DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18528 and MSS1

DIOPT Version :9

Sequence 1:	NP_651251.3	Gene:	CG18528 / 42906	FlyBaseID:	FBgn0039189	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_013736.1	Gene:	MSS1 / 855037	SGDID:	S000004625	Length:	526	Species:	Saccharomyces cerevisiae

Alignment Length:	523	Identity:	179/523 - (34%)
Similarity:	282/523 - (53%)	Gaps:	45/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLRNASQSFLGSFRRFASSGCTIYSLSS-GHVKCGVSVIRVSGPQTKKALRAIVANKEYEPKARQ 66
            |:|.:.:.:.|..:.:.....|||:||: .:....:::||:||...|.....:| :....|..|:
Yeast    17 LVRRSLKRYSGLAKPYTFQQPTIYALSTPANQTSAIAIIRISGTHAKYIYNRLV-DSSTVPPIRK 80

  Fly    67 AYLKSFYHPA-----------SKEMIDRGLLLWFPGPASFTGEDSCEFQVHGSLAVIAAMLDALG 120
            |.|::.|.|:           ||.::|..|||:|..|.||||||..|..|||..||:.::|.|:|
Yeast    81 AILRNIYSPSSCSVKPHDQKESKILLDTSLLLYFQAPYSFTGEDVLELHVHGGKAVVNSILKAIG 145

  Fly   121 KV------DGLRPAEPGEFTKRAFFGGKLDLTEVEGLADLIHAETEAQRKQALLQSTGALARLYD 179
            .:      ..:|.|.||:|::|||..||.|||::||:.|||.:|||:||:.||....|....|::
Yeast   146 SLHDRSSGKDIRFALPGDFSRRAFQNGKFDLTQLEGIKDLIDSETESQRRSALSSFNGDNKILFE 210

  Fly   180 NWRRRLIRCAAHLEAYIDFAEEEQIE----GGIILQLGKELKAVKREIREHLSDQRQGELLRDGV 240
            |||..:|...|.|.|.||||::...|    ..|...:.|.:..::.:|...:....:..:|::|:
Yeast   211 NWRETIIENMAQLTAIIDFADDNSQEIQNTDEIFHNVEKNIICLRDQIVTFMQKVEKSTILQNGI 275

  Fly   241 RTVIIGAPNVGKSSLLNLLCQRSVSIVTDQAGTTRDIIETMHNFGGYPVVFSDTAGLRRYTTDSI 305
            :.|::||||||||||:|.|....:|||:|..|||||.|:.|.|..||.|:..||||:|..::|.|
Yeast   276 KLVLLGAPNVGKSSLVNSLTNDDISIVSDIPGTTRDSIDAMINVNGYKVIICDTAGIREKSSDKI 340

  Fly   306 EQEGMQRAKNCLVQSDLILLLAEAKNIAQLTHDDAVAPFVDSYLGELDIPLDMCSGKRLQLVANK 370
            |..|:.|||...|||||.|.:.:..::::|..:|.:|.......|          .||:.:|.||
Yeast   341 EMLGIDRAKKKSVQSDLCLFIVDPTDLSKLLPEDILAHLSSKTFG----------NKRIIIVVNK 395

  Fly   371 TDTLTDEEHQQ-LDKLSN-------VLAISCHKPDKMPVFLGSLEKQLQELCGEPRAENPRITNT 427
            :|.::|:|..: |:||..       :|::||...:.:...:.:|....:.|.......:|.|.:.
Yeast   396 SDLVSDDEMTKVLNKLQTRLGSKYPILSVSCKTKEGIESLISTLTSNFESLSQSSADASPVIVSK 460

  Fly   428 RYRQQLER-CIENIDIFLRDYRPDVYPDMAIAASKLRNSVRCIERITGH-ISCEDILDVVFKDFC 490
            |..:.|:. .:..::.|.:.  .|.:.|:.:|...||.:...|.:|||. |..|:|||.||..||
Yeast   461 RVSEILKNDVLYGLEEFFKS--KDFHNDIVLATENLRYASDGIAKITGQAIGIEEILDSVFSKFC 523

  Fly   491 IGK 493
            |||
Yeast   524 IGK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18528	NP_651251.3	trmE	24..493	CDD:235392	174/500 (35%)
		TrmE_N	24..142	CDD:287381	48/135 (36%)
		trmE	237..415	CDD:206727	67/185 (36%)
MSS1	NP_013736.1	MnmE	38..526	CDD:223561	174/500 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345785
Domainoid	1	1.000	190	1.000	Domainoid score	I640
eggNOG	1	0.900	-	-		E1_COG0486
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6600
Inparanoid	1	1.050	275	1.000	Inparanoid score	I582
Isobase	1	0.950	-	0	Normalized mean entropy	S1676
OMA	1	1.010	-	-		QHG62483
OrthoFinder	1	1.000	-	-		FOG0003953
OrthoInspector	1	1.000	-	-		oto99498
orthoMCL	1	0.900	-	-		OOG6_101467
Panther	1	1.100	-	-	LDO	PTHR42714
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R753
SonicParanoid	1	1.000	-	-		X2256
TreeFam	1	0.960	-	-
	16	15.740