Protein Alignment CG6454 and C2CD5

DIOPT Version :10

• Sequence 1: NP_651249.2
• Gene: CG6454 / 42904
• FlyBaseID: FBgn0039187
• Length: 1569
• Species: Drosophila melanogaster
• Sequence 2: XP_016875753.1
• Gene: C2CD5 / 9847
• HGNCID: 29062
• Length: 1161
• Species: Homo sapiens
• Alignment Length: 1660
• Identity: 512/1660 - (30%)
• Similarity: 731/1660 - (44%)
• Gaps: 615/1660 - (37%)

  Fly     1 MPGKVGVKIKAARNLPVMDKSSETTDAFVEIKLASVTHKTDVFRKSLNPTWNTDWFRFEVDDAEL 65
            ||||:.|||.|.|:|||||::|:.||||||:|..:.|.||||:.|||||.||::||:|||||.:|
Human     1 MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEVDDEDL 65

  Fly    66 QDEPLQIRLMDYDTYSANDAIGKVNISLNPLCLESSSQAVHGKGTVLSGWIPVFDTMHGIRGEIN 130
            |||||||.::|:||||||||||||.|.::||....::       ||:|||.|::||:||||||||
Human    66 QDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAA-------TVISGWFPIYDTIHGIRGEIN 123

  Fly   131 VIVKVDLFSDVNKFRQSSCGIPFFHSQCVPFGYRAQVIHGFVEELVVNDDPEYQWIDKIRTPRAS 195
            |:||||||:|:|:|||||||:.||.:..:|..|||.:|||||||||||:||||||||:|||||||
Human   124 VVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVIIHGFVEELVVNEDPEYQWIDRIRTPRAS 188

  Fly   196 NEARQVVFLKLSGQVQRRMGLKAINMGANAVIGYTQCFDLEGDVGVVARGIGTAVTLIKDTSTSQ 260
            |||||.:...:||::||::|||.:.|..|||:||.|||||||:.|:|.|.||||.||.|.:|.:.
Human   189 NEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIGTACTLDKLSSPAA 253

  Fly   261 PNSADVALIEELTQKYLDFLNCAGASNSSLPLSGRTPQYRLNIYREPSSSAPSSAAAAAAATMFY 325
                              ||                          |:.::||
Human   254 ------------------FL--------------------------PACNSPS------------ 262

  Fly   326 LESASSDTEDAELMQNLIRQEDERGDRNREKKLRHRMRRLTLSSSKIFSQKYATLIRRIEPKIPE 390
                                        :|.|                             :||.
Human   263 ----------------------------KEMK-----------------------------EIPF 270

  Fly   391 NATQSLSSIFGGATAATSSFRRRRKSRFAASTSKSSIPPFITRSISSDSNVRPGRMPIKSFLTVP 455
            |
Human   271 N---------------------------------------------------------------- 271

  Fly   456 GLMEYQENTRSAPDLPGDEFQARTRPTSNYSTESEDSLQLDLEIGPPESNAEDSPEEEEDLQDNW 520
                                              ||          |..|...|
Human   272 ----------------------------------ED----------PNPNTHSS----------- 281

  Fly   521 IKPGETRSCENSQQDLGPSHHNLLDDLKGFSRRLQKMMHLSPKSSDIEKKLPFVPSLERKPYYSS 585
               |.:...:|......||        |.:||:
Human   282 ---GPSTPLKNQTYSFSPS--------KSYSRQ-------------------------------- 303

  Fly   586 QPELPSCSNDCLVSNLSGSSSMLQLNFLPSYGKTMQRSASLNHLVAPDTPVPPNTLLLKAPELRV 650
                             .|||...|:..|   ||              .|.|      :.|.:.:
Human   304 -----------------SSSSDTDLSLTP---KT--------------APYP------QGPRIYL 328

  Fly   651 CPSTPTPTQSNLVVFDYNNSPCLTQLDQSVNISNSTNHSNHNNESSLLAPFAIRQQQPPRVIRSS 715
            |||:|:.:..:|    :....||...:.|:     |.|     .|||::|          |:|.|
Human   329 CPSSPSLSCGSL----HLKKSCLLLSESSL-----TPH-----HSSLVSP----------VLRKS 369

  Fly   716 SELQQQPCSTGAAASTGPSNIPTTVEGSSPNLKRFASPVSSSRLKLTPSPSKSGISATTNADSAS 780
            ...                                     |..|.|..|...||
Human   370 VSF-------------------------------------SEELFLAASGMGSG----------- 386

  Fly   781 TSTASTATTMVPATVGEICRRSSDSDLSVTPKGNSICVASERLVAATAMMRLTQPTVGAKPGTAA 845
                                       |...:|...          .|::|  |.|..|
Human   387 ---------------------------SAGKEGGPF----------KALLR--QQTQSA------ 406

