Protein Alignment nAChRalpha1 and gabrr3

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_017947352.2
• Gene: gabrr3 / 100487991
• XenbaseID: XB-GENE-6039478
• Length: 481
• Species: Xenopus tropicalis
• Alignment Length: 299
• Identity: 61/299 - (20%)
• Similarity: 128/299 - (42%)
• Gaps: 21/299 - (7%)

  Fly    33 LSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVD 97
            :.:::..:|| |.....:.|.:.:::..:..::..:...|..:::...|.|.:|.:...:...:.
 Frog    83 IDDHDFAMRP-GFGGSAIPVGIDVQIESIDSISEVDMDFTMTLYLRHYWKDERLSFQSTNNRSMT 146

  Fly    98 TLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAIL--HHTGKVVWKPPAIYKSFCEIDVEYFPFDE 160
            ......:.||:||:...::.......|.|...:|  :..|.|::.......:.|.:|...||.|.
 Frog   147 FDGRLIKKIWVPDVFFVHSKRSFIHDTTMENIMLRVYPDGNVLFSLRITVTAMCFMDFSRFPLDT 211

  Fly   161 QTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEE 225
            |.|.::..|:.|:...:.| :.|:..:|...:..|.|..::|.      ...|.....|||....
 Frog   212 QNCSLELESYAYNEEDLML-YWKRGNESLKTDEHIALSQFFIE------EFSASNGLAFYSSTGW 269

  Fly   226 PYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYL-----PSDSGEKISLCISILLSLTVF 285
             |..:..|..|||...|:.:....|.:.:..||.:.|::     |:    ::||.|:.:|:::..
 Frog   270 -YNRLFINFILRRHIFFFLLQSYFPAMLMVMLSWVSFWIDRRAVPA----RVSLGITTVLTMSTI 329

  Fly   286 FLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324
            ...::..:|..|. :..:..||..:.:.|.|||:...||
 Frog   330 ITGVSASMPQVSY-IKAVDVYLWISFLFVFLSVIEYAAV 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	41/210 (20%)
		LIC	27..530	CDD:455710	61/299 (20%)
		Cys-loop	149..163	CDD:349832	6/13 (46%)
gabrr3	XP_017947352.2	LIC	77..480	CDD:455710	61/299 (20%)
		LGIC_ECD	98..283	CDD:475126	38/192 (20%)