Protein Alignment nAChRalpha1 and CHRNA1

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 204/540 - (37%)
• Similarity: 298/540 - (55%)
• Gaps: 117/540 - (21%)

  Fly    20 LANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQ----- 79
            |.:....||...|..:|:.::|||.::...:.|.:||:|.|||:|:..|||:||||.::|
Human    26 LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVD 90

  Fly    80 --------------------EWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVT 124
                                :|.||.|||||||||||..:|:|||.||.||:||||||||::.:.
Human    91 LPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIV 155

  Fly   125 IMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSD 189
            ..||.:|.:||.:.|.||||:||:|||.|.:||||||.|.||.|:|||||.:|.:     ..:||
Human   156 KFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAI-----NPESD 215

  Fly   190 NIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCC-EEPYLDIVFNLTLRRKTLFYTVNLIIPCVG 253
            .    .||.::..|.||.|......::...|||| :.|||||.::..::|..|::.||:||||:.
Human   216 Q----PDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLL 276

  Fly   254 ISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSV 318
            .|||:.||||||:|||||::|.||:|||||||.|::.|:||.||..|||:|||:||||:.|..|:
Human   277 FSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASI 341

  Fly   319 VVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLL---CIERPKKEEPEEDQPPEVLTDVYHLPP 380
            ::|:.|:|.:.|||.||.|..||:::||..:|.::   .::||.:|:
Human   342 IITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREK------------------ 388

  Fly   381 DVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGL 445
                   .|.|.|:.|..|.        |::...|        ||                |.|.
Human   389 -------QDKKIFTEDIDIS--------DISGKPG--------PP----------------PMGF 414

  Fly   446 NGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMV 510
            :                   ||..:.|   |::..|||.::||:.:|:..:..:...:|||||||
Human   415 H-------------------SPLIKHP---EVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMV 457

  Fly   511 LDRMFLWIFAIACVVGTALI 530
            :|.:.|.:|.:.|::||..:
Human   458 MDHILLGVFMLVCIIGTLAV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	103/240 (43%)
		LIC	27..530	CDD:273305	203/531 (38%)
		Neur_chan_memb	247..530	CDD:280999	97/285 (34%)
CHRNA1	XP_016858745.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920