|.    .|.||  |...|...|.:.:|||.:::|.:.|..||::|||:|
Human     5 FMLVLIVLGIPSSATTGFNSIAENEDA--LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVD 67

  Fly    64 VNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTK 128
            |:.|||:||||||::|||.|:||:||||||||:.::.||||.:|||||||:.||||.:|.::|||
Human    68 VDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTK 132

  Fly   129 AILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEV 193
            .|:...|.|||.|||.|||.|.:||.:||||.|.|.||||||||||.||||..:.:         
Human   133 VIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE--------- 188

  Fly   194 GIDLQDYYISVEWDIMRVPAV---RNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGIS 255
            .:|.:|::.:.||:|:....:   |.:..||     |..|.::..|||..||||:.|||||:|:|
Human   189 NVDRKDFFDNGEWEILNAKGMKGNRRDGVYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLS 248

  Fly   256 FLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            ||:|||||||||.|||:||..|:|:|||||.|::.||||.:|..:||:|:||||.|:.||||::|
Human   249 FLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIV 313

  Fly   321 TIAVLNVNFRSPVT-HRMAPWVQRLFIQILPKLLC----IERPKKEEPEEDQPPEVLTDVYHLPP 380
            |:.|:||:.||..| |.|||||:|||:|.||||||    ::|....|.||.||            
Human   314 TVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQP------------ 366

  Fly   381 DVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGL 445
             |.|....:.|:                                                     
Human   367 -VVKGKVLEKKK----------------------------------------------------- 377

  Fly   446 NGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMV 510
            ...:|.|                 ||.....:||..:..|:|::|||.:.....|.:|||:||.|
Human   378 QKQLSDG-----------------EKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQV 425

  Fly   511 LDRMFLWIFAIACVVGTALIILQAPSLY 538
            |||:|||:|.|..|.|:.||...|..::
Human   426 LDRIFLWLFLIVSVTGSVLIFTPALKMW 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 105/217 (48%)
LIC 27..530 CDD:273305 217/510 (43%)
Neur_chan_memb 247..530 CDD:280999 109/287 (38%)
CHRNB3NP_000740.1 Neur_chan_LBD 23..449 CDD:332142 222/524 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 251 1.000 Domainoid score I2107
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.830

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