DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and dis3l

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001072835.1	Gene:	dis3l / 780296	XenbaseID:	XB-GENE-1013178	Length:	961	Species:	Xenopus tropicalis

Alignment Length:	927	Identity:	306/927 - (33%)
Similarity:	480/927 - (51%)	Gaps:	114/927 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LTTVLNEVKH-RSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDETANDRNDRAIRLATK 152
            :.|....|:| |....|||...::.|...:..:|.||.....|..||..|:|.....|.|..:..
Frog     1 MQTACQSVQHQRGRRQYKRLCSLLRDTRHDCILFSNEFQNHAYLPREMGESALAWQTRCIYNSCV 65

  Fly   153 WYDDHLQASQSSKEFERSGKAATRVVLLTDDAA--NRAKAEAEGILVTTAAEYVK--------SL 207
            ||..|.|..             ..||::|:|.:  .:...|.:.:.|.:...|::        :|
Frog    66 WYYQHCQKK-------------IPVVMVTEDKSVIRQYNTETQEVYVVSFQIYLETFWPNLKGAL 117

  Fly   208 EDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASREN-YLEGTVNVE- 270
            |.:..|.:....:..:|.:....:||.||.::.|..|::..:..||....::.. .|||.|.::
Frog   118 ELYKSLKETHRERELESREGNGKEYPEHLPLEILEAGIKSGRYQQGVLSVNKHRAQLEGFVRLQG 182

  Fly   271 ------KFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADEVPSEERAKD 329
                  ..:..|||.|.:..|||:.|||||||||..:||...:..:.|.:        ::|:|.|
Frog   183 LGGKETDIQSDILIYGTKPRNRAIHGDLVAVELLSRSEWKGRNGALCENE--------TDEKAVD 239

  Fly   330 ENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIED-------TNRHIFVPADRKI 387
                        ..||..||||:|||::|.||.|.......  ||       ..|.:.:|.|.:|
Frog   240 ------------AQAEVMPTGRVVGILQRNWRDYVATFPAK--EDIETQGKNAQRVLVMPWDYRI 290

  Fly   388 PRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFS 452
            |:|||.|:||..||:.|::|.||:|...|.||:|||||.||..|::..|...||:|:.:....||
Frog   291 PKIRISTQQAEALQDYRVVVRIDSWESTSLYPNGHFVRVLGRTGNLEAEIATILVENSISVNPFS 355

  Fly   453 D----EVLSFLPKMPWTITDEDYSKRVDLRDLY-ICSVDPPGCTDIDDALHCKELPNGNLEVGVH 512
            :    |:.|..|:.||.:..|: ..|:|||..: :.|:||.||.|:||||..::||:|:||:|||
Frog   356 EAQLAEMPSNTPESPWQVKPEE-GDRLDLRKTHLVFSIDPKGCEDVDDALSIRKLPSGHLELGVH 419

  Fly   513 IADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEA 577
            ||||:||:.|....|:||.:|.||.||..:|.||:|.:||::||||:|||:|:|.|.:||:|:..
Frog   420 IADVTHFVPPNTYTDIEARSRATTYYLADRRYDMLPLILSADLCSLLGGVDRYAVSVIWEMDSST 484

  Fly   578 NVLSKRFH-KSVIKSKRAMTYEEAQNIID-----------------DATQQNEIAKSLRNLNRLA 624
            ..:.:.:: :::|:|...::||.||.::|                 |..:..::..::..|..:|
Frog   485 YEIRRVWYGRTIIRSSYKLSYEVAQQLMDGDLEPLNTEMELHPLKQDPVRLEQLLWAVGKLTEVA 549

  Fly   625 KILKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEF 689
            ...:.||..:|||.|...|:|.|: .|.|...::..||..:.:..:.|.|:|||..||:.|...:
Frog   550 HATRMRRDMSGALELEGVEVRVQL-GEKHSIDDLVPKQPLQMHETIAECMILANHWVAKKIWECY 613

  Fly   690 SECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRC 754
            .:.|:||.||......|..|.:.|:.:||.:|..|...|:.|||:.....:|..|.::|::.|:.
Frog   614 PQHALLRLHPPARQEFFQELKECAKARGFSIDTRSNKALADSLDQANDPSDPLVNQLLRMMATQA 678

  Fly   755 MMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSN 819
            |..|.||.:||..::||:|||||...|||||||||||:||:|||||.|::. ......||..|..
Frog   679 MSNARYFSTGSYTEDEFYHYGLALEKYTHFTSPIRRYADIVVHRLLLAAVN-KGPKDNLLGNKDL 742

  Fly   820 EELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEED------EEGYVLFVRKNALQVLIPKYGLE 878
            ||||.::|.|::.||:..:.|..|...:||:.|:.|      .:..:..:|.|.:.:.:|:||::
Frog   743 EELCRHINVRNRAAQHCQKQSTELFQCMFFKDKDPDSDQRCISDAVIYGIRTNGVLLFLPRYGIK 807

  Fly   879 GTLYLKSDKDG-----KD---------GVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLS 929
            |..||| :.||     ||         .::|:...||.|      ||......:..||.||||:.
Frog   808 GAAYLK-NIDGLVLACKDNGRCHWMPGSLQRLPDRIVVT------TQEAKSFSYCLFDHVTVRIH 865

  Fly   930 LDSSNVQHEKLIFRLVK 946
            :.||....:.:...:::
Frog   866 VQSSRFHPDSIRLEIIR 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	28/116 (24%)
		VacB	249..945	CDD:223631	267/753 (35%)
		RNB	474..802	CDD:279157	138/346 (40%)
dis3l	NP_001072835.1	PIN_SF	<1..98	CDD:391943	27/109 (25%)
dis3l	NP_001072835.1	VacB	121..864	CDD:223631	272/774 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1261
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920