DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18528 and Gtpbp3

DIOPT Version :9

Sequence 1:	NP_651251.3	Gene:	CG18528 / 42906	FlyBaseID:	FBgn0039189	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_115933.2	Gene:	Gtpbp3 / 70359	MGIID:	1917609	Length:	492	Species:	Mus musculus

Alignment Length:	498	Identity:	217/498 - (43%)
Similarity:	314/498 - (63%)	Gaps:	18/498 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ALLRNASQSFLGSFRRFASS------GCTIYSLSSGHVKCGVSVIRVSGPQTKKALRAIVANKEY 60
            ||:..|:.:.|....|.::|      ..||::||||..:|.::|||.|||.:..|||::.|.:|
Mouse     7 ALVTQAAWAPLRLCARCSTSAESLVPSSTIFALSSGQGRCAIAVIRTSGPASGLALRSLTALQE- 70

  Fly    61 EPKARQAYLKSFYHPASKEMIDRGLLLWFPGPASFTGEDSCEFQVHGSLAVIAAMLDALGKVDGL 125
            .|.||:|.|:...||.|.|.:||.|:||||||.||||||..||.|||..||::.:|.|||.|.||
Mouse    71 PPPARRACLRLLRHPCSGEPLDRSLVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGL 135

  Fly   126 RPAEPGEFTKRAFFGGKLDLTEVEGLADLIHAETEAQRKQALLQSTGALARLYDNWRRRLIRCAA 190
            ||||.||||:|||..|||.|||||||||||.|||||||:|||.|..|.|::|...|.:.|.:..|
Mouse   136 RPAEAGEFTRRAFAHGKLSLTEVEGLADLIRAETEAQRRQALRQLDGELSQLCQGWAKTLTKALA 200

  Fly   191 HLEAYIDFAEEEQIEGGIILQLGKELKAVKREIREHLSDQRQGELLRDGVRTVIIGAPNVGKSSL 255
            ::||||||.|::.:|.|::.|..:|::|::..:..||.|.|:|:.|..|...|:.|.||.|||||
Mouse   201 YVEAYIDFGEDDNLEEGVLEQADREVRALEVALGSHLRDARRGQRLLSGANVVVTGPPNAGKSSL 265

  Fly   256 LNLLCQRSVSIVTDQAGTTRDIIETMHNFGGYPVVFSDTAGLRRYTTDSIEQEGMQRAKNCLVQS 320
            :|||.|:.||||:.:.|||||::||..:..|:||:.|||||||. ...::||||::||::.|.|:
Mouse   266 VNLLSQKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLRE-GVGAVEQEGVRRARHRLEQA 329

  Fly   321 DLILLLAEAKNIAQLTHDDAVAPFVDSYLGELDIPLDMCSGKRLQLVANKTDTLTDEEHQQLDKL 385
            |:||.:.:|.::|    ..:...|:|:.:..|........|:||.|:.||:|.|:.........|
Mouse   330 DIILGVLDASDLA----SSSSCSFLDTVVTPLLAQSQDSGGQRLLLLLNKSDLLSANAPACDIAL 390

  Fly   386 SNVLAISCHKPDKMPVFLGSLEKQLQELCGEPRAENPRITNTRYRQQLERCIENIDIFLRDYRPD 450
            ...|.:|||....|...|.:|:.:|..:||:|....|.:|..|::..|:.|::.:..:      .
Mouse   391 PPHLLLSCHTGAGMDSLLQALKTELAAVCGDPSTGPPLLTRVRHQYHLQGCLDALGHY------Q 449

  Fly   451 VYPDMAIAASKLRNSVRCIERITGHISCEDILDVVFKDFCIGK 493
            :..|:|:||..||.:.|.:..:||....|:|||::|:|||:||
Mouse   450 LATDLALAAEALRQARRQLNHLTGGGGTEEILDLIFQDFCVGK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18528	NP_651251.3	trmE	24..493	CDD:235392	209/468 (45%)
		TrmE_N	24..142	CDD:287381	67/117 (57%)
		trmE	237..415	CDD:206727	68/177 (38%)
Gtpbp3	NP_115933.2	trmE	35..492	CDD:235392	209/468 (45%)
		TrmE_N	35..152	CDD:287381	67/117 (57%)
		trmE	248..416	CDD:206727	67/172 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848209
Domainoid	1	1.000	250	1.000	Domainoid score	I2113
eggNOG	1	0.900	-	-		E1_COG0486
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6600
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1991
Isobase	1	0.950	-	0	Normalized mean entropy	S1676
OMA	1	1.010	-	-		QHG62483
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003953
OrthoInspector	1	1.000	-	-		oto93244
orthoMCL	1	0.900	-	-		OOG6_101467
Panther	1	1.100	-	-	LDO	PTHR42714
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R753
SonicParanoid	1	1.000	-	-		X2256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740