DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and HELZ2

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_024307774.1	Gene:	HELZ2 / 85441	HGNCID:	30021	Length:	2677	Species:	Homo sapiens

Alignment Length:	810	Identity:	195/810 - (24%)
Similarity:	306/810 - (37%)	Gaps:	233/810 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LLTDDAANRAKA-EAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELL 242
            |..|||..|... |::.::||..       ||.  |:|.::.             |..|....|.
Human  1068 LNADDAILRELLDESQKVMVTVG-------EDG--LLDTVAR-------------PESLQQARLY 1110

  Fly   243 EGL---RQNKLLQGTFQASRENYLEGTVNVEKFEKG------------ILIQGRESLNRAVDGDL 292
            |.|   ...|||    .|..|.|...:...|.||:.            |.::||.....|..||.
Human  1111 ENLPPAALRKLL----HAEPERYRHCSFVPETFERASAIPLDDASSGPIQVRGRLDCGMAFAGDE 1171

  Fly   293 VAVELLPEAEWSAPSEIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVR 357
            |.|:||.                  .|:.| |.|.:                     ||::|:::
Human  1172 VLVQLLS------------------GDKAP-EGRLR---------------------GRVLGVLK 1196

  Fly   358 RKWRQYCGILQ-----PSLIEDTN---RHIFVPADRKIP--------------RIRIETRQAAML 400
            ||..:...:.:     |.::...|   ..||| |:.|.|              |:.:|...|...
Human  1197 RKRHELAFVCRMDTWDPRIMVPINGSVTKIFV-AELKDPSQVPIYSLRKGRLQRVGLERLTAEAR 1260

  Fly   401 QNQRIIVTIDTWPRNSRYPHG-------------HFVRSLG-------PLGDMATENEVILLEHD 445
            .::...|.|..|.:...||.|             ..:|.||       |..|.||..:|:...|
Human  1261 HSRLFWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYH- 1324

  Fly   446 VPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVG 510
                               |.......:|.|.|.....:|||.|..::||||..::| ....||.
Human  1325 -------------------TELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDL-GPRCEVA 1369

  Fly   511 VHIADVSHFIRPGNALDMEAAARGTTVYLVGKR-IDMVPELLSSNLCSLVGGVERFAFSCVWEVD 574
            |||.||:.|:.....||:||..:|...|..|:. :.|:|..|..::.||:.|.:|.|.|....::
Human  1370 VHITDVASFVPRDGVLDVEARRQGAAFYAPGREPVPMLPASLCQDVLSLLPGRDRLAISLFLTME 1434

  Fly   575 NEANVL-SKRFHKSVIKSKRAMTYEEAQNIIDDATQQN-----EIAKSLRNLNR-------LAKI 626
            ..:..| |.||..||::|.|.::||||:.:|    :|:     |:...|.:::.       .:::
Human  1435 KASGQLKSLRFAPSVVQSDRQLSYEEAEEVI----RQHPGAGRELPARLDSVDACVVAACYFSRL 1495

  Fly   627 LKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSE 691
            |::.|:              :.|....:|.|......|..:.||:|:|:..|..|||.:..  ||
Human  1496 LRRHRL--------------RSDCFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVG--SE 1544

  Fly   692 C----AVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSH------------------SLDK 734
            |    ..||..|.|.......|.:.   .|.:|.::  |.|.|                  ||.|
Human  1545 CTRTVTPLRWQPAPRSQQLKALCEK---HGDRVPLS--LHLGHHLHGGGGSPPDTRLHLLASLWK 1604

  Fly   735 CVK--ADNPYFNTMIRILTTRCMMQAVYFISGSLQK---------------EEFFHYGLAAPIYT 782
            .|:  |....:..|:.::||..|...:......|:|               ::..||.|....||
Human  1605 QVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGRCARGHQQQGGHYSLQVDWYT 1669

  Fly   783 HFTSPIRRYSDIMVHR--LLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNT 845
            ..|||||||.|:::.|  |||...|..:..|:.:|     .||...:.:|.:||...|.:.:|:.
Human  1670 WATSPIRRYLDVVLQRQILLALGHGGSAYSARDID-----GLCQAFSLQHALAQSYQRRARSLHL 1729

  Fly   846 HLFFRGKEEDEEGYVLFVR--KNALQVLIP 873
            .:..:.:..|:.|:|:.|.  ....::|.|
Human  1730 AVQLKAQPLDKLGFVVDVEAGSRCFRLLFP 1759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	8/24 (33%)
		VacB	249..945	CDD:223631	178/736 (24%)
		RNB	474..802	CDD:279157	106/382 (28%)
HELZ2	XP_024307774.1	ZnF_U1	39..69	CDD:197732
		AAA_11	541..705	CDD:331082
		UvrD_C_2	715..915	CDD:328976
		RNB	1334..1693	CDD:214935	107/384 (28%)
		AAA_11	2180..2427	CDD:315699
		AAA_12	2434..2639	CDD:315700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810