Protein Alignment CG6432 and ACSS1

DIOPT Version :9

• Sequence 1: NP_001287502.1
• Gene: CG6432 / 42901
• FlyBaseID: FBgn0039184
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_115890.2
• Gene: ACSS1 / 84532
• HGNCID: 16091
• Length: 689
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 216/646 - (33%)
• Similarity: 332/646 - (51%)
• Gaps: 63/646 - (9%)

  Fly    34 QSVQNPAAFWEEQGNL----LDWDRPWEKVLD-NSNPPFTKWYVGGYLNACYNSIDRHILAGRGS 93
            |:.:.|||||   |.|    |.||.|:..|.| :.:.....|::||.||...|.:|:|:.....|
Human    64 QAAREPAAFW---GPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPES 125

  Fly    94 NVALIHDSPLTGTLRRVTYQELYDQIVLLAGGLAKLGVVKGDRVVIYMPLIPETIIAMLAIVRLG 158
             ||||.:....||..|:||:||.:....||..|.:.||.:||||.||||:.|..:.||||..|:|
Human   126 -VALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIG 189

  Fly   159 AIHSVVFGGFAARELCSRIEHVEPKLVIASNVGVEPGKVVPYLDILHSAISMSRWRPPQRNII-- 221
            |:|:|:|.||:|..|..||...:.|:||..|.|:..|:||....|:..|:   :..|..::::
Human   190 AVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAV---KHCPTVQHVLVA 251

  Fly   222 FRRDNVSPDTTKLD-PLTDVLWSDILKMAEGERPIACVP--IEANDPLYILYTSGTTDKPKGVLR 283
            .|.|| ......|| ||..       :||: |.|: |.|  :.:.|.|::|||||:|..|||::.
Human   252 HRTDN-KVHMGDLDVPLEQ-------EMAK-EDPV-CAPESMGSEDMLFMLYTSGSTGMPKGIVH 306

  Fly   284 TIGGHLVALVYTLRTLYGINPGHTWWAASDMGWVVGHSYICYGPLCLGATSVMYEGKPDRTPDPG 348
            |..|:|:....|.:.::...||..:...:|:||:.||||:.|||||.|||||::|..| ..|:.|
Human   307 TQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTP-VYPNAG 370

  Fly   349 QYFRIIDQYQVRSIFSVPTSFRVIRRADPDISYG----RQYSMKSLRAIFIAGEHCDYETKSWIE 409
            :|:..:::.::...:..||:.|::      :.||    ::|...|||.:...||..:.|...|:.
Human   371 RYWETVERLKINQFYGAPTAVRLL------LKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLH 429

  Fly   410 KTF---KVPVLNHWWQTETGSAVTATCLGFQQNLSPPTYSTGL---------PLMGYDVKILKAD 462
            :..   :..:::.|||||||    ..|      ::|.....|.         |..|....::...
Human   430 RVVGDSRCTLVDTWWQTETG----GIC------IAPRPSEEGAEILPAMAMRPFFGIVPVLMDEK 484

  Fly   463 GSEAQTSELGRIALKLPLPPGNMATLYKNEELFRTLYFQKFPGYYDTMDAGYKDERGYIFVTARD 527
            ||..:.|.:..........||...|:|.:.:.|...||:.:||||.|.|..|:.|.||..:|.|.
Human   485 GSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRM 549

  Fly   528 DDVINVAGHRLSTSSLEDAVLRHPDVVDVAVFGVPEATKGQVPLCLYIPVENCKKTDAKLSTEII 592
            |||||::||||.|:.:|||:..||.|.:.||.|.|...||:......:..::...:|..:. |:.
Human   550 DDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQ-ELK 613

  Fly   593 KLIRDVVGPIAAFRLVTSVNNLPRTRSGKTMRKAMADFARNERVVL--PATIDDASVFIEI 651
            .::...:...|....:..|..||:|||||.||:.:.....:|...|  ..|::|.|:..||
Human   614 SMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEI 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6432	NP_001287502.1	prpE	28..657	CDD:182517	216/646 (33%)
		PrpE	37..651	CDD:213314	213/641 (33%)
ACSS1	NP_115890.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..46
		Ac_CoA_lig_AcsA	54..676	CDD:274022	216/646 (33%)
		Coenzyme A binding. /evidence=ECO:0000250	224..227		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148550at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820