DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha1 and chrnb5a

DIOPT Version :9

Sequence 1:	NP_001262916.1	Gene:	nAChRalpha1 / 42918	FlyBaseID:	FBgn0000036	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_009289434.1	Gene:	chrnb5a / 100003503	ZFINID:	ZDB-GENE-090312-169	Length:	494	Species:	Danio rerio

Alignment Length:	533	Identity:	234/533 - (43%)
Similarity:	316/533 - (59%)	Gaps:	78/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LANPDAKRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWN 82
            ||....:||.|.||  ..||:||||..|.|.::|:.:.:.|:|||.||.:.||||||||:.||||
Zfish    24 LAADAEERLVDFLLGPERYNKLIRPAVNKSQQVTIGIKVSLAQLISVNEREQIMTTNVWLTQEWN 88

  Fly    83 DYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKS 147
            ||:|.|:|::|.|:..|.:||.|||||||||||||||.|||:....|::.:||.:.|.|||||||
Zfish    89 DYRLVWDPNEYEGIKKLRIPSRHIWLPDIVLYNNADGVYEVSFYCNAVVSNTGDIFWLPPAIYKS 153

  Fly   148 FCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVP 212
            .|.|:|..||||:|.|.:||.|||||...:||......|..|         ||..|.||||:.:|
Zfish   154 ACAIEVRNFPFDQQNCTLKFRSWTYDRTELDLYLTSDFASRD---------DYTPSGEWDIVSLP 209

  Fly   213 AVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCIS 277
            ..|||   ...:..|||:.::..::||.||||:|||||||.|:.|::||||||||.|||::||||
Zfish   210 GRRNE---DLSDPTYLDVTYDFVIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCIS 271

  Fly   278 ILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQ 342
            :||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.||||:.|||.||||..||:
Zfish   272 VLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHRMPEWVK 336

  Fly   343 RLFIQILPKLLCIERPKKEEPEE-----DQPPEVLTDVYHLPPDVDK-FVNYDSKRFSGDYGIPA 401
            |:|:..||..|.:.||.:....|     .|.....:|...|..|.|. |::.|..|..|.:.:
Zfish   337 RVFLHKLPFFLLMRRPGRSNVRERFRRKHQRKSFSSDTKGLRLDGDSYFLSDDPGRVCGAWRV-- 399

  Fly   402 LPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLS 466
                                                         ||:..|          ::..
Zfish   400 ---------------------------------------------GDLPEG----------SEFR 409

  Fly   467 PTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALII 531
            ...:..:..::::.|||.||||:|:|.:|..|.:.|||||||||:||:|||||.:.|||||..:.
Zfish   410 QRVKVRHDPDVDEAIEGVRFIAEHMKIEDDDEGIIEDWKYVAMVIDRLFLWIFILVCVVGTLGLF 474

  Fly   532 LQAPSLYDQSQPI 544
            :| |.....:.|:
Zfish   475 VQ-PLFQSYNTPV 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	106/216 (49%)
		LIC	27..530	CDD:273305	229/510 (45%)
		Neur_chan_memb	247..530	CDD:280999	117/288 (41%)
chrnb5a	XP_009289434.1	Neur_chan_LBD	20..474	CDD:332142	231/518 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2314
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24622
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920