Protein Alignment Dis3 and Dis3

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_082591.2
• Gene: Dis3 / 72662
• MGIID: 1919912
• Length: 958
• Species: Mus musculus
• Alignment Length: 993
• Identity: 542/993 - (54%)
• Similarity: 703/993 - (70%)
• Gaps: 57/993 - (5%)

  Fly     5 REFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHA----------NKSTLFK 59
            :.|.:||:.|.::|||||||||||||||:..|..|        ...||          ..|:|..
Mouse     5 KTFLKKTRAGGVVKIVREHYLRDDIGCGAPACSAC--------GGAHAGPALELQPRDQASSLCP 61

  Fly    60 FPHYLVLDTNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNE 124
            :||||:.||||:|.||||||...:|||:||.||:.||::||:.||||..::.:::.::||.|.||
Mouse    62 WPHYLLPDTNVLLHQIDVLEHPAIRNVIVLQTVMQEVRNRSAPIYKRIRDVTNNQEKHFYTFTNE 126

  Fly   125 HHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAK 189
            ||||||.::|..|.||||||||||:|.|||::||:...:..:.:        |:|:|:|..|:.|
Mouse   127 HHKETYIEQEQGENANDRNDRAIRVAAKWYNEHLKRVAADSQLQ--------VILITNDRKNKEK 183

  Fly   190 AEAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQ----YPPHLSMKELLEGLRQNKL 250
            |..|||...|..||||||...|.|:|:|::  ...|.|.:..    :..||.:.:|.:|::....
Mouse   184 AVQEGIPAFTCEEYVKSLTANPELIDRLAY--LSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSY 246

  Fly   251 LQGTFQASRENYLEGTVNV---EKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLE 312
            |||||:||||||||.||.:   ::.||.|||||.:.|||||..|:|||||||.::|.|||.:||:
Mouse   247 LQGTFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLD 311

  Fly   313 EKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNR 377
            ::....|:|..:|    |.|:|  ::.|.......||||:|||::|.||.|||:|..|.|:::.|
Mouse   312 DEGQNEDDVEKDE----ERELL--LKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRR 370

  Fly   378 HIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILL 442
            |:|.|||::|||||||||||:.|:.:||||.||.||||||||:||||::||.:|:..||.||:||
Mouse   371 HLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLL 435

  Fly   443 EHDVPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNL 507
            ||||||..||..||||||:|||:||:||...|.|||.|.:|||||||||||||||||:||.||||
Mouse   436 EHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNL 500

  Fly   508 EVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWE 572
            ||||||||||||||||||||.|:|.|||||||..|||||||||||||||||...|:|.||||:||
Mouse   501 EVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWE 565

  Fly   573 VDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGAL 637
            :::.|.:|..||.||||.||.::||.|||..||.|...::|..|||.||:|||||||.|::.|||
Mouse   566 MNHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGRIEKGAL 630

  Fly   638 VLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPP 702
            .|:||||||.:|||||:|::::.|::||||||||||||||||:||:.|..||||.|:||:||.||
Mouse   631 TLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPP 695

  Fly   703 PTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQ 767
            |:|:|.|||:|:.:..|:..::...|:.|||:....|.||.||::|||.||||||||||.||  .
Mouse   696 PSNYDILVKAAKSKNLQIKTDTAKSLADSLDRAESPDFPYLNTLLRILATRCMMQAVYFCSG--M 758

  Fly   768 KEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKM 832
            ..:|.|||||:|||||||||||||:||:||||||.:||||.||.:|.|:....::|.|||:||||
Mouse   759 DNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLSDICKNLNFRHKM 823

  Fly   833 AQYAGRASVALNTHLFFRGKE-EDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERV 896
            ||||.|||||.:|.|||:.|. ..||.|:|||||||:.|||||||||||::.:         |:.
Mouse   824 AQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFE---------EKD 879

  Fly   897 KSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGT 961
            |.:....:::|..:.|....|||.||.|.|:::|||||:||:|:...||:|.|.|.::....
Mouse   880 KPKPRLAYDDEIPSLRIEGTVFHVFDKVKVKITLDSSNLQHQKIRMALVEPQIPGINIPPNV--- 941

  Fly   962 DSQAVSAAPPSKKTKKDK 979
             :.....||..||.|.:|
Mouse   942 -ADKALTAPGGKKRKLEK 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	94/203 (46%)
		VacB	247..946	CDD:440323	421/702 (60%)
Dis3	NP_082591.2	PIN_Rrp44-like	9..197	CDD:350211	93/197 (47%)
		VacB	206..929	CDD:440323	424/730 (58%)