DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6432 and aacs

DIOPT Version :9

Sequence 1:	NP_001287502.1	Gene:	CG6432 / 42901	FlyBaseID:	FBgn0039184	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001039244.1	Gene:	aacs / 734109	XenbaseID:	XB-GENE-490085	Length:	672	Species:	Xenopus tropicalis

Alignment Length:	641	Identity:	155/641 - (24%)
Similarity:	277/641 - (43%)	Gaps:	70/641 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YLKAYRQSVQNPAAFWEEQGNLLDWD-------RPWEKVLDNSN--PPFTKWYVGGYLNACYNSI 83
            |.:.|:.||:....||.|     .||       :.:::|:|.|.  ....:|:.|..||...|.:
Frog    46 YNELYQWSVEFYPEFWAE-----FWDFSGIVYSKTYDEVIDRSKGIADVPEWFKGSRLNYAENLL 105

  Fly    84 DRHILAGRGSNVALIHDSPLTGTLRRVTYQELYDQIVLLAGGLAKLGVVKGDRVVIYMPLIPETI 148
             :|   .....:||.........:.:||:.||...:.|.|..:.|:|:..||||..|:|...:|:
Frog   106 -KH---KENDKIALYSAREGKENIEKVTFAELRRDVALFAAAMRKMGIKTGDRVAGYLPNCIQTV 166

  Fly   149 IAMLAIVRLGAIHSVVFGGFAARELCSRIEHVEPKLVIASNVGVEPGKVVPYLDILHSAISMSRW 213
            .||||...:|||.|.....|....:..|...::|||:::....:..||...:|:.|...:   :.
Frog   167 EAMLAAASIGAIWSATSPDFGVNGVLDRFSQIQPKLILSVESVIYNGKEHCHLEKLQHVV---KG 228

  Fly   214 RPPQRNIIFRRDNVSPDTTKLDPLTDVLWSDIL----KMAEGERPIACVPIEANDPLYILYTSGT 274
            .|..:.::.....:..:...:..:.:.::.|..    |:.:....:....:..|.||||:|:|||
Frog   229 LPDLKKVVVIPYVLPKEKIDISKIPNSMFLDEFLATGKVGDQSPQLEFEQLPFNHPLYIMYSSGT 293

  Fly   275 TDKPKGVLRTIGGHLVALVYTLRTLYGINPGHTWWAASDM-------GWVVGHSYICYGPLCLGA 332
            |..||.::.:.||.|:..: |...|:|..      .:||:       ||::.:..|.  .:..||
Frog   294 TGAPKCMVHSAGGTLIKHL-TEHILHGST------TSSDVIMYYTTAGWMMWNWLIT--AVATGA 349

  Fly   333 TSVMYEGKPDRTPDPGQYFRIIDQYQVRSIFSVPTSFRVIRRADPDISYGRQYSMKSLRAIFIAG 397
            :.|:|:|.| ..|.....:.::|:..:..:.:......|:.  |..:.....:|:::|..|...|
Frog   350 SLVLYDGSP-LVPSLNVLWDLVDRLGITILGTGAKWLAVLE--DKGLKPCNTHSLQTLHTILSTG 411

  Fly   398 EHCDYETKSWIEKTFKVPVLNHWWQTETGSAVTATCLGFQQNLSPPTYSTGLPL--MGYDVKILK 460
            .....::..::.|..|..||  ......|:.:.|..:|  ||:|.|.|...:..  :|..::...
Frog   412 SPLKPQSYEYVYKHIKSNVL--LGSVSGGTDIIACFMG--QNVSVPVYKGEIQARHLGMAIEAWN 472

  Fly   461 ADGSEAQTSELGRIALKLPLPPGNMATLYKNEE---LFRTLYFQKFPGYYDTMD-AGYKDERGYI 521
            .:| ||...|.|.:....|||  :..|.:.|:|   .::..||.||||.:...| .....:.|.|
Frog   473 EEG-EAVLGESGELVCLKPLP--SQPTHFWNDENGSKYQKAYFAKFPGVWAHGDYCKINPKTGGI 534

  Fly   522 FVTARDDDVINVAGHRLSTSSLEDAVLRHPDVVDVAVFGVPEATK-GQVPLCLYIPVENCKKTDA 585
            .:..|.|..:|..|.|..:|.:.:.|....:|.|...  ||:..| |...:.|::     |..|.
Frog   535 VMLGRSDGTLNPNGVRFGSSEIYNIVEAFVEVSDSLC--VPQYNKDGDERVILFL-----KMADK 592

  Fly   586 -KLSTEIIKLIRDVVGPIAAFR----LVTSVNNLPRTRSGKTMRKAMADFARNERV 636
             :.|.|::|.|:|.:....:.|    |:....::|.|.|||.:..|:......:.|
Frog   593 FEFSKELLKRIKDAIRVALSARHVPALILETKDIPYTISGKKVEVAVKQVIAGKEV 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6432	NP_001287502.1	prpE	28..657	CDD:182517	155/641 (24%)
CG6432	NP_001287502.1	PrpE	37..651	CDD:213314	151/632 (24%)
aacs	NP_001039244.1	AACS	28..663	CDD:341265	155/641 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910