Protein Alignment Dis3 and SSD1

DIOPT Version :9

• Sequence 1: NP_001262910.1
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_010579.1
• Gene: SSD1 / 851887
• SGDID: S000002701
• Length: 1250
• Species: Saccharomyces cerevisiae
• Alignment Length: 931
• Identity: 221/931 - (23%)
• Similarity: 386/931 - (41%)
• Gaps: 210/931 - (22%)

  Fly   112 HDRTRNFYVFVNEHHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATR 176
            |....:.::..:..|:.:       :|.|  |:.:..:.:.|.:...|..|....|...|
Yeast   242 HGDNDDEFIATSSTHRRS-------KTRN--NEYSPGINSNWRNQSQQPQQQLSPFRHRG----- 292

  Fly   177 VVLLTDDAANRAKAEAEGILVTTAAEY--VKSLEDFPLLMDKLSHK---------TFDSEKNG-- 228
                                 :.:.:|  ..:||  |..:.:..||         :|.|:.|.
Yeast   293 ---------------------SNSRDYNSFNTLE--PPAIFQQGHKHRASNSSVHSFSSQGNNNG 334

  Fly   229 ---LPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVE-KFEKGILIQGRESLNRAVD 289
               ...:.|:|....:.|.:::.:|:.|..:.:::|..:..|:.: ..:..|.|.|.:..|||::
Yeast   335 GGRKSLFAPYLPQANIPELIQEGRLVAGILRVNKKNRSDAWVSTDGALDADIYICGSKDRNRALE 399

  Fly   290 GDLVAVELL-PEAEWSAPSEIVLEEK------NVYADEVP------------------------- 322
            ||||||||| .:..|.:..|  .|||      ::..|.:|
Yeast   400 GDLVAVELLVVDDVWESKKE--KEEKKRRKDASMQHDLIPLNSSDDYHNDASVTAATSNNFLSSP 462

  Fly   323 --SEERAKDE-------NEMLNQ------------VRAAALSAERTPT----------------- 349
              |:..:||:       :..:|.            ||..: |.::.||
Yeast   463 SSSDSLSKDDLSVRRKRSSTINNDSDSLSSPTKSGVRRRS-SLKQRPTQKKNDDVEVEGQSLLLV 526

  Fly   350 --------------GRIVGIVRRKWRQY----CGILQPS--LIEDTNR-------HIFVPADRKI 387
                          |.:|.::.|...|.    .|:|:||  ...|.|:       ..|.|.|:|:
Yeast   527 EEEEINDKYKPLYAGHVVAVLDRIPGQLFSGTLGLLRPSQQANSDNNKPPQSPKIAWFKPTDKKV 591

  Fly   388 PRIRIETRQAA--MLQN------QRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEH 444
            |.|.|.|..|.  .::|      :..:.:|..||..|.:|.|..|..||.:.|..||.:.||.::
Yeast   592 PLIAIPTELAPKDFVENADKYSEKLFVASIKRWPITSLHPFGILVSELGDIHDPDTEIDSILRDN 656

  Fly   445 DVPHCKFSD------EVLSFLPKMPWTITDEDYSKR-VDLRDLYICSVDPPGCTDIDDALHCKEL 502
            :....::.|      |..||.| :|.|....:|.:. .|..:..|.::...|... :.|||.:..
Yeast   657 NFLSNEYLDQKNPQKEKPSFQP-LPLTAESLEYRRNFTDTNEYNIFAISELGWVS-EFALHVRNN 719

  Fly   503 PNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAF 567
            .||.||:|.|:.||:..|..|:::|..|..|.:.|::..|.::::|:..:..| ||..|.|....
Yeast   720 GNGTLELGCHVVDVTSHIEEGSSVDRRARKRSSAVFMPQKLVNLLPQSFNDEL-SLAPGKESATL 783

  Fly   568 SCVWEVDNEA-NVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRR 631
            |.|:.:|:.. .:.|....:|.|.....::.|:    :|:..........|..:..:|:....||
Yeast   784 SVVYTLDSSTLRIKSTWVGESTISPSNILSLEQ----LDEKLSTGSPTSYLSTVQEIARSFYARR 844

  Fly   632 MDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNS--MVEEFMLLANITVAEHIATEFSECAV 694
            :::....|. |.:.. ::|...|.::|::..:..|..  ::.|.....|.||||.|.|:..:.|:
Yeast   845 INDPEATLL-PTLSL-LESLDDEKVKVDLNILDRTLGFVVINEIKRKVNSTVAEKIYTKLGDLAL 907

  Fly   695 LRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAV 759
            |||..:|..|......|..:..|:..|.|:..||...:.| :|.|:  ....|.||..:.|.:|.
Yeast   908 LRRQMQPIATKMASFRKKIQNFGYNFDTNTADELIKGVLK-IKDDD--VRVGIEILLFKTMPRAR 969

  Fly   760 YFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDR-KSNEELC 823
            |||:|.:..:::.||.|..|||||||:|:|||:|.:|||.|.|.| .|:.|.:.::. |...|.|
Yeast   970 YFIAGKVDPDQYGHYALNLPIYTHFTAPMRRYADHVVHRQLKAVI-HDTPYTEDMEALKITSEYC 1033

  Fly   824 HNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEG----------YVLFVRKNALQVLIPKYGLE 878
               |::...|..|...::    ||.. .|..::.|          .||.|.:::..|.||::|:|
Yeast  1034 ---NFKKDCAYQAQEQAI----HLLL-CKTINDMGNTTGQLLTMATVLQVYESSFDVFIPEFGIE 1090

  Fly   879 GTLY------LKSDKDGKDGV 893
            ..::      :|::.||.:.|
Yeast  1091 KRVHGDQLPLIKAEFDGTNRV 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	10/90 (11%)
		VacB	249..945	CDD:223631	199/778 (26%)
		RNB	474..802	CDD:279157	96/331 (29%)
SSD1	NP_010579.1	VacB	505..1149	CDD:223631	166/628 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810