Protein Alignment nAChRalpha1 and LOC100334841

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_009294780.1
• Gene: LOC100334841 / 100334841
• -ID: -
• Length: 467
• Species: Danio rerio
• Alignment Length: 550
• Identity: 125/550 - (22%)
• Similarity: 220/550 - (40%)
• Gaps: 157/550 - (28%)

  Fly    19 GLANPDAKRLYDDLLSNYNR-LIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWN 82
            |.:.|.    |:.|....|| ..||..|.:......:...|..::.||.|.||:||.:|:...|.
Zfish    30 GQSGPS----YESLQEVINRKSFRPSINLNTPTITNISFTLYAILGVNEKAQILTTFLWLRLYWF 90

  Fly    83 DYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKA----ILHHTGKVVWKPPA 143
            ...|.|.|:....:..:.:|...:|.|||::|...|.:     :::|    .::|||.:.:....
Zfish    91 HEFLIWEPELCDDITKISLPVADLWTPDIIVYEFVDDD-----VSQACPYVYVNHTGHIRYDRML 150

  Fly   144 IYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDL----------------RHLKQT------- 185
            ...|.|.:.:..||||.|.|...|||:.:.  :.|:                |:|:.:
Zfish   151 RLVSACNLQIFSFPFDIQNCTFTFGSYMHT--IKDVRVSPALSFKEMTENSKRYLQASGEWELVV 213

  Fly   186 --ADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLI 248
              .|.|.:..|||        ||||                     |.|.:.::|:.:.|.||||
Zfish   214 ILGDVDILNFGID--------EWDI---------------------ITFWVVIKRRPILYVVNLI 249

  Fly   249 IPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMML 313
            ||...:..:.:|.||||..|.::.|..::::|..|||.|::.:::|.|:...||:|.|....:.|
Zfish   250 IPSAFLMIIDILSFYLPPHSVDRSSFKMTLILGYTVFLLIMNDLLPSTANGTPLIGIYFSVCLAL 314

  Fly   314 VTLSVVVTIAVLNVNFRSPVTHRMAP-WVQRLFIQILPKLLCIERPKKEEP----EEDQPPEVLT 373
            :.||::.|:.:..|...:.:.:|..| |||.|.|:.:.:|:|...|  |:|    ||.|
Zfish   315 MVLSLLETVLITCVLHHNSMKYRPVPHWVQVLVIRFIARLICYSFP--EDPLAKFEEKQ------ 371

  Fly   374 DVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDD 438
                   |.:.:|...::..||.
Zfish   372 -------DTNPWVAQSTESTSGQ------------------------------------------ 387

  Fly   439 LFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTI-EGSRFIAQHVKNKDKFESVEE 502
                               ..|..|..:.|.:.|..|::.:.: |.|.:::  :..|:  :.::.
Zfish   388 -------------------QIATNASGTMTLDVPELRQISQDLKEMSTYLS--ILRKE--DHLQN 429

  Fly   503 DWKYVAMVLDRMFLWIFAIACVVGTALIIL 532
            .|.:|..:||.:...|: :..:.|.||:|:
Zfish   430 QWCHVGYILDFLLFRIY-LLIITGYALVII 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	57/247 (23%)
		LIC	27..530	CDD:455710	121/538 (22%)
		Cys-loop	149..163	CDD:349832	6/13 (46%)
LOC100334841	XP_009294780.1	LIC	8..465	CDD:455710	125/549 (23%)
		LGIC_ECD	29..240	CDD:475126	58/249 (23%)