Protein Alignment Dis3 and DIS3

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_014621.1
• Gene: DIS3 / 854138
• SGDID: S000005381
• Length: 1001
• Species: Saccharomyces cerevisiae
• Alignment Length: 991
• Identity: 424/991 - (42%)
• Similarity: 600/991 - (60%)
• Gaps: 92/991 - (9%)

  Fly     3 TLREFTRKTKRGNILKIVREHYLRDDIGCGSELCREC-------FQNEVYQLTSQHANKSTLFKF 60
            |.:.|.| ::.|...|||||||||.||.|.|..|.:|       .|||:        .|..|...
Yeast    20 TQKVFVR-SRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNEL--------PKFILSDS 75

  Fly    61 P---------HYLVLDTNVVLDQIDVLEE-DVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRT 115
            |         ||:||||||||..||:||. :...:|:|...||:||:::|..:|.|...:..|..
Yeast    76 PLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSD 140

  Fly   116 --RNFYVFVNEHHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVV 178
              :.|.||.||..:.|:.:|.|:||.|||||||||...:||.:||      |.::      ..||
Yeast   141 DHKRFIVFHNEFSEHTFVERLPNETINDRNDRAIRKTCQWYSEHL------KPYD------INVV 193

  Fly   179 LLTDDAANRAKAEAE---GILVTTAAEYVKSLEDFPLLMDKLSH-KTFDS--EKNGLPQ--YPPH 235
            |:|:|..||..|..|   .|:..:..:|::.|.:...:.|.:.. .:||.  |::....  :|.:
Yeast   194 LVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMDSFDKDLERDTFSDFTFPEY 258

  Fly   236 LSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPE 300
            .|...::.||:...|.||..|.|..|:|||:|::.:|.|.:||.|:::||||.:||.|.|||||:
Yeast   259 YSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQ 323

  Fly   301 AEWSAPSEIVLEEKNVYADEVPSEERAKDE--NEMLNQVRAA-----------ALSAERT----P 348
            :||.|||.|||:.::...::.|..|...|:  ||..:.....           |:.|:|:    |
Yeast   324 SEWKAPSSIVLDSEHFDVNDNPDIEAGDDDDNNESSSNTTVISDKQRRLLAKDAMIAQRSKKIQP 388

  Fly   349 TGRIVGIVRRKWRQYCGILQPSLIE---DTNRHIFV-PADRKIPRIRIETRQAAMLQNQRIIVTI 409
            |.::|.|.||.||||.|.|.||.::   .:.:::|| ..|:.:|::||.||:||.|.::||:::|
Yeast   389 TAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISI 453

  Fly   410 DTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLP------KMPWTITD 468
            |:||...:||.|||||.||.:.....|.|.:||||||.:..||.:||..||      |.|..:.|
Yeast   454 DSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDD 518

  Fly   469 ED-------YSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFIRPGNAL 526
            .:       .:||.||||..|||:|||||.|||||||.|:|||||.|||||||||:||::||.||
Yeast   519 PEAVSKDPLLTKRKDLRDKLICSIDPPGCVDIDDALHAKKLPNGNWEVGVHIADVTHFVKPGTAL 583

  Fly   527 DMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKS 591
            |.|.|||||:||||.|||||:|.||.::||||...|:|||||.:||:|:.||:::..|.||||:|
Yeast   584 DAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRS 648

  Fly   592 KRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPL 656
            :.|.:||:||..|||.||.:|:...:|.|.:|:..||::|::.|||.|||||::..:||||.:|.
Yeast   649 REAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPN 713

  Fly   657 EVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPL--VKSARYQGFQ 719
            |||:|::..|||:||||||||||:||..|...|.:.|:||||..||.|||:.|  :.:.| :...
Yeast   714 EVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTR-KNMS 777

  Fly   720 VDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHF 784
            :.:.|...|:.|||:||..::|||||::||::|||||.|.||.||:....:|.|||||..|||||
Yeast   778 ISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHF 842

  Fly   785 TSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFF 849
            |||||||.|::.||.||.:||.:.......|:...:.:|.|:|.:|:.||:|||||:........
Yeast   843 TSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVM 907

  Fly   850 RGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLK--SDKDGKDGVERVKSEIVFTFNEEDHTQR 912
            |..|..|.|||:.|..|.:.||:||:|:||.:.|.  ::.......:.|:.::.|.....|..:
Yeast   908 RNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPR- 971

  Fly   913 CGDVVFHSFDPVTVRL 928
              ||  :.||.|.|::
Yeast   972 --DV--YVFDKVEVQV 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	81/215 (38%)
		VacB	247..946	CDD:440323	331/720 (46%)
DIS3	NP_014621.1	PIN_Rrp44-like	25..221	CDD:350211	81/216 (38%)
		Rrp44_CSD1	252..399	CDD:375054	52/146 (36%)
		OB_Dis3	421..489	CDD:436091	31/67 (46%)
		RNB	531..862	CDD:459934	191/331 (58%)
		Rrp44_S1	912..998	CDD:435792	23/77 (30%)