DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and CHRNB1

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_000738.2 Gene:CHRNB1 / 1140 HGNCID:1961 Length:501 Species:Homo sapiens


Alignment Length:546 Identity:197/546 - (36%)
Similarity:299/546 - (54%) Gaps:72/546 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNL 66
            |::|.....:....|.|...:....||.:.|.|.|:..:||.....||:.|.:||.|:|||.:|.
Human     4 GALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNE 68

  Fly    67 KNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAIL 131
            |::.|:|.|:::.||.||:|.|:|.::.|:|:|.:.:|.:||||:||.||.|||::|.:....::
Human    69 KDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVV 133

  Fly   132 HHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGID 196
            ...|.|.|:||.||:|.|.|.|.|||||.|.|.|.|.|::||...|.|:.........:.|:.|.
Human   134 SSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIH 198

  Fly   197 LQDYYISVEWDIMRVPA--------VRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVG 253
            ...:..:.:|:|:..|:        .|..:     |....:::|.|.:|||.|||.||:|.||:.
Human   199 EGTFIENGQWEIIHKPSRLIQPPGDPRGGR-----EGQRQEVIFYLIIRRKPLFYLVNVIAPCIL 258

  Fly   254 ISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSV 318
            |:.|::.|||||.|:|||:.|.|..||:||||.||||:.:|.|||:||::.|||:|||:|||.||
Human   259 ITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSV 323

  Fly   319 VVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVD 383
            ::::.|||::.|||.||:|..||:::||..||..|.::|||   ||.|..||        ||   
Human   324 ILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPK---PERDLMPE--------PP--- 374

  Fly   384 KFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGD 448
                :.|...|| :|               .|...:...:||.....|.|    :.|.|.     
Human   375 ----HCSSPGSG-WG---------------RGTDEYFIRKPPSDFLFPKP----NRFQPE----- 410

  Fly   449 ISPGCCPAAAAAAAADLSPTFEKP-----YAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVA 508
                       .:|.||....:.|     ...|:.:.:....:||:.::.::..::::|||::||
Human   411 -----------LSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVA 464

  Fly   509 MVLDRMFLWIFAIACVVGTALIILQA 534
            ||:||:|||.|.|...|||.:|.|.|
Human   465 MVVDRLFLWTFIIFTSVGTLVIFLDA 490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 80/222 (36%)
LIC 27..530 CDD:273305 190/515 (37%)
Neur_chan_memb 247..530 CDD:280999 104/287 (36%)
CHRNB1NP_000738.2 Neur_chan_LBD 27..245 CDD:308532 80/222 (36%)
Neur_chan_memb 252..487 CDD:308533 104/288 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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