Protein Alignment nAChRalpha1 and chrnb1l

DIOPT Version :9

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001233249.1
• Gene: chrnb1l / 100005295
• ZFINID: ZDB-GENE-060811-1
• Length: 486
• Species: Danio rerio
• Alignment Length: 548
• Identity: 193/548 - (35%)
• Similarity: 298/548 - (54%)
• Gaps: 78/548 - (14%)

  Fly     9 VFIALHFATGG--LANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIM 71
            |::.:::...|  .|:...:||.:||..:||..:||....::|:.|::|:.|.|||.:|.||..|
Zfish     2 VWLNINYDINGSRKASEAERRLLEDLFQDYNLKVRPARTWNERVMVRVGMTLVQLISLNQKNGEM 66

  Fly    72 TTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGK 136
            ||||::..||.||:|.|||:||..:|.:.:|...:|.|||.|.||.||.::|.:....::...|.
Zfish    67 TTNVFMNMEWTDYRLSWNPEDYDKIDVVRIPPVKVWRPDIYLINNNDGQFDVALYVNVLVRSDGT 131

  Fly   137 VVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYY 201
            |.|.|||||:|.|.|:|.|||||.|.|.|.|.|:|||...|||::......::..|:.||...:.
Zfish   132 VSWLPPAIYRSSCSIEVAYFPFDWQNCSMVFRSYTYDSSEVDLQYGLDEDGNELHEIVIDENAFT 196

  Fly   202 ISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS 266
            .:.||.|...|:.:|.:     ::.|.||.|.|.:.||.|||.:|:|:||:..|.|::.|||||.
Zfish   197 ENGEWQICHKPSRKNVQ-----DDLYEDITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPP 256

  Fly   267 DSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRS 331
            .:|||::|.||:|::||||.||||:.:|.|||.:|::..|::|||:|||.||::::.|||::.|:
Zfish   257 GAGEKMTLSISVLIALTVFMLLLADKVPETSLAIPIIVNYVMFTMILVTFSVILSVVVLNLHHRT 321

  Fly   332 PVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGD 396
            |.||.|..||:::||.:||:.|.:.||..|||.|::|.|          :|......:|.|..|:
Zfish   322 PSTHHMPGWVRKVFINLLPRYLGVLRPTPEEPVEEEPKE----------NVPMGCLGNSLRPGGE 376

  Fly   397 YGI----PAL----PASHR---FDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS 450
            |.|    |.|    ..||.   ..|........:|...||
Zfish   377 YFIRKINPELVMPWRGSHNESTVKLQRFSNSDNYCLILPP------------------------- 416

  Fly   451 PGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMF 515
                                     .::..|....::::.:|.:|..:::.:||:|:|:||||:|
Zfish   417 -------------------------NLKSAIAAITYMSEQLKKQDVDDTMTDDWQYIAVVLDRLF 456

  Fly   516 LWIFAIACVVGTALIILQAPSLYDQSQP 543
            ||:|.:...:||..:.|.|...|...||
Zfish   457 LWLFVVITTLGTLTMFLDASFNYTPDQP 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	87/214 (41%)
		LIC	27..530	CDD:273305	185/513 (36%)
		Neur_chan_memb	247..530	CDD:280999	93/293 (32%)
chrnb1l	NP_001233249.1	LIC	11..473	CDD:273305	187/526 (36%)
		Neur_chan_LBD	20..230	CDD:280998	87/214 (41%)
		Neur_chan_memb	237..472	CDD:280999	93/294 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910