DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6454 and C2cd5

DIOPT Version :9

Sequence 1:	NP_651249.2	Gene:	CG6454 / 42904	FlyBaseID:	FBgn0039187	Length:	1569	Species:	Drosophila melanogaster
Sequence 2:	XP_038963844.1	Gene:	C2cd5 / 362461	RGDID:	1304592	Length:	1148	Species:	Rattus norvegicus

Alignment Length:	1655	Identity:	517/1655 - (31%)
Similarity:	728/1655 - (43%)	Gaps:	630/1655 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGKVGVKIKAARNLPVMDKSSETTDAFVEIKLASVTHKTDVFRKSLNPTWNTDWFRFE----VD 61
            ||||:.|||.|.|:|||||::|:.||||||:|..:.|.||||:.|||||.||::||:||    ||
  Rat     1 MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEVWFQVD 65

  Fly    62 DAELQDEPLQIRLMDYDTYSANDAIGKVNISLNPLCLESSSQAVHGKGTVLSGWIPVFDTMHGIR 126
            |.:||||||||.::|:||||||||||||.|.::||....::       ||:|||.|::||:||||
  Rat    66 DEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAA-------TVISGWFPIYDTIHGIR 123

  Fly   127 GEINVIVKVDLFSDVNKFRQSSCGIPFFHSQCVPFGYRAQVIHGFVEELVVNDDPEYQWIDKIRT 191
            |||||:||||||:|:|:|||||||:.||.:..:|..|||.||||||||||||:||||||||:|||
  Rat   124 GEINVVVKVDLFNDLNRFRQSSCGVKFFCTTSIPKCYRAVVIHGFVEELVVNEDPEYQWIDRIRT 188

  Fly   192 PRASNEARQVVFLKLSGQVQRRMGLKAINMGANAVIGYTQCFDLEGDVGVVARGIGTAVTLIKDT 256
            |||||||||.:...:||::||::|||.:.|..|||:||.|||||||:.|:|.|.||||.||.|.:
  Rat   189 PRASNEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIGTACTLDKLS 253

  Fly   257 STSQPNSADVALIEELTQKYLDFLNCAGASNSSLPLSGRTPQYRLNIYREPSSSAPSSAAAAAAA 321
            |.:.                  ||                          |:.::||..
  Rat   254 SPAA------------------FL--------------------------PACNSPSKE------ 268

  Fly   322 TMFYLESASSDTEDAELMQNLIRQEDERGDRNREKKLRHRMRRLTLSSSKIFSQKYATLIRRIEP 386
                             |:.:...||...:              |.||.               |
  Rat   269 -----------------MKEIPFNEDPNPN--------------THSSG---------------P 287

  Fly   387 KIP-ENATQSLSSIFGGATAATSSFRRRRKSRFAASTSKSSIPPFITRSISSDSNVRPGRMPIKS 450
            ..| :|.|.|.|
  Rat   288 STPLKNQTYSFS----------------------------------------------------- 299

  Fly   451 FLTVPGLMEYQENTRSAPDLPGDEFQARTRPTSNYSTESEDSLQLDLEIGPPESNAEDSPEEEED 515
                                          |:.:||.:|..| ..||.:.|     :.:|..:
  Rat   300 ------------------------------PSKSYSRQSSSS-DTDLSLTP-----KTAPYPQ-- 326

  Fly   516 LQDNWIKPGETRSCENSQQDLGPSHHNLLDDLKGFSRRLQKMMHLSPKSSDIEKKLPFVPSLERK 580
                                 ||.                  ::|.|.|:.:
  Rat   327 ---------------------GPG------------------VYLCPSSTPL------------- 339

  Fly   581 PYYSSQPELPSCSNDCLVSNLSGSSSMLQLNFLPSYGKTMQRSASLNHLVAPDTPVPPNTLLLKA 645
                      ||.:..|.|.|...||:
  Rat   340 ----------SCGSLHLKSRLLSESSL-------------------------------------- 356

  Fly   646 PELRVCPSTPTPTQSNLVVFDYNNSPCLTQLDQSVNISNSTNHSNHNNESSLLA----------- 699
                      ||..|:||      ||.|.   :||:.|          |...||
  Rat   357 ----------TPHHSSLV------SPVLR---KSVSFS----------EELFLAASGMGSGSAGK 392

  Fly   700 ---PF-AIRQQQPPRVIRSSSELQQQPCSTGAAASTGPSNIPTTVEGSSPNLKRFASPVSSSRLK 760
               || |:.:||      :.|.|:|:                    |.||  .||
  Rat   393 EGGPFKALLRQQ------TQSALEQR--------------------GGSP--PRF---------- 419

  Fly   761 LTPSPSKSGISATTNADSASTSTASTATTMVPATVGEICRRSSDSDLSVTPKGNSICVASERLVA 825
                                                  |||.
  Rat   420 --------------------------------------CRRR----------------------- 423

  Fly   826 ATAMMRLTQPTVGAKPGTAADSLDMLEYPFLTMTKYPTGFILHLGATVAARSVKLLERVPNP--- 887
                                      |:||||:|.:|.|.::|:|..|:|||||||:|:.||
  Rat   424 --------------------------EFPFLTLTAFPPGLLVHVGGVVSARSVKLLDRIHNPAFV 462

