Protein Alignment nAChRalpha1 and chrna9

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_012811629.2
• Gene: chrna9 / 100493319
• XenbaseID: XB-GENE-983401
• Length: 494
• Species: Xenopus tropicalis
• Alignment Length: 559
• Identity: 190/559 - (33%)
• Similarity: 281/559 - (50%)
• Gaps: 98/559 - (17%)

  Fly     1 MGSVLFAAVFIALHF-----ATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQ 60
            :|.:|| .||:.|..     |.|..    |:.|:.||..:|:..:|||.:....|.|.:.:.|||
 Frog     8 VGQLLF-HVFVLLDLKGVESAKGKY----AQMLFRDLFEDYSNALRPVEDTDKALNVSLQITLSQ 67

  Fly    61 LIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTI 125
            :.||:.:|||:|..:|:...|.|..|||:.|:|.|:|::.:||..:|.|||||||.||..:...:
 Frog    68 IKDVDERNQILTAYLWIRLSWYDAYLKWDRDEYDGLDSIRIPSNMVWRPDIVLYNKADDEFSEPV 132

  Fly   126 MTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDN 190
            .|..:|.:.||:.|..|||.||.|.:||.|||||.|.|.:.||||||:|..||:.:   |.||.
 Frog   133 NTNVVLRYDGKITWDSPAITKSSCVVDVSYFPFDNQQCNLTFGSWTYNGNQVDIIN---TMDSG- 193

  Fly   191 IEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGIS 255
                 ||.|:..:|||::..:|||:|...|.||.|||.||.|.|.|:|::.||..||:||||.||
 Frog   194 -----DLSDFVENVEWEMQGMPAVKNVITYGCCSEPYPDITFTLILKRRSSFYIFNLLIPCVMIS 253

  Fly   256 FLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            ||:.|.||||:|||||:||.:::||:||||.|::||.:|| |.:|||:|||.:.||.::|.|..:
 Frog   254 FLAPLGFYLPADSGEKVSLGVTVLLALTVFQLMVAESMPP-SESVPLIGKYYIATMTMITASTAL 317

  Fly   321 TIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCI--------------------ERPKKEEPEE 365
            ||.::|::...|....:..|.:.:.:..:.|:..:                    ..|..|:.|:
 Frog   318 TIIIMNIHLCGPEAKPIPRWARIVILDYMSKIFFVYDVGENCTSPQSDSDTKSNGSVPSYEDYEK 382

  Fly   366 DQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSL 430
            :|.|                  |.|      .|.|         |:.:|..|.
 Frog   383 EQEP------------------YSS------LGCP---------LSGSGNFSC------------ 402

  Fly   431 PLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKD 495
                   |:.:...|||.:      ....|...::|.|....:............:|....:.:.
 Frog   403 -------DIDTNKKLNGHL------GGHYALQKEISETHCCAHCNRYRVLTNNIEYITNWYREQK 454

  Fly   496 KFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQA 534
            ...:...:||.||.|:||.|:|:|.......:.|||.||
 Frog   455 AISAKGIEWKKVAKVMDRFFMWVFFSMVFFMSILIIAQA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	95/214 (44%)
		LIC	27..530	CDD:273305	176/522 (34%)
		Neur_chan_memb	247..530	CDD:280999	79/302 (26%)
chrna9	XP_012811629.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910