Protein Alignment Dis3 and HELZ2

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: XP_024307774.1
• Gene: HELZ2 / 85441
• HGNCID: 30021
• Length: 2677
• Species: Homo sapiens
• Alignment Length: 810
• Identity: 195/810 - (24%)
• Similarity: 306/810 - (37%)
• Gaps: 233/810 - (28%)

  Fly   179 LLTDDAANRAKA-EAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELL 242
            |..|||..|... |::.::||..       ||.  |:|.::.             |..|....|.
Human  1068 LNADDAILRELLDESQKVMVTVG-------EDG--LLDTVAR-------------PESLQQARLY 1110

  Fly   243 EGL---RQNKLLQGTFQASRENYLEGTVNVEKFEKG------------ILIQGRESLNRAVDGDL 292
            |.|   ...|||    .|..|.|...:...|.||:.            |.::||.....|..||.
Human  1111 ENLPPAALRKLL----HAEPERYRHCSFVPETFERASAIPLDDASSGPIQVRGRLDCGMAFAGDE 1171

  Fly   293 VAVELLPEAEWSAPSEIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVR 357
            |.|:||.                  .|:.| |.|.:                     ||::|:::
Human  1172 VLVQLLS------------------GDKAP-EGRLR---------------------GRVLGVLK 1196

  Fly   358 RKWRQYCGILQ-----PSLIEDTN---RHIFVPADRKIP--------------RIRIETRQAAML 400
            ||..:...:.:     |.::...|   ..||| |:.|.|              |:.:|...|...
Human  1197 RKRHELAFVCRMDTWDPRIMVPINGSVTKIFV-AELKDPSQVPIYSLRKGRLQRVGLERLTAEAR 1260

  Fly   401 QNQRIIVTIDTWPRNSRYPHG-------------HFVRSLG-------PLGDMATENEVILLEHD 445
            .::...|.|..|.:...||.|             ..:|.||       |..|.||..:|:...|
Human  1261 HSRLFWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYH- 1324

  Fly   446 VPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVG 510
                               |.......:|.|.|.....:|||.|..::||||..::| ....||.
Human  1325 -------------------TELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDL-GPRCEVA 1369

  Fly   511 VHIADVSHFIRPGNALDMEAAARGTTVYLVGKR-IDMVPELLSSNLCSLVGGVERFAFSCVWEVD 574
            |||.||:.|:.....||:||..:|...|..|:. :.|:|..|..::.||:.|.:|.|.|....::
Human  1370 VHITDVASFVPRDGVLDVEARRQGAAFYAPGREPVPMLPASLCQDVLSLLPGRDRLAISLFLTME 1434

  Fly   575 NEANVL-SKRFHKSVIKSKRAMTYEEAQNIIDDATQQN-----EIAKSLRNLNR-------LAKI 626
            ..:..| |.||..||::|.|.::||||:.:|    :|:     |:...|.:::.       .:::
Human  1435 KASGQLKSLRFAPSVVQSDRQLSYEEAEEVI----RQHPGAGRELPARLDSVDACVVAACYFSRL 1495

  Fly   627 LKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSE 691
            |::.|:              :.|....:|.|......|..:.||:|:|:..|..|||.:..  ||
Human  1496 LRRHRL--------------RSDCFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVG--SE 1544

  Fly   692 C----AVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSH------------------SLDK 734
            |    ..||..|.|.......|.:.   .|.:|.::  |.|.|                  ||.|
Human  1545 CTRTVTPLRWQPAPRSQQLKALCEK---HGDRVPLS--LHLGHHLHGGGGSPPDTRLHLLASLWK 1604

  Fly   735 CVK--ADNPYFNTMIRILTTRCMMQAVYFISGSLQK---------------EEFFHYGLAAPIYT 782
            .|:  |....:..|:.::||..|...:......|:|               ::..||.|....||
Human  1605 QVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGRCARGHQQQGGHYSLQVDWYT 1669

  Fly   783 HFTSPIRRYSDIMVHR--LLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNT 845
            ..|||||||.|:::.|  |||...|..:..|:.:|     .||...:.:|.:||...|.:.:|:.
Human  1670 WATSPIRRYLDVVLQRQILLALGHGGSAYSARDID-----GLCQAFSLQHALAQSYQRRARSLHL 1729

  Fly   846 HLFFRGKEEDEEGYVLFVR--KNALQVLIP 873
            .:..:.:..|:.|:|:.|.  ....::|.|
Human  1730 AVQLKAQPLDKLGFVVDVEAGSRCFRLLFP 1759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	8/24 (33%)
		VacB	247..946	CDD:440323	178/738 (24%)
HELZ2	XP_024307774.1	zf-C2H2_jaz	39..64	CDD:432381
		DNA2	106..915	CDD:440729
		DEXXQc_HELZ2-N	514..744	CDD:350834
		AAA_12	715..915	CDD:463780
		RNB	1334..1693	CDD:214935	107/384 (28%)
		DEXXc_HELZ2-C	2180..2454	CDD:350798
		AAA_12	2434..2639	CDD:463780