Protein Alignment CG6432 and ACSS3

DIOPT Version :10

• Sequence 1: NP_651247.1
• Gene: CG6432 / 42901
• FlyBaseID: FBgn0039184
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_078836.1
• Gene: ACSS3 / 79611
• HGNCID: 24723
• Length: 686
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 302/665 - (45%)
• Similarity: 433/665 - (65%)
• Gaps: 29/665 - (4%)

  Fly     3 PGP----------SAVNYEGSESVCGMPVEAHDPLYLKAYRQSVQNPAAFWEEQGNLLDWDRPWE 57
            |||          :..:..|||             |...:..||.:|..||.:....:.|.:||.
Human    40 PGPRGGLGGRGCRALSSGSGSE-------------YKTHFAASVTDPERFWGKAAEQISWYKPWT 91

  Fly    58 KVLDNSNPPFTKWYVGGYLNACYNSIDRHILAGRGSNVALIHDSPLTGTLRRVTYQELYDQIVLL 122
            |.|:|.:.|.|:|:|.|.||.|||::||||..|:|..:|:|:|||:|.|....||:|:.:|:..|
Human    92 KTLENKHSPSTRWFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKL 156

  Fly   123 AGGLAKLGVVKGDRVVIYMPLIPETIIAMLAIVRLGAIHSVVFGGFAARELCSRIEHVEPKLVIA 187
            ||.|.|.|:.|||.||||||:||:.:..|||..|:|||||::|||||::||.|||:||:||:|:.
Human   157 AGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVT 221

  Fly   188 SNVGVEPGKVVPYLDILHSAISMSRWRPPQRNIIFRRDNVSPDTTKLDPLTDVLWSDILKMAEGE 252
            ::.|:|||:.|.|:.::..|:.:.:.: |.:.:|:.|.|:  :...|.|..|:.|.:.:..|:..
Human   222 ASFGIEPGRRVEYVPLVEEALKIGQHK-PDKILIYNRPNM--EAVPLAPGRDLDWDEEMAKAQSH 283

  Fly   253 RPIACVPIEANDPLYILYTSGTTDKPKGVLRTIGGHLVALVYTLRTLYGINPGHTWWAASDMGWV 317
               .|||:.:..|||||||||||..||||:|..||:.|.|.:::.::||:.||..||||||:|||
Human   284 ---DCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWV 345

  Fly   318 VGHSYICYGPLCLGATSVMYEGKPDRTPDPGQYFRIIDQYQVRSIFSVPTSFRVIRRADPDISYG 382
            |||||||||||..|.|:|:|||||..|||.|.|||::.::.|.::|:.||:.|.||:.||..:.|
Human   346 VGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALG 410

  Fly   383 RQYSMKSLRAIFIAGEHCDYETKSWIEKTFKVPVLNHWWQTETGSAVTATCLGFQQNLSPPTYST 447
            :|||:...:.:|:|||.||.||..|.:..|:||||:|||||||||.:||:|:|...:.:||....
Human   411 KQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQA 475

  Fly   448 GLPLMGYDVKILKADGSEAQTSELGRIALKLPLPPGNMATLYKNEELFRTLYFQKFPGYYDTMDA 512
            |..:.||:|.||..:..:.:...||.|.:|||||||..:.|:||:|.|:.|||:|||||||||||
Human   476 GKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDA 540

  Fly   513 GYKDERGYIFVTARDDDVINVAGHRLSTSSLEDAVLRHPDVVDVAVFGVPEATKGQVPLCLYIPV 577
            ||.||.||::|.:|.||||||||||:|..::|:::|.|..|.|.||.|..:..||.|||.|.:..
Human   541 GYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLR 605

  Fly   578 ENCKKTDAKLSTEIIKLIRDVVGPIAAFRLVTSVNNLPRTRSGKTMRKAMADFARNERVVLPATI 642
            ::...|:.::..||:|.:|..:||:||||....|..||:|||||..|.|::.....:...:.:||
Human   606 KDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGKPYKITSTI 670

  Fly   643 DDASVFIEIRRALNQ 657
            :|.|:|..:...|.|
Human   671 EDPSIFGHVEEMLKQ 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6432	NP_651247.1	PrpE	28..651	CDD:341271	294/622 (47%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	294/622 (47%)