DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and Chrna3

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_660111.3 Gene:Chrna3 / 110834 MGIID:87887 Length:499 Species:Mus musculus


Alignment Length:540 Identity:239/540 - (44%)
Similarity:340/540 - (62%) Gaps:56/540 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGSVL----FAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQL 61
            ||.||    .:.:.:.|.......|:....||:..|..:||.:||||.|.|..:.::..:.:|||
Mouse     1 MGVVLPPPPLSMLMLVLMLLPVASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQL 65

  Fly    62 IDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIM 126
            :.|:..||||.||:|::|.||||||||.|.||.||:.:.||:|.||.|||||||||||:::|...
Mouse    66 VKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDK 130

  Fly   127 TKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI 191
            |||:|.:||:|.|.||||:||.|:|||.|||||.|.|.||||||:||...:||           :
Mouse   131 TKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL-----------V 184

  Fly   192 EVG--IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGI 254
            .:|  ::|:||:.|.||.|::.|..::|..|:||||.|.||.::|.:||..||||:||||||:.|
Mouse   185 LIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLI 249

  Fly   255 SFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVV 319
            |||:|||||||||.|||::||||:|||||||.|::.|.||.|||.:||:|:||||||:.||||:|
Mouse   250 SFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIV 314

  Fly   320 VTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLP-PDVD 383
            :|:.||||::|:|.||.|..||:.:|:.:||:::.:.||  ...|||.|.  ..:.|... .:::
Mouse   315 ITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRP--TSTEEDAPK--TRNFYGAELSNLN 375

  Fly   384 KFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGD 448
            .|...|||  |...|.|           ...|...:|.......|:          || :.|...
Mouse   376 CFSRADSK--SCKEGYP-----------CQDGTCGYCHHRRVKISN----------FS-ANLTRS 416

  Fly   449 ISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDR 513
            .|.....|..:.:|  |||        |:::.|:..::||:::|.::..:.:::||||||||:||
Mouse   417 SSSESVDAVLSLSA--LSP--------EIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDR 471

  Fly   514 MFLWIFAIACVVGTALIILQ 533
            :|||:|.:.|::|||.:.||
Mouse   472 IFLWVFILVCILGTAGLFLQ 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 109/216 (50%)
LIC 27..530 CDD:273305 231/505 (46%)
Neur_chan_memb 247..530 CDD:280999 117/283 (41%)
Chrna3NP_660111.3 LIC 24..490 CDD:273305 232/514 (45%)
LGIC_ECD_nAChR_A3 29..235 CDD:349817 109/216 (50%)
Cys-loop 153..167 CDD:349817 10/13 (77%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I2060
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 476 1.000 Inparanoid score I1470
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm8871
orthoMCL 1 0.900 - - OOG6_101158
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2381
SonicParanoid 1 1.000 - - X294
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1413.910

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