Protein Alignment nAChRalpha1 and Chrnb3

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_775304.1
• Gene: Chrnb3 / 108043
• MGIID: 106212
• Length: 464
• Species: Mus musculus
• Alignment Length: 553
• Identity: 231/553 - (41%)
• Similarity: 318/553 - (57%)
• Gaps: 117/553 - (21%)

  Fly     6 FAAVFIALH----------FATGGLA----NPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGL 56
            |..||:||.          .||.||:    :.||  |...|...|.:.:|||.|:||.:.|..||
Mouse     4 FLRVFLALSATLSGSWVTLTATAGLSSVAEHEDA--LLRHLFQGYQKCVRPVLNSSDIIKVYFGL 66

  Fly    57 RLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNY 121
            ::|||:||:.|||:||||||::|||.|.||:|||:||||::::.||||.:|||||||:.||||.:
Mouse    67 KISQLVDVDEKNQLMTTNVWLKQEWTDQKLRWNPEDYGGINSIKVPSESLWLPDIVLFENADGRF 131

  Fly   122 EVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTA 186
            |.::|||||:..:|.|.|.|||.|||.|.:||.:||||:|.|.||||||||||.||||..:.:
Mouse   132 EGSLMTKAIVKSSGTVSWTPPASYKSSCTMDVTFFPFDKQNCSMKFGSWTYDGTMVDLILINE-- 194

  Fly   187 DSDNIEVGIDLQDYYISVEWDIMRVPAV---RNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLI 248
                   .:|.:|::.:.||:|:....:   |.|.|||     |..:.::..|||..||||:.||
Mouse   195 -------NVDRKDFFDNGEWEILNAKGMKGNRREGFYS-----YPFVTYSFVLRRLPLFYTLFLI 247

  Fly   249 IPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMML 313
            |||:|:|||:|||||||||.|||:||..|:|:|||||.|::.||||.:|..:||:|:||||.|:.
Mouse   248 IPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIF 312

  Fly   314 VTLSVVVTIAVLNVNFRSPVT-HRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYH 377
            ||||::||:.|:||:.||..| |.|||||:|||::.||:.||::.|:
Mouse   313 VTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLEKLPRWLCMKDPR------------------ 359

  Fly   378 LPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSP 442
                 |:|                                           |.|     |...|.
Mouse   360 -----DRF-------------------------------------------SFP-----DGTESK 371

  Fly   443 SGLNGDISPGCCPAAAAAAAADLSPTF--EKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWK 505
            ..:.|.. ||         ....:||.  |:.....:||..|..|:|::|||.:.....|.:|||
Mouse   372 GTVRGKF-PG---------KKKQTPTSDGERVLVAFLEKASESIRYISRHVKKEHFISQVVQDWK 426

  Fly   506 YVAMVLDRMFLWIFAIACVVGTALIILQAPSLY 538
            :||.||||:|||:|..|.|:|:.||.:.|..::
Mouse   427 FVAQVLDRIFLWLFLTASVLGSVLIFIPALKMW 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	107/217 (49%)
		LIC	27..530	CDD:273305	217/508 (43%)
		Neur_chan_memb	247..530	CDD:280999	107/285 (38%)
Chrnb3	NP_775304.1	LIC	6..455	CDD:273305	229/545 (42%)
		Neur_chan_LBD	35..239	CDD:280998	108/219 (49%)
		Neur_chan_memb	246..452	CDD:280999	108/286 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..387		4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830