Protein Alignment nAChRalpha1 and LOC100537401

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_021333008.2
• Gene: LOC100537401 / 100537401
• -ID: -
• Length: 552
• Species: Danio rerio
• Alignment Length: 548
• Identity: 224/548 - (40%)
• Similarity: 318/548 - (58%)
• Gaps: 81/548 - (14%)

  Fly    26 KRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKW-- 88
            :||.:.|||.|::|.|||.:.||.:.|..||.::|||||:.|||:|||||||:|||.||:|:|
Zfish    25 ERLLNSLLSAYSKLTRPVHSVSDVVHVHFGLSIAQLIDVDEKNQMMTTNVWVKQEWLDYRLRWTP 89

  Fly    89 NPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDV 153
            .|:|.|.|.::.:|::.||.|||||||||||::.||.:|||.|.|.|:|.|.|||||||.|.|||
Zfish    90 GPEDNGNVSSMRIPAQFIWKPDIVLYNNADGDFTVTHLTKAHLLHDGRVTWIPPAIYKSSCSIDV 154

  Fly   154 EYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEK 218
            .:.|||:|.|.:||||||||...:||..:   |||      :|..||:.|.||.|....|..|.|
Zfish   155 TFLPFDQQNCTIKFGSWTYDRSKIDLIRI---ADS------VDQLDYWESGEWLITSAVATYNVK 210

  Fly   219 FYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLT 283
            .|.||.|.|.||.::..:||..||||:||||||:.|..|:|||||||||.||::::|||:|||||
Zfish   211 KYECCSEEYADITYSFIIRRLPLFYTINLIIPCLLILCLTVLVFYLPSDCGEEVTMCISVLLSLT 275

  Fly   284 VFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQI 348
            ||.||:.||||||||.:||:.:||||.|:.:.|.:::|:.||||:.|||.||.|..||:|.|:.:
Zfish   276 VFLLLITEIIPPTSLVIPLIAEYLLFIMIFIILFIIITVFVLNVHHRSPDTHSMPQWVRRFFLDV 340

  Fly   349 LPKLLCIERPK---------------------------KEEPEEDQPPEVLT-----DVYHLPPD 381
            :|:.:.|:||:                           :|..||....:|.:     |::.:...
Zfish   341 MPRFIFIQRPQIWQKDAKGVCDDAQKSNKRCVDSNWKNREIKEESIRMKVYSSCLNADMHSIKSP 405

  Fly   382 VDKFVNYDSKRFS-------------GDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLP 433
            ...:.|....:..             |:..:....:|.||...:....|.|
Zfish   406 SQAYNNSTCPKMKLHKGRSQSVQVNCGERDVNLCNSSTRFRSRSMQYCSLH-------------- 456

  Fly   434 GADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFE 498
              :.:..:.:..|.|.....|..        ::.|.|.| :......|||.::||::::.:....
Zfish   457 --EHEQQTSAVFNADKFSNICKV--------MTSTGENP-SHATRLAIEGVQYIAEYLRAQHADL 510

  Fly   499 SVEEDWKYVAMVLDRMFLWIFAIACVVG 526
            ||:|:|||||||:||:|||:|.:.|::|
Zfish   511 SVKEEWKYVAMVIDRLFLWMFVLVCILG 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	113/217 (52%)
		LIC	27..530	CDD:455710	224/547 (41%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
LOC100537401	XP_021333008.2	None