DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and DIS3

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_014621.1	Gene:	DIS3 / 854138	SGDID:	S000005381	Length:	1001	Species:	Saccharomyces cerevisiae

Alignment Length:	991	Identity:	424/991 - (42%)
Similarity:	600/991 - (60%)	Gaps:	92/991 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLREFTRKTKRGNILKIVREHYLRDDIGCGSELCREC-------FQNEVYQLTSQHANKSTLFKF 60
            |.:.|.| ::.|...|||||||||.||.|.|..|.:|       .|||:        .|..|...
Yeast    20 TQKVFVR-SRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNEL--------PKFILSDS 75

  Fly    61 P---------HYLVLDTNVVLDQIDVLEE-DVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRT 115
            |         ||:||||||||..||:||. :...:|:|...||:||:::|..:|.|...:..|..
Yeast    76 PLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSD 140

  Fly   116 --RNFYVFVNEHHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVV 178
              :.|.||.||..:.|:.:|.|:||.|||||||||...:||.:||      |.::      ..||
Yeast   141 DHKRFIVFHNEFSEHTFVERLPNETINDRNDRAIRKTCQWYSEHL------KPYD------INVV 193

  Fly   179 LLTDDAANRAKAEAE---GILVTTAAEYVKSLEDFPLLMDKLSH-KTFDS--EKNGLPQ--YPPH 235
            |:|:|..||..|..|   .|:..:..:|::.|.:...:.|.:.. .:||.  |::....  :|.:
Yeast   194 LVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMDSFDKDLERDTFSDFTFPEY 258

  Fly   236 LSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPE 300
            .|...::.||:...|.||..|.|..|:|||:|::.:|.|.:||.|:::||||.:||.|.|||||:
Yeast   259 YSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQ 323

  Fly   301 AEWSAPSEIVLEEKNVYADEVPSEERAKDE--NEMLNQVRAA-----------ALSAERT----P 348
            :||.|||.|||:.::...::.|..|...|:  ||..:.....           |:.|:|:    |
Yeast   324 SEWKAPSSIVLDSEHFDVNDNPDIEAGDDDDNNESSSNTTVISDKQRRLLAKDAMIAQRSKKIQP 388

  Fly   349 TGRIVGIVRRKWRQYCGILQPSLIE---DTNRHIFV-PADRKIPRIRIETRQAAMLQNQRIIVTI 409
            |.::|.|.||.||||.|.|.||.::   .:.:::|| ..|:.:|::||.||:||.|.::||:::|
Yeast   389 TAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISI 453

  Fly   410 DTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLP------KMPWTITD 468
            |:||...:||.|||||.||.:.....|.|.:||||||.:..||.:||..||      |.|..:.|
Yeast   454 DSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDD 518

  Fly   469 ED-------YSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFIRPGNAL 526
            .:       .:||.||||..|||:|||||.|||||||.|:|||||.|||||||||:||::||.||
Yeast   519 PEAVSKDPLLTKRKDLRDKLICSIDPPGCVDIDDALHAKKLPNGNWEVGVHIADVTHFVKPGTAL 583

  Fly   527 DMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKS 591
            |.|.|||||:||||.|||||:|.||.::||||...|:|||||.:||:|:.||:::..|.||||:|
Yeast   584 DAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRS 648

  Fly   592 KRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPL 656
            :.|.:||:||..|||.||.:|:...:|.|.:|:..||::|::.|||.|||||::..:||||.:|.
Yeast   649 REAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPN 713

  Fly   657 EVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPL--VKSARYQGFQ 719
            |||:|::..|||:||||||||||:||..|...|.:.|:||||..||.|||:.|  :.:.| :...
Yeast   714 EVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTR-KNMS 777

  Fly   720 VDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHF 784
            :.:.|...|:.|||:||..::|||||::||::|||||.|.||.||:....:|.|||||..|||||
Yeast   778 ISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHF 842

  Fly   785 TSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFF 849
            |||||||.|::.||.||.:||.:.......|:...:.:|.|:|.:|:.||:|||||:........
Yeast   843 TSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVM 907

  Fly   850 RGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLK--SDKDGKDGVERVKSEIVFTFNEEDHTQR 912
            |..|..|.|||:.|..|.:.||:||:|:||.:.|.  ::.......:.|:.::.|.....|..:
Yeast   908 RNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPR- 971

  Fly   913 CGDVVFHSFDPVTVRL 928
              ||  :.||.|.|::
Yeast   972 --DV--YVFDKVEVQV 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	81/215 (38%)
		VacB	249..945	CDD:223631	331/718 (46%)
		RNB	474..802	CDD:279157	190/329 (58%)
DIS3	NP_014621.1	PIN_Rrp44-like	25..221	CDD:350211	81/216 (38%)
		Rrp44_CSD1	252..399	CDD:375054	52/146 (36%)
		VacB	281..989	CDD:223631	327/709 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346028
Domainoid	1	1.000	386	1.000	Domainoid score	I99
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6910
Inparanoid	1	1.050	727	1.000	Inparanoid score	I84
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53920
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	1	1.000	-	-		oto100365
orthoMCL	1	0.900	-	-		OOG6_101226
Panther	1	1.100	-	-	LDO	PTHR23355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R319
SonicParanoid	1	1.000	-	-		X1261
TreeFam	1	0.960	-	-
	15	14.790