  Fly   846 DSLDMLEYPFLTMTKYPTGFILHLGATVAARSVKLLERVPNP----------------------- 887
              |:..|:||.|:|.:|.||::|:|..|:|||||||:|:.||
Human   407 --LEQREFPFFTLTAFPPGFLVHVGGVVSARSVKLLDRIHNPAFVGIMGNTRSYKLLDWNSFNSG 469

  Fly   888 -----------------------DEPEVRDSWWTELRMEIRSHARSLGCNVVLGYAETTTISDDV 929
                                   ||||.||:||.|:|.||:|||::|||:.|:||:|:|:|.::|
Human   470 VQDVSFDGKFIFFKRLAVGMLLSDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEV 534

  Fly   930 CVLSATGTAAVINMVFNRSVSQTDIFTMSKATASVAAMTNSVEDGNGSTAGDTSIGKDSGSLGTG 994
            |:|||:|||||:|..|                         ::||......:..:.::
Human   535 CILSASGTAAVLNPRF-------------------------LQDGTVEGCLEQRLEEN------- 567

  Fly   995 NSSGGKRYGLPPLNGPRNACAICHIPYNLSSVPFNVKMKKCAVCRKGRVPDVLLATLEVPEFMQV 1059
                     ||      ..|..|||||:..::||...:..|..|||.:|||||..|:::|....|
Human   568 ---------LP------TRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATV 617

  Fly  1060 TGRGCFMQAQVVRAKRDLRAELNAKEISDGLPFLEYELHRVLINKLKAKGMNAIFGLRTQVAIGE 1124
            .|:||.:||::.|.|:..:||.||..||:.|||:|||:|..|:||||.|||||:||||.|:.:||
Human   618 IGKGCLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGE 682

  Fly  1125 RMIALIATGTALFLTALPVPQVPKIVAGNSWTD---KQKLNELQKKLQETFERNQEIYQLKSLDP 1186
            .|:..:|:.|.::|.|||.|...:| ||.:..|   :|.::.:|||:.:|..:|:|:|::.  .|
Human   683 NMLMGLASATGVYLAALPTPGGIQI-AGKTPNDGSYEQHISHMQKKINDTIAKNKELYEIN--PP 744

  Fly  1187 DLAANVGGVP---STGASGDKQSDTDDSDEEEMNEIDLNCGNKELCVLEVDDIEDLE-IISLLME 1247
            :::..:.|.|   ....|...:|.::.||  |:.|:||:.|.|:..|||:||.:.:| :.|||.:
Human   745 EISEEIIGSPIPEPRQRSRLLRSQSESSD--EVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTD 807

  Fly  1248 PYPPEGFHVVNTQQVPGMLEMDTVKNLQMFTQVWRARLE----VGQSVNGFPKHF----QRLLQT 1304
            ..||.||:..||:.:||:  .:....:||||.|...||.    ..|::|   |:|    :.||::
Human   808 VPPPSGFYSCNTEIMPGI--NNWTSEIQMFTSVRVIRLSSLNLTNQALN---KNFNDLCENLLKS 867

  Fly  1305 IYFKLRTMIPCAICDLRFRLDLPETDQIQLLVTGMAMGLSDANRMKYRGRGRPAQQQQAPQQQNG 1369
            :|||||:||||.:|.:.|.:.|||.:.||:.||.:|:...         :.:..|..:.|
Human   868 LYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFD---------KNQALQTTKTP----- 918

  Fly  1370 YHDGTVHATQSQPELNGKRMLQEEDYIFPLD--EDQMVDTPTP----------TSTAIP------ 1416
                 |..:..:...:.:.:||     |||:  .|.:...|.|          :::.||
Human   919 -----VEKSLQRASTDNEELLQ-----FPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRAT 973

  Fly  1417 PFGMSSFKMR----------KTSPSRLNNLVSGLPSTGVKPLNVGSVQRSRYFP--LRDRYG-VD 1468
            ....|||..|          |....|..::.:.:......|:..|:. |:|..|  .....| |.
Human   974 SVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMTVEKASPVGDGNF-RNRSAPPCANSTVGVVK 1037

  Fly  1469 VTPLSFIPGGRIDKYLGNLNFFFIRESTSIRENGGISGFVHGFITELLAVVRAHIASLGGNAMVS 1533
            :||||||||.:|.||||.:|.|||||:||:||.||:|||:|.||.|:.|:||||:|:|||||:||
Human  1038 MTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVS 1102

  Fly  1534 FYITELMLFDNQHKNQGQCLISIGGDAVYVSYHAD 1568
            :.:.:.:..:|.:|||.||||::.||||.....:|
Human  1103 YIMKQCVFMENPNKNQAQCLINVSGDAVVFVRESD 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6454	NP_651249.2	C2_KIAA0528-like	5..121	CDD:176070	67/115 (58%)
C2CD5	XP_016875753.1	C2_KIAA0528-like	5..114	CDD:176070	67/115 (58%)