DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6432 and acss2

DIOPT Version :9

Sequence 1:	NP_001287502.1	Gene:	CG6432 / 42901	FlyBaseID:	FBgn0039184	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001315282.1	Gene:	acss2 / 436914	ZFINID:	ZDB-GENE-040718-388	Length:	698	Species:	Danio rerio

Alignment Length:	700	Identity:	235/700 - (33%)
Similarity:	352/700 - (50%)	Gaps:	76/700 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PGPSAVNYEGSESVCGMPVEAHDP---LYLKAYRQSVQNPAAFWEEQGNLLDWDRPWE-KVLD-- 61
            ||...::..|.     :..|||.|   .|.:.|.:||::|..||.:......|...:. |.||
Zfish     7 PGGDVLHAPGD-----LKKEAHIPSFEKYKELYIKSVESPEEFWADVAKDFFWKTKYTGKFLDYN 66

  Fly    62 ---NSNPPFTKWYVGGYLNACYNSIDRHILAGR-GSNVALIHDSPLTGTLRRVTYQELYDQIVLL 122
               .....:.|...|...|.|||.:||::...: |..||...:....|..:.|||:||..|:...
Zfish    67 FDVTKGEIYIKCMEGATTNICYNVLDRNVHERKLGDRVAFYWEGNEPGDEKTVTYRELLQQVCKF 131

  Fly   123 AGGLAKLGVVKGDRVVIYMPLIPETIIAMLAIVRLGAIHSVVFGGFAARELCSRIEHVEPKLVIA 187
            |..|...||.|||||.||||::.|.::||||..|:||:||:||.||::..||.||...:..|:|.
Zfish   132 ANVLKSQGVKKGDRVSIYMPMVVELVVAMLACARIGAVHSIVFAGFSSESLCERIMDSQCCLLIT 196

  Fly   188 SNVGVEPGKVVPYLDILHSAISMSRWR--PPQRNIIF----RRDNVS------------------ 228
            ::......|::....|...|:...|.:  |.::.|:.    :.|..|
Zfish   197 ADGFYRGDKLINLKLIADEALKKCRDKSFPVEKCIMLKHLTKEDEASSGSLSPPAKRACPDLQQE 261

  Fly   229 -----------PDTTKLDPLTDVLWSDILKMAEGERPIACVPI--EANDPLYILYTSGTTDKPKG 280
                       |.....:|..|:.|..::..|..|    |.|:  ::.|||:||||||:|.||||
Zfish   262 KQKERVRKVRPPPQVPWNPEVDMCWHSLIGGASEE----CEPVWCDSEDPLFILYTSGSTGKPKG 322

  Fly   281 VLRTIGGHLVALVYTLRTLYGINPGHTWWAASDMGWVVGHSYICYGPLCLGATSVMYEGKPDRTP 345
            ||.|:.|:::....|.:.::..:....:|..:|:||:.|||||.||||..|||||::||.| ..|
Zfish   323 VLHTVSGYMLYTASTFKMVFDYHSDDVYWCTADIGWITGHSYITYGPLANGATSVLFEGLP-TYP 386

  Fly   346 DPGQYFRIIDQYQVRSIFSVPTSFRVIRR--ADPDISYGRQYSMKSLRAIFIAGEHCDYETKSWI 408
            |..:.:.|:|:|.|...::.||:.|::.:  :||    ..:|...||:.:...||..:.|...|.
Zfish   387 DVSRMWEIVDKYHVSKFYTAPTAIRLLMKYGSDP----VHKYKRTSLKILGTVGEPINPEAWQWY 447

  Fly   409 -----EKTFKVPVLNHWWQTETGSAVTATCLGFQQNLSPPTYSTGLPLMGYDVKILKADGSEAQT 468
                 ||  :.||::.:||||||..| .|.|.....:.|.  |...|..|....||...|.|.:.
Zfish   448 YNVVGEK--RCPVVDTFWQTETGGHV-MTPLPAATPMKPG--SATFPFFGVVPAILNESGEELEG 507

  Fly   469 SELGRIALKLPLPPGNMATLYKNEELFRTLYFQKFPGYYDTMDAGYKDERGYIFVTARDDDVINV 533
            ...|.:..|.|. ||.|.|:|.|...|.|.||:||||||.|.|...:|:.||.::|.|.||::||
Zfish   508 PSEGYLVFKQPW-PGVMRTVYGNHLRFETTYFKKFPGYYVTGDGCRRDKDGYYWITGRIDDMLNV 571

  Fly   534 AGHRLSTSSLEDAVLRHPDVVDVAVFGVPEATKGQVPLCLYIPVENCKKTDAKLSTEIIKLIRDV 598
            :||.|||:.:|.|::.|..|.:.||.|.|...||:...| ::.:.:....:.||..|:.|.:|:.
Zfish   572 SGHLLSTAEVESALVEHEAVAEAAVVGRPHPVKGESLYC-FVTLNDGINYNQKLEAELKKQVREK 635

  Fly   599 VGPIAAFRLVTSVNNLPRTRSGKTMRKAMADFARNERVVLP-ATIDDASV 647
            :|.||....:.:...||:|||||.||:.:...|.|||.:.. :|:.|:||
Zfish   636 IGAIATPDYIQNAPGLPKTRSGKIMRRVLRKIACNERDLGDVSTLADSSV 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6432	NP_001287502.1	prpE	28..657	CDD:182517	227/671 (34%)
CG6432	NP_001287502.1	PrpE	37..651	CDD:213314	223/662 (34%)
acss2	NP_001315282.1	PRK00174	15..693	CDD:234677	232/691 (34%)
acss2	NP_001315282.1	ACS	34..682	CDD:213313	224/663 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148550at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820