Protein Alignment nAChRalpha1 and LOC101882637

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_021324910.1
• Gene: LOC101882637 / 101882637
• -ID: -
• Length: 540
• Species: Danio rerio
• Alignment Length: 531
• Identity: 182/531 - (34%)
• Similarity: 277/531 - (52%)
• Gaps: 62/531 - (11%)

  Fly    25 AKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWN 89
            |.:|..||..||...:|||.:.::.:.|.:.:.|||:||::.:|||:||.:|:.|.|.|..|.||
Zfish    50 AFKLLKDLFVNYTSALRPVEDTNNIINVTLQITLSQIIDMDERNQILTTYLWIRQVWFDAYLTWN 114

  Fly    90 PDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVE 154
            ..||.|:||:.:||.::|.||:|||||||..:..::.|..::.|.|:::|..|||.||.|::||.
Zfish   115 TTDYDGLDTIRIPSSYVWRPDVVLYNNADDQFSSSMETNVVIRHDGQIMWDQPAITKSSCKVDVS 179

  Fly   155 YFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKF 219
            :||||.|.|.:.|||||::|..:||.:...:|         ||.|:..:|||::..:||.:|...
Zfish   180 FFPFDVQHCRLTFGSWTHNGNQMDLHNALDSA---------DLADFVENVEWEVQGMPAKKNVIL 235

  Fly   220 YSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTV 284
            |.||.:||.||.:.|.|:|:..||..||:|||:.||||:.|.||||:|||||:||.:::||:|||
Zfish   236 YGCCSDPYPDITYTLHLKRRASFYIFNLLIPCMMISFLAPLGFYLPADSGEKVSLGVTVLLALTV 300

  Fly   285 FFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQIL 349
            |.||:||.:|| |..|||:|||.:.||.::|.|..:||.::|::...|....:..|.:|..:..|
Zfish   301 FQLLVAESMPP-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEAQPVPSWARRFILNYL 364

  Fly   350 PKLL--------CIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASH 406
            .:..        |:      ....|||                     :|: ..:..|.......
Zfish   365 ARFCFVYDMGQSCV------SVHTDQP---------------------AKK-GNNCTINGQARGE 401

  Fly   407 RFDLAAAGGISAHC---FAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPT 468
            .|.|....|.|...   |.|...|:..|....:.......|...:|..|....|.....|....:
Zfish   402 DFALRLHEGCSQKVKDQFNEDASPTLSPQQRKEHQSGWRIGTFVEIEHGESAGATGETGASRKES 466

  Fly   469 FEKPYAREM----------EKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIAC 523
            .:|   ||:          :..:....:||...:.:...:....:|:.||.|:||.|:|||.|..
Zfish   467 VKK---REILVESQCLCHQQALLRNVEYIANFYQEQKATQRRNAEWRKVAKVMDRFFMWIFFIMV 528

  Fly   524 VVGTALIILQA 534
            .:.:.|||.:|
Zfish   529 FLMSLLIIGKA 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	90/216 (42%)
		LIC	27..530	CDD:455710	177/523 (34%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
LOC101882637	XP_021324910.1	LGIC_ECD	50..256	CDD:475126	90/214 (42%)
		LGIC_TM_cation	257..>344	CDD:349853	49/87 (56%)
		TM1 helix	257..281	CDD:349853	14/23 (61%)
		Neur_chan_memb	263..535	CDD:460753	85/303 (28%)
		TM2 helix	289..310	CDD:349853	12/20 (60%)
		TM3 helix	320..342	CDD:349853	8/21 (38%)