DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18528 and GTPBP3

DIOPT Version :9

Sequence 1:	NP_651251.3	Gene:	CG18528 / 42906	FlyBaseID:	FBgn0039189	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_598399.2	Gene:	GTPBP3 / 84705	HGNCID:	14880	Length:	524	Species:	Homo sapiens

Alignment Length:	505	Identity:	220/505 - (43%)
Similarity:	306/505 - (60%)	Gaps:	44/505 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SGCTIYSLSSGHVKCGVSVIRVSGPQTKKALRAIVANKEYEPKARQAYLKSFYHPASKEMIDRGL 85
            ||.||::||||..:||::|||.|||.:..|||.:.|.::. |.||.|.|:....|.|.|.:||.|
Human    32 SGATIFALSSGQGRCGIAVIRTSGPASGHALRILTAPRDL-PLARHASLRLLSDPRSGEPLDRAL 95

  Fly    86 LLWFPGPASFTGEDSCEFQVHGSLAVIAAMLDALGKVDGLRPAEPGEFTKRAFFGGKLDLTEVEG 150
            :||||||.||||||..||.|||..||::.:|.|||.|.||||||.||||:|||..|||:||||||
Human    96 VLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFANGKLNLTEVEG 160

  Fly   151 LADLIHAETEAQRKQALLQSTGALARLYDNWRRRLIRCAAHLEAYIDFAEEEQIEGGIILQLGK- 214
            |||||||||||||:|||.|..|.|..|...|...|.:..||:||||||.|::.:|.|::.|.|.
Human   161 LADLIHAETEAQRRQALRQLDGELGHLCRGWAETLTKALAHVEAYIDFGEDDNLEEGVLEQGGST 225

  Fly   215 -------------------------------ELKAVKREIREHLSDQRQGELLRDGVRTVIIGAP 248
                                           |::|::..:..||.|.|:|:.||.||..|:.|.|
Human   226 WWWGRKTPHISPQRLPSLSLSACLLSPTADIEVRALQVALGAHLRDARRGQRLRSGVHVVVTGPP 290

  Fly   249 NVGKSSLLNLLCQRSVSIVTDQAGTTRDIIETMHNFGGYPVVFSDTAGLRRYTTDSIEQEGMQRA 313
            |.|||||:|||.::.||||:.:.|||||::||..:..|:||:.|||||||. ....:||||::||
Human   291 NAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLRE-GVGPVEQEGVRRA 354

  Fly   314 KNCLVQSDLILLLAEAKNIAQLTHDDAVAPFVDSYLGELDIPLDMCSGKRLQLVANKTDTLTDEE 378
            :..|.|:||||.:.:|.::|..:..:.:|..|.|...:  .|.|  |.:||.||.||:|.|:.|.
Human   355 RERLEQADLILAMLDASDLASPSSCNFLATVVASVGAQ--SPSD--SSQRLLLVLNKSDLLSPEG 415

  Fly   379 HQQLDKLSNVLAISCHKPDKMPVFLGSLEKQLQELCGEPRAENPRITNTRYRQQLERCIENIDIF 443
            ......|...|.:||...:.:...|.:|.|:|..:||:|..:.|.:|..|::..|:.|::.:..:
Human   416 PGPGPDLPPHLLLSCLTGEGLDGLLEALRKELAAVCGDPSTDPPLLTRARHQHHLQGCLDALGHY 480

  Fly   444 LRDYRPDVYPDMAIAASKLRNSVRCIERITGHISCEDILDVVFKDFCIGK 493
            .:.      .|:|:||..||.:...:.|:||....|:|||::|:|||:||
Human   481 KQS------KDLALAAEALRVARGHLTRLTGGGGTEEILDIIFQDFCVGK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18528	NP_651251.3	trmE	24..493	CDD:235392	216/500 (43%)
		TrmE_N	24..142	CDD:287381	66/117 (56%)
		trmE	237..415	CDD:206727	73/177 (41%)
GTPBP3	NP_598399.2	trmE	35..524	CDD:235392	216/500 (43%)
		TrmE_N	35..152	CDD:287381	66/117 (56%)
		trmE	279..448	CDD:206727	72/173 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157822
Domainoid	1	1.000	254	1.000	Domainoid score	I2077
eggNOG	1	0.900	-	-		E1_COG0486
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6600
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1974
Isobase	1	0.950	-	0	Normalized mean entropy	S1676
OMA	1	1.010	-	-		QHG62483
OrthoDB	1	1.010	-	-		D280742at33208
OrthoFinder	1	1.000	-	-		FOG0003953
OrthoInspector	1	1.000	-	-		oto89676
orthoMCL	1	0.900	-	-		OOG6_101467
Panther	1	1.100	-	-	LDO	PTHR42714
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R753
SonicParanoid	1	1.000	-	-		X2256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750