  Fly   888 -------------------DEPEVRDSWWTELRMEIRSHARSLGCNVVLGYAETTTISDDVCVLS 933
                               ||||.||:||.|:|.||:|||::|||:.|:||:|:|:|.::||:||
  Rat   463 GIMGNTRSYKLLDWNSFNSDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILS 527

  Fly   934 ATGTAAVINMVFNRSVSQTDIFTMSKATASVAAMTNSVEDGNGSTAGDTSIGKDSGSLGTGNSSG 998
            |:|||||::..|           :.:.|.. ..:...:|:
  Rat   528 ASGTAAVLSPRF-----------LQEGTVE-GCLEQRIEE------------------------- 555

  Fly   999 GKRYGLPPLNGPRNACAICHIPYNLSSVPFNVKMKKCAVCRKGRVPDVLLATLEVPEFMQVTGRG 1063
                .||.      .|..|||||:..::||...:..|..||:.:|||||..|:::|....|.|:|
  Rat   556 ----NLPA------GCGFCHIPYDELNMPFPAHLTHCYNCRRQKVPDVLFTTIDLPTDAVVVGKG 610

  Fly  1064 CFMQAQVVRAKRDLRAELNAKEISDGLPFLEYELHRVLINKLKAKGMNAIFGLRTQVAIGERMIA 1128
            |.:||::.|.|:..:||.||..||:.|||:|||:|..|:||||.|||||:||||.|:.:||.|:.
  Rat   611 CLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLM 675

  Fly  1129 LIATGTALFLTALPVPQVPKIVAGNSWTD---KQKLNELQKKLQETFERNQEIYQLKSLDPDLAA 1190
            .:|:.|.::|.|||.|...:| ||.:..|   :|.::.:|||:.:|..:|:|:|::.  .|::..
  Rat   676 GLASATGVYLAALPTPGGIQI-AGKTPNDGSYEQHISHMQKKINDTIAKNKELYEIN--PPEVCE 737

  Fly  1191 NVGGVP---STGASGDKQSDTDDSDEEEMNEIDLNCGNKELCVLEVDDIEDLE-IISLLMEPYPP 1251
            .:.|.|   ....|...:|.::.||  |:.|:||:.|.|:..|||:||.:.:| :.|||.:..||
  Rat   738 EMIGSPIPEPRQRSRLLRSQSESSD--EVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPP 800

  Fly  1252 EGFHVVNTQQVPGMLEMDTVKNLQMFTQVWRARLE----VGQSVNGFPKHF----QRLLQTIYFK 1308
            .||:..||:.:||:  .:....:||||.|...||.    ..|::|   |:|    :.||:::|||
  Rat   801 SGFYSCNTEIMPGI--NNWTSEIQMFTSVRVVRLSSLNLTNQALN---KNFNGLCENLLKSLYFK 860

  Fly  1309 LRTMIPCAICDLRFRLDLPETDQIQLLVTGMAMGLSDANRMKYRGRGRPAQQQQAPQQQNGYHDG 1373
            ||:|.||.:|.:.|.:.|||.:.||:.||.:|:..               .:.||.|...
  Rat   861 LRSMTPCCLCHVNFTVSLPEDELIQVTVTAVAISF---------------DKHQALQTTK----- 905

  Fly  1374 TVHATQSQPELNGKRMLQEEDYIFPLD--EDQMVDTPTP----------TSTAIP------PFGM 1420
                |..:..|.......|:...|||:  .|.:...|.|          :::.||      ....
  Rat   906 ----TLVEKSLQRASTDNEDGLQFPLELCSDSLPSHPFPAAKEHLESASSNSGIPAAQRATSVDY 966

  Fly  1421 SSFKMRKTSPSRLNNLVSGLPSTGVKPLNVGSVQ----------------RSRYFP--LRDRYG- 1466
            |||..|.:|...|..|.:       :.:..||::                |||..|  .....|
  Rat   967 SSFADRCSSWIELIKLKA-------QTIRRGSIKTTVTVEKASAMGDANSRSRSAPPCASPTVGV 1024

  Fly  1467 VDVTPLSFIPGGRIDKYLGNLNFFFIRESTSIRENGGISGFVHGFITELLAVVRAHIASLGGNAM 1531
            |.:||||||||.:|.||||.:|.|||||:||:||.||:|||:|.||.|:.|:||||:|:|||||:
  Rat  1025 VKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAV 1089

  Fly  1532 VSFYITELMLFDNQHKNQGQCLISIGGDAV 1561
            ||:.:.:.:..:|..|||.||||::.||||
  Rat  1090 VSYIMKQCVFMENPSKNQAQCLINVSGDAV 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6454	NP_651249.2	C2_KIAA0528-like	5..121	CDD:176070	67/119 (56%)
C2cd5	XP_038963844.1	C2_KIAA0528-like	5..118	CDD:176070	67/119 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	452	1.000	Domainoid score	I486
eggNOG	1	0.900	-	-		E1_KOG1031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8873
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG52233
OrthoDB	1	1.010	-	-		D266134at2759
OrthoFinder	1	1.000	-	-		FOG0006290
OrthoInspector	1	1.000	-	-		oto97327
orthoMCL	1	0.900	-	-		OOG6_104702
Panther	1	1.100	-	-	LDO	PTHR37412
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4576
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840