DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18528 and gtpbp3

DIOPT Version :9

Sequence 1:	NP_651251.3	Gene:	CG18528 / 42906	FlyBaseID:	FBgn0039189	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001018605.1	Gene:	gtpbp3 / 553807	ZFINID:	ZDB-GENE-050522-335	Length:	500	Species:	Danio rerio

Alignment Length:	499	Identity:	243/499 - (48%)
Similarity:	335/499 - (67%)	Gaps:	29/499 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SQSFLGSFRRFASSGC----TIYSLSSGHVKCGVSVIRVSGPQTKKALRAIVANKEYEPKARQAY 68
            |:|.|  .:|...||.    ||||||||..||||:|:|||||.:..|:|.:..:.   |..|.|.
Zfish    18 SRSLL--VKRLFCSGWPGDDTIYSLSSGQGKCGVAVVRVSGPASALAVRRLTRSL---PAPRTAS 77

  Fly    69 LKSFYHPASKEMIDRGLLLWFPGPASFTGEDSCEFQVHGSLAVIAAMLDALGKVDGLRPAEPGEF 133
            |:|..||.|||::||||:||||||||||||||.||.:||..|||:.:|.|||.:.||||||.|||
Zfish    78 LRSISHPQSKELLDRGLVLWFPGPASFTGEDSAEFHIHGGPAVISGVLQALGSLPGLRPAEAGEF 142

  Fly   134 TKRAFFGGKLDLTEVEGLADLIHAETEAQRKQALLQSTGALARLYDNWRRRLIRCAAHLEAYIDF 198
            |:|||:.|||||||||||:|||||||||||:|||.|..|.|.|:|.:|..:|.||.||:||:|||
Zfish   143 TRRAFYAGKLDLTEVEGLSDLIHAETEAQRRQALRQMAGDLGRIYQDWTDQLKRCLAHVEAFIDF 207

  Fly   199 AEEEQIEGGIILQLGKELKAVKREIREHLSDQRQGELLRDGVRTVIIGAPNVGKSSLLNLLCQRS 263
            :|:|.||.|::..:.:.::.::.::..||||:|:||.||.||..||.|:.|.|||||||||.||.
Zfish   208 SEDELIEDGVLNDVDRAVQQLQTDMENHLSDERRGERLRSGVHVVIAGSTNAGKSSLLNLLTQRP 272

  Fly   264 VSIVTDQAGTTRDIIETMHNFGGYPVVFSDTAGLRRYTTDSIEQEGMQRAKNCLVQSDLILLLAE 328
            .:||:..||||||::|...:.|||||:.|||||||. |:||:||||::||:..:.|:||.|::.:
Zfish   273 AAIVSPTAGTTRDVLEVPLDIGGYPVLLSDTAGLRD-TSDSVEQEGVRRARQRVEQADLSLVVVD 336

  Fly   329 AKNIAQLTHDDAVAP-FVDSYLGELDIPLDMCSGKRLQ-LVANKTDTLTDEEH-------QQLDK 384
               :.||..:....| |:..:|..:   |:..|.::.. |:.|::|.::.|:.       |:|..
Zfish   337 ---LTQLPSERRHVPVFLRGHLKNI---LERSSQQQQHILILNESDLVSAEQQRSIQTSLQELSG 395

  Fly   385 LSNVLAISCHKPDKMPVFLGSLEKQLQELCGEPRAENPRITNTRYRQQLERCIENIDIFLRDYRP 449
            ..:...:|||..|.:...|..|...|:.|||:|...:|.:|.||:|..|::.||.:..: .:||
Zfish   396 APSACFLSCHSRDGLEELLTLLHNTLKTLCGDPLIGSPTLTQTRHRTHLQKSIEALQQY-HEYR- 458

  Fly   450 DVYPDMAIAASKLRNSVRCIERITGHISCEDILDVVFKDFCIGK 493
            ||  |:|:||..||..:..:.||||.:|.|:||||:|:||||||
Zfish   459 DV--DLALAAEGLRLGLLSLGRITGRVSPEEILDVIFRDFCIGK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18528	NP_651251.3	trmE	24..493	CDD:235392	235/477 (49%)
		TrmE_N	24..142	CDD:287381	72/117 (62%)
		trmE	237..415	CDD:206727	73/186 (39%)
gtpbp3	NP_001018605.1	trmE	34..500	CDD:235392	235/479 (49%)
		TrmE_N	36..151	CDD:287381	72/117 (62%)
		MIT	<163..199	CDD:294211	22/35 (63%)
		P-loop_NTPase	<182..305	CDD:304359	62/122 (51%)
		trmE	246..422	CDD:206727	71/182 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593614
Domainoid	1	1.000	275	1.000	Domainoid score	I1722
eggNOG	1	0.900	-	-		E1_COG0486
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6600
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1703
OMA	1	1.010	-	-		QHG62483
OrthoDB	1	1.010	-	-		D280742at33208
OrthoFinder	1	1.000	-	-		FOG0003953
OrthoInspector	1	1.000	-	-		oto38938
orthoMCL	1	0.900	-	-		OOG6_101467
Panther	1	1.100	-	-	LDO	PTHR42714
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2256
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770