Protein Alignment nAChRalpha1 and LOC100487782

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_031759268.1
• Gene: LOC100487782 / 100487782
• XenbaseID: XB-GENE-29078911
• Length: 512
• Species: Xenopus tropicalis
• Alignment Length: 541
• Identity: 200/541 - (36%)
• Similarity: 302/541 - (55%)
• Gaps: 69/541 - (12%)

  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            :|:.|....|.......::||.:||.|||||.|||.|:|..|.|::.|.|.|:|||:.|||::.|
 Frog    18 IFVILTLPGGSHQGQYQRKLYRELLRNYNRLERPVVNDSQPLLVELQLTLLQIIDVDEKNQVLIT 82

  Fly    74 NVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV 138
            |.|::..|||:.|.|:..:|.||.||..|::|||:|||:|||:||..::.|..|..:::.||...
 Frog    83 NAWLQITWNDFYLTWDQAEYPGVQTLRFPADHIWVPDILLYNSADERFDATFHTNVLVNSTGACQ 147

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYIS 203
            :.||.|.||.|.|||.:||||.|.|.:||||||::|:::||:.::           .|:..|..:
 Frog   148 YIPPGILKSTCYIDVRWFPFDVQKCKLKFGSWTHNGWLLDLQMME-----------ADISSYIPN 201

  Fly   204 VEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDS 268
            .|||::.||..|||.:|.||:|||.|:.:.:|:||:||:|.:||:||||.||.|::|||.||:||
 Frog   202 GEWDLVGVPGKRNELYYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPADS 266

  Fly   269 GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPV 333
            ||||||.|::|||||||.||:|||:|.||.:|||:.:|....|::|.||||||:.||..:...|.
 Frog   267 GEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASIMVIVGLSVVVTVLVLQFHHHDPQ 331

  Fly   334 THRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYG 398
            ..:|...|:.:.:.     .|....:..:|.|::.|.....:|         .|:.|...|.:..
 Frog   332 AGKMPKMVRVILLN-----WCAWFLRMRKPGENKRPIPCKYIY---------PNHHSSISSIEMN 382

  Fly   399 IPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPA---AAAA 460
            |   ...|:    :..|...:|                       |.:...|| |||.   :...
 Frog   383 I---APGHQ----STNGNIVYC-----------------------GYHTLESP-CCPPNSDSGVM 416

  Fly   461 AAADLSPTFE----------KPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMF 515
            .|....|:.|          |....|:.|.:|..::||:..:.:|..|.:..:||:.|.|:||:.
 Frog   417 CARVNCPSLEDSDLIQKKSLKESMPEIVKILEEVQYIARRFREQDAGEEICSEWKFAAAVIDRLC 481

  Fly   516 LWIFAIACVVGTALIILQAPS 536
            |..|::..::.|..|::.||:
 Frog   482 LVAFSLFAIIATFTILMSAPN 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	99/217 (46%)
		LIC	27..530	CDD:455710	194/515 (38%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
LOC100487782	XP_031759268.1	LIC	16..500	CDD:455710	198/537 (37%)