Protein Alignment nAChRalpha1 and chrna6

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_031759256.1
• Gene: chrna6 / 100495287
• XenbaseID: XB-GENE-6033398
• Length: 488
• Species: Xenopus tropicalis
• Alignment Length: 523
• Identity: 205/523 - (39%)
• Similarity: 316/523 - (60%)
• Gaps: 71/523 - (13%)

  Fly    18 GGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWN 82
            |.|.....::|:..||:.||:.||||.|.||.:.|...:.::||::|:..|||:.||:|:...||
 Frog    24 GSLQCETEEKLFQKLLARYNQHIRPVENVSDPVMVHFEVAITQLVNVDEVNQILETNLWLRHIWN 88

  Fly    83 DYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKS 147
            ||||:|||::|.|::.:.:|::.||.|||||||||.|:::|...:||::.:.|.:.|.||||:||
 Frog    89 DYKLQWNPEEYDGIEFMRIPADKIWKPDIVLYNNAVGDFQVEGKSKALVKYNGLITWSPPAIFKS 153

  Fly   148 FCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVP 212
            .|.:|:.:||||.|.|.||||||:||...:||..:...         :|::|::.:.||:|:...
 Frog   154 SCPMDITFFPFDHQNCSMKFGSWSYDKAKIDLAIIGSK---------VDMKDFWENSEWEIVDAS 209

  Fly   213 AVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCIS 277
            ..:::..|:||||.|.||.::..:||..:|||:|||:||:.:|||:|||||||||.|||::||||
 Frog   210 GFKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIMPCLFLSFLTVLVFYLPSDCGEKVTLCIS 274

  Fly   278 ILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQ 342
            :|||||||.|::.|.||.|||.:||:|:||||||:.||||:|||:.|||:::|:|.||:|..||:
 Frog   275 VLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHKMPMWVK 339

  Fly   343 RLFIQILPKLLCIER--PKKEEPEEDQPPEVLTD-----VYHLPPDVDKFVNYDSKRFSGDYGIP 400
            .:|::.|||||.:::  .||..|...|..:...:     |.....:|::|  .|...:
 Frog   340 DVFLKRLPKLLMMKKTVEKKNRPYSKQNRKKSCEKSSELVDSESAEVEQF--EDESCY------- 395

  Fly   401 ALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADL 465
                              ||.......|.:......|.       ||.:..  |
 Frog   396 ------------------HCMRSKEQSSRVRRRQQRDS-------NGAVQE--C----------- 422

  Fly   466 SPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALI 530
                    :.|:.:.::..:|:|.::::.::.:..|:||||||||:||:|||:|.:.|||||..:
 Frog   423 --------SSELTEVVDSIQFMAGNIRDHNERKEEEDDWKYVAMVIDRVFLWVFILLCVVGTTGL 479

  Fly   531 ILQ 533
            .||
 Frog   480 FLQ 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	90/217 (41%)
		LIC	27..530	CDD:455710	201/509 (39%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
chrna6	XP_031759256.1	LIC	29..481	CDD:455710	201/515 (39%)
		LGIC_ECD	31..237	CDD:475126	90/214 (42%)