Protein Alignment nAChRalpha1 and chrna1

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_002934647.1
• Gene: chrna1 / 100145177
• XenbaseID: XB-GENE-977139
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 523
• Identity: 206/523 - (39%)
• Similarity: 305/523 - (58%)
• Gaps: 89/523 - (17%)

  Fly     9 VFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTT 73
            :|||   ||...::.|..||.:||..:||:::|||....|::.|.:||:|.|||:|:..|||:||
 Frog    11 LFIA---ATLVFSSEDESRLINDLFKSYNKVVRPVKAFKDKVVVTLGLQLIQLINVDEVNQIVTT 72

  Fly    74 NVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVV 138
            ||.::|:|.|..|||||:||||:..:.:.|..||.|||||||||||::.:...||.:|.:|||::
 Frog    73 NVRLKQQWEDVHLKWNPEDYGGIKKVRISSGDIWRPDIVLYNNADGDFAIVQETKVLLDYTGKII 137

  Fly   139 WKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYIS 203
            |.||||:||:||:.|.|||||.|.|.||.|:|||||.:|.:     ..:||.    .||.::..|
 Frog   138 WTPPAIFKSYCEMIVTYFPFDLQNCSMKLGTWTYDGSLVVI-----NPESDR----PDLSNFMES 193

  Fly   204 VEWDIMRVPAVRNEKFYSCC-EEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSD 267
            .||.:......::..:|.|| |.|||||.::..|:|..|::.||::|||:..|||:.||||||:|
 Frog   194 GEWYMKDYRGWKHWVYYDCCPETPYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTGLVFYLPTD 258

  Fly   268 SGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSP 332
            |||||:|.:|:||||.||.|::.|:||.||..|||:|||:||||:.|..|:|:|:.|:|.:.|||
 Frog   259 SGEKITLSVSVLLSLVVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVITSIVITVIVINTHHRSP 323

  Fly   333 VTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDY 397
            .||.|..|::::||:.:|:::.....|:  |.:||..:                    |.|:.|.
 Frog   324 STHIMPQWLKKIFIETIPRVMFFSTMKR--PAQDQQKK--------------------KIFTEDI 366

  Fly   398 GIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAA 462
            .|                                           |.::|.:.|        ||.
 Frog   367 DI-------------------------------------------SDISGKLGP--------AAV 380

  Fly   463 ADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGT 527
            ...||..:.|   :::..|||:::||:.:|:..:.....|:||:||||||.:.|.:|.|.|::||
 Frog   381 KYQSPILKNP---DVKSAIEGAKYIAETMKSDQESNKASEEWKFVAMVLDHLLLAVFMIVCIIGT 442

  Fly   528 ALI 530
            ..|
 Frog   443 LAI 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	101/215 (47%)
		LIC	27..530	CDD:273305	199/503 (40%)
		Neur_chan_memb	247..530	CDD:280999	95/282 (34%)
chrna1	XP_002934647.1	LIC	21..447	CDD:273305	201/510 (39%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	102/217 (47%)
		Cys-loop	148..162	CDD:349815	9/13 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110