DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha1 and Chrna2

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_659052.1	Gene:	Chrna2 / 110902	MGIID:	87886	Length:	512	Species:	Mus musculus

Alignment Length:	513	Identity:	243/513 - (47%)
Similarity:	319/513 - (62%)	Gaps:	53/513 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPD 91
            ||:..|...|||..|||.|.||.:.|:.||.::|||||:.|||:||||||::||||||||:|:|.
Mouse    38 RLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPA 102

  Fly    92 DYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYF 156
            ::|.:.:|.||||.||:|||||||||||.:.||.||||.|..||.|.|.|||||||.|.|||.:|
Mouse   103 EFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFF 167

  Fly   157 PFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYS 221
            |||:|.|.|||||||||...:||..:::|         :||:||:.|.||.|:......|.|.|.
Mouse   168 PFDQQNCKMKFGSWTYDKAKIDLEQMERT---------VDLKDYWESGEWAIINATGTYNSKKYD 223

  Fly   222 CCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFF 286
            ||.|.|.|:.:...:||..||||:||||||:.||.|:||||||||:.||||:||||:|||||||.
Mouse   224 CCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFL 288

  Fly   287 LLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPK 351
            ||:.||||.|||.:||:|:||||||:.||||:|:|:.||||:.|||.||.|..||:...:..:|:
Mouse   289 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPR 353

  Fly   352 LLCIERPKKEEPEEDQPPEVLTDVYH-LPPDVD---KFVNYDSKRFSGDYGI---PALPASHRFD 409
            .|.:.||.........|...|:..|| |..::|   :....:.:....|..|   ..||.|
Mouse   354 WLMMNRPLPPMELHGSPGLKLSPTYHWLETNMDAEEREETEEEEEEEEDENICMCAGLPDS---- 414

  Fly   410 LAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYA 474
              :.|.:..|        .||.|.....:..:||               .|:...|||
Mouse   415 --SMGVLYGH--------GSLHLRAMGPEAKTPS---------------QASEILLSP------- 447

  Fly   475 REMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIIL 532
             :::|.:||..:||.|::::|...||:|||||||||:||:|||:|.|.|.:||..:.|
Mouse   448 -QIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	116/212 (55%)
		LIC	27..530	CDD:273305	242/509 (48%)
		Neur_chan_memb	247..530	CDD:280999	121/289 (42%)
Chrna2	NP_659052.1	LIC	15..505	CDD:273305	243/513 (47%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	116/212 (55%)
		Cys-loop	160..174	CDD:349816	9/13 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1470
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8871
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810