Protein Alignment CG6454 and C2cd5

DIOPT Version :9

• Sequence 1: NP_651249.2
• Gene: CG6454 / 42904
• FlyBaseID: FBgn0039187
• Length: 1569
• Species: Drosophila melanogaster
• Sequence 2: XP_036008278.1
• Gene: C2cd5 / 74741
• MGIID: 1921991
• Length: 1112
• Species: Mus musculus
• Alignment Length: 1614
• Identity: 516/1614 - (31%)
• Similarity: 728/1614 - (45%)
• Gaps: 585/1614 - (36%)

  Fly     1 MPGKVGVKIKAARNLPVMDKSSETTDAFVEIKLASVTHKTDVFRKSLNPTWNTDWFRFEVDDAEL 65
            ||||:.|||.|.|:|||||::|:.||||||:|..:.|.||||:.|||||.||::||:|||||.:|
Mouse     1 MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEVDDEDL 65

  Fly    66 QDEPLQIRLMDYDTYSANDAIGKVNISLNPLCLESSSQAVHGKGTVLSGWIPVFDTMHGIRGEIN 130
            |||||||.::|:||||||||||||.|.::||....::       ||:|||.|::||:||||||||
Mouse    66 QDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAA-------TVISGWFPIYDTIHGIRGEIN 123

  Fly   131 VIVKVDLFSDVNKFRQSSCGIPFFHSQCVPFGYRAQVIHGFVEELVVNDDPEYQWIDKIRTPRAS 195
            |:||||||:|.|:|||||||:.||.:..:|..|||.||||||||||||:||||||||:|||||||
Mouse   124 VVVKVDLFNDSNRFRQSSCGVKFFCTTSIPKCYRAVVIHGFVEELVVNEDPEYQWIDRIRTPRAS 188

  Fly   196 NEARQVVFLKLSGQVQRRMGLKAINMGANAVIGYTQCFDLEGDVGVVARGIGTAVTLIKDTSTSQ 260
            |||||.:...:||::||::|||.:.|..|||:||.|||||||:.|:|.|.||||.||.|.:|.:.
Mouse   189 NEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIGTACTLDKLSSPAA 253

  Fly   261 PNSADVALIEELTQKYLDFLNCAGASNSSLPLSGRTPQYRLNIYREPSSSAPSSAAAAAAATMFY 325
                              ||                          |:.|:||
Mouse   254 ------------------FL--------------------------PACSSPS------------ 262

  Fly   326 LESASSDTEDAELMQNLIRQEDERGDRNREKKLRHRMRRLTLSSSKIFSQKYATLIRRIEPKIPE 390
                                        ||.|                             :||.
Mouse   263 ----------------------------RELK-----------------------------EIPF 270

  Fly   391 NATQSLSSIFGGATAATSSFRRRRKSRFAASTSKSSIPPFITRSISSDSNVRPGRMPIKSFLTVP 455
            |                                             .|.|
Mouse   271 N---------------------------------------------EDPN--------------- 275

  Fly   456 GLMEYQENTRSA-PDLPGDEFQARTRPTSNYSTESEDSLQLDLEIGPPESNAEDSPEEEEDLQDN 519
                  .||.|: |..|.........|:.:||.:|..| ..||.:.|     :.:|..:
Mouse   276 ------PNTHSSGPSTPLKNQTYSFSPSKSYSRQSSSS-DTDLSLTP-----KTAPYPQ------ 322

  Fly   520 WIKPGETRSCENSQQDLGPSHHNLLDDLKGFSRRLQKMMHLSPKSSDIEKKLPFVPSLERKPYYS 584
                             ||.                  ::|.|.|:.:
Mouse   323 -----------------GPG------------------IYLCPSSTPL----------------- 335

  Fly   585 SQPELPSCSNDCLVSNLSGSSSMLQLNFLPSYGKTMQRSASLNHLVAPDTPVPPNTLLLKAPELR 649
                  ||.:..|.|.|...||:
Mouse   336 ------SCGSFHLKSRLLSESSL------------------------------------------ 352

  Fly   650 VCPSTPTPTQSNLVVFDYNNSPCLTQLDQSVNISNSTNHSNHNNESSLLAPFAIRQQQPPRVIRS 714
                  ||..|:||      ||.|.   :||:.|          |...||...:
Mouse   353 ------TPHHSSLV------SPVLR---KSVSFS----------EELFLAASGM----------- 381

  Fly   715 SSELQQQPCSTGAAASTGPSNIPTTVEGSSPNLKRFASPVSSSRLKLTPSPSKSGISATTNADSA 779
                     .:|:|...|                               .|.|
Mouse   382 ---------GSGSAGKEG-------------------------------GPFK------------ 394

  Fly   780 STSTASTATTMVPATVGEICRRSSDSDLSVTPKGNSICVASERLVAATAMMRLTQPTVGAKPGTA 844
                                                            |::|  |.|..|
Mouse   395 ------------------------------------------------ALLR--QQTQSA----- 404

  Fly   845 ADSLDMLEYPFLTMTKYPTGFILHLGATVAARSVKLLERVPNPDEPEVRDSWWTELRMEIRSHAR 909
               |:..|:||||:|.:|.|.::|:|..|:|||||||:|:.||||||.||:||.|:|.||:|||:
Mouse   405 ---LEQREFPFLTLTAFPPGLLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAK 466

