Protein Alignment nAChRalpha1 and chrng

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001241879.1
• Gene: chrng / 100536659
• ZFINID: ZDB-GENE-030131-3805
• Length: 540
• Species: Danio rerio
• Alignment Length: 560
• Identity: 189/560 - (33%)
• Similarity: 295/560 - (52%)
• Gaps: 84/560 - (15%)

  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            ::|.|...:|.|.|.:.. |:.||:..||:.||||.::.|.:.||:.:.|:.||.:|.|.:.:||
Zfish    12 LWILLFRFSGALCNLEGS-LHRDLMVGYNKNIRPVESHEDIIDVKIKMTLTNLISLNEKEETLTT 75

  Fly    74 NVWVEQEWNDYKLKW----NPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHT 134
            .||:|.:|.||:|:|    ..:.|..:..:.:||:.||||||.|.||.||.:||.:....::...
Zfish    76 CVWIEMQWRDYRLRWANRTGFEVYENITRMRLPSKTIWLPDIGLENNVDGRFEVALYANTLIDPD 140

  Fly   135 GKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE---VGID 196
            |.|.|.|||||:|.|.|.|.|||||.|.|.|.|.|.||:...:.|    ..:|.||:.   :.||
Zfish   141 GSVYWLPPAIYRSSCAIKVNYFPFDWQNCSMVFRSQTYNSNEITL----MLSDEDNVTMEWIEID 201

  Fly   197 LQDYYISVEWDIMRVPA--VRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
            .:.:..:.||.|...||  |.|:: |...|..:.:|:|.|.::||.|||.:|:|:|||..|.|.:
Zfish   202 PEAFTENGEWMIKHRPAKKVINKR-YRPDELEHQEIIFFLIIQRKPLFYVINIIVPCVLFSSLGL 265

  Fly   260 LVFYLPSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIA 323
            ||::||:.: |:|.::.|.|||..|||..|:|:.:|.||..|||:||||:|.|.:.|::|:..:.
Zfish   266 LVYFLPAKAGGQKCTMTICILLGQTVFLFLIAKKVPETSQAVPLIGKYLMFVMSVTTITVMNCVV 330

  Fly   324 VLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNY 388
            ||||:.|:|.||.|:..::::.:.|||::|.:.. ::..||:::.
Zfish   331 VLNVSLRTPNTHPMSNTIRKVLLNILPRVLRMTM-QRWTPEQEEG-------------------- 374

  Fly   389 DSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFS------------ 441
            |.|.|:...|.| |....|..|........:.|.          ....:.:||
Zfish   375 DFKMFALGNGTP-LRRRRRSSLGLIAKADEYMFR----------TARSELMFSRLKERKGLLKNT 428

  Fly   442 ----PSGLNGDISPGC-CPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVE 501
                .:||.|:.:... |..|||      ||        |:::.:...:.||:..|:::.|:|..
Zfish   429 LEKIQNGLGGNTAQDLECSLAAA------SP--------EVQQCVSSCKHIAESTKHQNDFQSKN 479

  Fly   502 EDWKYVAMVLDRMFLWIFAIACVVGTALIIL-----QAPS 536
            |:|..||.|:|||..::.|:..::||..|.|     ||||
Zfish   480 EEWFLVARVIDRMCFFVMALLFILGTIGIFLTGHFNQAPS 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	86/223 (39%)
		LIC	27..530	CDD:273305	178/529 (34%)
		Neur_chan_memb	247..530	CDD:280999	87/300 (29%)
chrng	NP_001241879.1	LIC	21..511	CDD:273305	182/541 (34%)
		Neur_chan_LBD	27..246	CDD:280998	86/224 (38%)
		Neur_chan_memb	253..509	CDD:280999	87/301 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810