DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha1 and CHRNA3

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_000734.2	Gene:	CHRNA3 / 1136	HGNCID:	1957	Length:	505	Species:	Homo sapiens

Alignment Length:	510	Identity:	228/510 - (44%)
Similarity:	331/510 - (64%)	Gaps:	52/510 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPD 91
            ||::.|..:||.:||||.|.||.:.:...:.:|||:.|:..||||.||:|::|.||||||||||.
Human    37 RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPS 101

  Fly    92 DYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYF 156
            ||||.:.:.||::.||.|||||||||.|:::|...|||:|.:||:|.|.||||:||.|:|||.||
Human   102 DYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYF 166

  Fly   157 PFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG--IDLQDYYISVEWDIMRVPAVRNEKF 219
            |||.|.|.||||||:||...:||           :.:|  ::|:||:.|.||.|::.|..:::..
Human   167 PFDYQNCTMKFGSWSYDKAKIDL-----------VLIGSSMNLKDYWESGEWAIIKAPGYKHDIK 220

  Fly   220 YSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTV 284
            |:||||.|.||.::|.:||..||||:||||||:.||||:|||||||||.|||::||||:||||||
Human   221 YNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTV 285

  Fly   285 FFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQIL 349
            |.|::.|.||.|||.:||:|:||||||:.||||:|:|:.||||::|:|.||.|..||:.:|:.:|
Human   286 FLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLL 350

  Fly   350 PKLLCIERPKKEEPEEDQP-PEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAA 413
            |:::.:.||...|....:| |....::.:|    :.|...:||.....|             ...
Human   351 PRVMFMTRPTSNEGNAQKPRPLYGAELSNL----NCFSRAESKGCKEGY-------------PCQ 398

  Fly   414 GGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREME 478
            .|:..:|.......|:          || :.|....|.....|..:.:|  |||        |::
Human   399 DGMCGYCHHRRIKISN----------FS-ANLTRSSSSESVDAVLSLSA--LSP--------EIK 442

  Fly   479 KTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQ 533
            :.|:..::||:::|.:::.:.:::||||||||:||:|||:|.:.|::|||.:.||
Human   443 EAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	108/214 (50%)
		LIC	27..530	CDD:273305	226/505 (45%)
		Neur_chan_memb	247..530	CDD:280999	113/283 (40%)
CHRNA3	NP_000734.2	Neur_chan_LBD	30..496	CDD:332142	226/507 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910