DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18528 and Gtpbp3

DIOPT Version :9

Sequence 1:	NP_651251.3	Gene:	CG18528 / 42906	FlyBaseID:	FBgn0039189	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001011919.1	Gene:	Gtpbp3 / 290633	RGDID:	1305367	Length:	492	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	217/480 - (45%)
Similarity:	304/480 - (63%)	Gaps:	28/480 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GCTIYSLSSGHVKCGVSVIRVSGPQTKKALRAIVANKEYEPKARQAYLKSFYHPASKEMIDRGLL 86
            |.||::||||..:|.::|||.|||.:..|||::.|.:| .|.||.|.|:...||.|.|.:||.|:
  Rat    33 GSTIFALSSGQGRCAIAVIRTSGPASGLALRSLTALRE-PPPARSACLRLLRHPCSGEPLDRSLV 96

  Fly    87 LWFPGPASFTGEDSCEFQVHGSLAVIAAMLDALGKVDGLRPAEPGEFTKRAFFGGKLDLTEVEGL 151
            ||||||.||||||..|..|||..||::.:|.|||.|.|||||:.||||:|||..|||.|||||||
  Rat    97 LWFPGPQSFTGEDCMELHVHGGPAVVSGVLQALGSVPGLRPAKAGEFTRRAFAHGKLSLTEVEGL 161

  Fly   152 ADLIHAETEAQRKQALLQSTGALARLYDNWRRRLIRCAAHLEAYIDFAEEEQIEGGIILQLGKEL 216
            ||||||||||||:|||.|..|.|::|...|.:.|.:..||:||||||.|::.:|.|::.|:.:::
  Rat   162 ADLIHAETEAQRRQALRQLDGELSQLCQGWAKTLTKALAHVEAYIDFGEDDNLEEGVLEQVDRDV 226

  Fly   217 KAVKREIREHLSDQRQGELLRDGVRTVIIGAPNVGKSSLLNLLCQRSVSIVTDQAGTTRDIIETM 281
            :|::..:..||.|.|:|:.||.|...|:.|.||.|||||:|||.|:.||||:.:.||||||:||.
  Rat   227 RALEVALSSHLRDARRGQRLRSGANVVVAGPPNAGKSSLVNLLSQKPVSIVSPEPGTTRDILETP 291

  Fly   282 HNFGGYPVVFSDTAGLRRYTTDSIEQEGMQRAKNCLVQSDLILLLAEAKNIAQLTH----DDAVA 342
            .:..|:||:.|||||||. ...::||||::||:..|.|:|:||.:.:|.::|..:.    |..||
  Rat   292 VDLAGFPVLLSDTAGLRE-GAGAVEQEGVRRARQRLEQADIILGMLDASDLASSSSCSFLDTVVA 355

  Fly   343 PFV----DSYLGELDIPLDMCSGKRLQLVANKTDTLTDEEHQQLDKLSNVLAISCHKPDKMPVFL 403
            |.|    ||            ..:||.|:.||:|.|:.........|...|.:|||....|...|
  Rat   356 PLVAQSHDS------------GRQRLLLLLNKSDLLSANAPASSTALPPHLLLSCHTGAGMDALL 408

  Fly   404 GSLEKQLQELCGEPRAENPRITNTRYRQQLERCIENIDIFLRDYRPDVYPDMAIAASKLRNSVRC 468
            .:|:.:|..:||:|....|.:|..|::..|:.|::.:..|      .:..|:|:||..||.:.|.
  Rat   409 QALKTELAAVCGDPSTGPPLLTRARHQYHLQGCLDALGRF------QLTTDLALAAEALRQARRQ 467

  Fly   469 IERITGHISCEDILDVVFKDFCIGK 493
            :..:||....|:|||::|:|||:||
  Rat   468 LSHLTGGGGTEEILDLIFQDFCVGK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18528	NP_651251.3	trmE	24..493	CDD:235392	214/476 (45%)
		TrmE_N	24..142	CDD:287381	65/117 (56%)
		trmE	237..415	CDD:206727	73/185 (39%)
Gtpbp3	NP_001011919.1	trmE	35..492	CDD:235392	214/476 (45%)
		TrmE_N	35..152	CDD:287381	65/117 (56%)
		trmE	247..416	CDD:206727	72/181 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351787
Domainoid	1	1.000	260	1.000	Domainoid score	I1910
eggNOG	1	0.900	-	-		E1_COG0486
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6600
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1888
OMA	1	1.010	-	-		QHG62483
OrthoDB	1	1.010	-	-		D280742at33208
OrthoFinder	1	1.000	-	-		FOG0003953
OrthoInspector	1	1.000	-	-		oto96788
orthoMCL	1	0.900	-	-		OOG6_101467
Panther	1	1.100	-	-	LDO	PTHR42714
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2256
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770