  Fly   910 SLGCNVVLGYAETTTISDDVCVLSATGTAAVINMVFNRSVSQTDIFTMSKATASVAAMTNSVEDG 974
            :|||:.|:||:|:|:|.::||:|||:|||||:|..|           :.:.|.. ..:...:|:
Mouse   467 ALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRF-----------LQEGTVE-GCLEQRIEE- 518

  Fly   975 NGSTAGDTSIGKDSGSLGTGNSSGGKRYGLPPLNGPRNACAICHIPYNLSSVPFNVKMKKCAVCR 1039
                                        .||.      .|..|||||:..::||...:..|..||
Mouse   519 ----------------------------NLPV------GCGFCHIPYDELNMPFPAHLTYCYNCR 549

  Fly  1040 KGRVPDVLLATLEVPEFMQVTGRGCFMQAQVVRAKRDLRAELNAKEISDGLPFLEYELHRVLINK 1104
            |.:|||||..|:::|....|.|:||.:||::.|.|:..:||.||..||:.|||:|||:|..|:||
Mouse   550 KQKVPDVLFTTIDLPTDAVVVGKGCLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNK 614

  Fly  1105 LKAKGMNAIFGLRTQVAIGERMIALIATGTALFLTALPVPQVPKIVAGNSWTD---KQKLNELQK 1166
            ||.|||||:||||.|:.:||.|:..:|:.|.::|.|||.|...:| ||.:..|   :|.::.:||
Mouse   615 LKLKGMNALFGLRIQITVGETMLMGLASATGVYLAALPTPGGIQI-AGKTPNDGSYEQHISHMQK 678

  Fly  1167 KLQETFERNQEIYQLKSLDPDLAANVGGVP---STGASGDKQSDTDDSDEEEMNEIDLNCGNKEL 1228
            ::.:|..:|:|:|::  ..|:::..:.|.|   ....|...:|.::.||  |:.|:||:.|.|:.
Mouse   679 RINDTIAKNKELYEI--TPPEVSEEMIGSPIPEPRQRSRLLRSQSESSD--EVTELDLSHGKKDA 739

  Fly  1229 CVLEVDDIEDLE-IISLLMEPYPPEGFHVVNTQQVPGMLEMDTVKNLQMFTQVWRARLE----VG 1288
            .|||:||.:.:| :.|||.:..||.||:..||:.:||:  .:....:||||.|...||.    ..
Mouse   740 FVLEIDDTDAMEDVHSLLTDAPPPSGFYSCNTEIMPGI--NNWTSEIQMFTSVRVVRLSSLNLTN 802

  Fly  1289 QSVNGFPKHF----QRLLQTIYFKLRTMIPCAICDLRFRLDLPETDQIQLLVTGMAMGLSDANRM 1349
            |::|   |:|    :.||:::|||||:|.||.:|.:.|.:.|||.:.||:.||.:|:.. |.|:
Mouse   803 QALN---KNFNGLCENLLKSLYFKLRSMTPCCLCHVNFTVSLPEDELIQVTVTAVAITF-DKNQ- 862

  Fly  1350 KYRGRGRPAQQQQAPQQQNGYHDGTVHATQSQPELNGKRMLQEEDYIFPLD--EDQMVDTPTP-- 1410
                    |.|...|.         |..:..:...:.:.:||     |||:  .|.:...|.|
Mouse   863 --------ALQTTKPH---------VEKSLQRASTDNEELLQ-----FPLELCSDSLPPHPFPAA 905

  Fly  1411 --------TSTAIP------PFGMSSFKMRKTSPSRLNNLVSGLPSTGVKPLNVGSVQ------- 1454
                    :::.||      ....|||..|.:|...|..|.:       :.:..||::
Mouse   906 KEHLESANSNSGIPAAQRATSVDYSSFADRCSSWIELIRLKA-------QTIRRGSIKTTVTVEK 963

  Fly  1455 ---------RSRYFP--LRDRYG-VDVTPLSFIPGGRIDKYLGNLNFFFIRESTSIRENGGISGF 1507
                     |:|..|  .....| |.:||||||||.:|.||||.:|.|||||:||:||.||:|||
Mouse   964 ASAMGDGNFRNRSAPPCASPTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGF 1028

  Fly  1508 VHGFITELLAVVRAHIASLGGNAMVSFYITELMLFDNQHKNQGQCLISIGGDAV 1561
            :|.||.|:.|:||||:|:|||||:||:.:.:.:..:|..|||.||||::.||||
Mouse  1029 LHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPSKNQAQCLINVSGDAV 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6454	NP_651249.2	C2_KIAA0528-like	5..121	CDD:176070	67/115 (58%)
C2cd5	XP_036008278.1	C2_KIAA0528-like	5..114	CDD:176070	67/115 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	468	1.000	Domainoid score	I458
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8873
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1510
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52233
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006290
OrthoInspector	1	1.000	-	-		oto93786
orthoMCL	1	0.900	-	-		OOG6_104702
Panther	1	1.100	-	-	LDO	PTHR37412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3484
SonicParanoid	1	1.000	-	-		X4576
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.000