Protein Alignment nAChRalpha1 and CHRNB2

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 233/534 - (43%)
• Similarity: 322/534 - (60%)
• Gaps: 61/534 - (11%)

  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV 64
            |.|.....|..|...:|.......:||.:.||  |.||:||||..|.|:.:||::.:.|:|||.|
Human     6 GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISV 70

  Fly    65 NLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKA 129
            :.:.||||||||:.|||.||:|.|.|:::..:..:.:||:||||||:||||||||.|||:..:.|
Human    71 HEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNA 135

  Fly   130 ILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG 194
            ::.:.|.:.|.|||||||.|:|:|::||||:|.|.|||.|||||...:||....:.|
Human   136 VVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVA-------- 192

  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
             .|.|:..|.||||:.:|..|||   :..:..|:||.::..:|||.||||:|||||||.|:.|::
Human   193 -SLDDFTPSGEWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAI 253

  Fly   260 LVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324
            ||||||||.|||::||||:||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.|
Human   254 LVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCV 318

  Fly   325 LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYD 389
            |||:.|||.||.|||||:.:|::.||.||.:::|:                :|......:.....
Human   319 LNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPR----------------HHCARQRLRLRRRQ 367

  Fly   390 SKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCC 454
            .:|    .|..||     |...|.|..|..||.               :..|..||.|.......
Human   368 RER----EGAGAL-----FFREAPGADSCTCFV---------------NRASVQGLAGAFGAEPA 408

  Fly   455 PAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIF 519
            |.|....:.:       |....:.:.::|.||||.|::::|..:||.|||||||||:||:|||||
Human   409 PVAGPGRSGE-------PCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIF 466

  Fly   520 AIACVVGTALIILQ 533
            ...||.||..:.||
Human   467 VFVCVFGTIGMFLQ 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	102/219 (47%)
		LIC	27..530	CDD:455710	226/504 (45%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
CHRNB2	NP_000739.1	LIC	29..479	CDD:455710	226/508 (44%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	101/214 (47%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)