DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and chrnb3

DIOPT Version :9

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:XP_002942943.1 Gene:chrnb3 / 100379831 XenbaseID:XB-GENE-5793509 Length:460 Species:Xenopus tropicalis


Alignment Length:545 Identity:226/545 - (41%)
Similarity:313/545 - (57%) Gaps:102/545 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SVLFAAVFIALHFATGGLA--NPDAK---RLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLI 62
            |..|.::.|.::|...|.|  :|.|:   .|...|.:.|.:.:|||.|.:..:.|..||::|||:
 Frog     4 SARFLSLSITVYFINSGFAKFHPLAEIEDALLRKLFAGYQKWVRPVLNPNSTIKVNFGLKISQLV 68

  Fly    63 DVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMT 127
            ||:.|.|:||||||:.|||.|.||:|||.||||:..:.||||.:|||||||:.||||.:|.::||
 Frog    69 DVDEKKQLMTTNVWLRQEWMDMKLRWNPKDYGGITYIRVPSESLWLPDIVLFENADGRFEGSLMT 133

  Fly   128 KAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE 192
            |||:.:.|.|.|.|||.|||.|.:||.:||||.|.|.||||||||||.||||..|.:        
 Frog   134 KAIIKYDGTVTWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLILLDE-------- 190

  Fly   193 VGIDLQDYYISVEWDIMR---VPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGI 254
             .:|.:|::.:.||||:.   :..:|.:..||     |..|.::..|||..||||:.|||||:|:
 Frog   191 -NVDRKDFFDNGEWDILNATGLKGMRKDGLYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGL 249

  Fly   255 SFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVV 319
            |||:|||||||||.|||:||..|:|:|||||.|::.||||.:|..:||:|:||||.|:.||||::
 Frog   250 SFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSII 314

  Fly   320 VTIAVLNVNFRSPVT-HRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVD 383
            ||:.|:||:.||..| |.|||||:|||::.||||||::                       ..||
 Frog   315 VTVFVINVHHRSSATYHPMAPWVKRLFLEKLPKLLCMK-----------------------GHVD 356

  Fly   384 KFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGD 448
            :|..:||:.                |:::|..                         .|||...:
 Frog   357 RFSFFDSES----------------DVSSAKS-------------------------KPSGKRKN 380

  Fly   449 ISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDR 513
            |.           |:|    .||.....:||..:..::|:.|||.:.....|.:|||:||.||||
 Frog   381 IH-----------ASD----GEKVLIAFLEKAADSIKYISTHVKKEHFIRQVVQDWKFVAQVLDR 430

  Fly   514 MFLWIFAIACVVGTALIILQAPSLY 538
            :|||:|....:.|:.||...|..::
 Frog   431 IFLWLFLSVSITGSVLIFTPALQMW 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 Neur_chan_LBD 25..240 CDD:280998 105/220 (48%)
LIC 27..530 CDD:273305 215/506 (42%)
Neur_chan_memb 247..530 CDD:280999 107/283 (38%)
chrnb3XP_002942943.1 LIC 2..451 CDD:273305 225/539 (42%)
LGIC_ECD_nAChR_B3 56..234 CDD:349827 96/191 (50%)
Cys-loop 155..169 CDD:349827 8/13 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 252 1.000 Domainoid score I2037
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm9533
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.010

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