DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dis3 and Dis3

DIOPT Version :9

Sequence 1:NP_001262910.1 Gene:Dis3 / 42900 FlyBaseID:FBgn0039183 Length:982 Species:Drosophila melanogaster
Sequence 2:NP_082591.2 Gene:Dis3 / 72662 MGIID:1919912 Length:958 Species:Mus musculus


Alignment Length:993 Identity:542/993 - (54%)
Similarity:703/993 - (70%) Gaps:57/993 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 REFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHA----------NKSTLFK 59
            :.|.:||:.|.::|||||||||||||||:..|..|        ...||          ..|:|..
Mouse     5 KTFLKKTRAGGVVKIVREHYLRDDIGCGAPACSAC--------GGAHAGPALELQPRDQASSLCP 61

  Fly    60 FPHYLVLDTNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNE 124
            :||||:.||||:|.||||||...:|||:||.||:.||::||:.||||..::.:::.::||.|.||
Mouse    62 WPHYLLPDTNVLLHQIDVLEHPAIRNVIVLQTVMQEVRNRSAPIYKRIRDVTNNQEKHFYTFTNE 126

  Fly   125 HHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAK 189
            ||||||.::|..|.||||||||||:|.|||::||:...:..:.:        |:|:|:|..|:.|
Mouse   127 HHKETYIEQEQGENANDRNDRAIRVAAKWYNEHLKRVAADSQLQ--------VILITNDRKNKEK 183

  Fly   190 AEAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQ----YPPHLSMKELLEGLRQNKL 250
            |..|||...|..||||||...|.|:|:|::  ...|.|.:..    :..||.:.:|.:|::....
Mouse   184 AVQEGIPAFTCEEYVKSLTANPELIDRLAY--LSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSY 246

  Fly   251 LQGTFQASRENYLEGTVNV---EKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLE 312
            |||||:||||||||.||.:   ::.||.|||||.:.|||||..|:|||||||.::|.|||.:||:
Mouse   247 LQGTFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLD 311

  Fly   313 EKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNR 377
            ::....|:|..:|    |.|:|  ::.|.......||||:|||::|.||.|||:|..|.|:::.|
Mouse   312 DEGQNEDDVEKDE----ERELL--LKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRR 370

  Fly   378 HIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILL 442
            |:|.|||::|||||||||||:.|:.:||||.||.||||||||:||||::||.:|:..||.||:||
Mouse   371 HLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLL 435

  Fly   443 EHDVPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNL 507
            ||||||..||..||||||:|||:||:||...|.|||.|.:|||||||||||||||||:||.||||
Mouse   436 EHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNL 500

  Fly   508 EVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWE 572
            ||||||||||||||||||||.|:|.|||||||..|||||||||||||||||...|:|.||||:||
Mouse   501 EVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWE 565

  Fly   573 VDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGAL 637
            :::.|.:|..||.||||.||.::||.|||..||.|...::|..|||.||:|||||||.|::.|||
Mouse   566 MNHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGRIEKGAL 630

  Fly   638 VLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPP 702
            .|:||||||.:|||||:|::::.|::||||||||||||||||:||:.|..||||.|:||:||.||
Mouse   631 TLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPP 695

  Fly   703 PTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQ 767
            |:|:|.|||:|:.:..|:..::...|:.|||:....|.||.||::|||.||||||||||.||  .
Mouse   696 PSNYDILVKAAKSKNLQIKTDTAKSLADSLDRAESPDFPYLNTLLRILATRCMMQAVYFCSG--M 758

  Fly   768 KEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKM 832
            ..:|.|||||:|||||||||||||:||:||||||.:||||.||.:|.|:....::|.|||:||||
Mouse   759 DNDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLSDICKNLNFRHKM 823

  Fly   833 AQYAGRASVALNTHLFFRGKE-EDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERV 896
            ||||.|||||.:|.|||:.|. ..||.|:|||||||:.|||||||||||::.:         |:.
Mouse   824 AQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFE---------EKD 879

  Fly   897 KSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGT 961
            |.:....:::|..:.|....|||.||.|.|:::|||||:||:|:...||:|.|.|.::....   
Mouse   880 KPKPRLAYDDEIPSLRIEGTVFHVFDKVKVKITLDSSNLQHQKIRMALVEPQIPGINIPPNV--- 941

  Fly   962 DSQAVSAAPPSKKTKKDK 979
             :.....||..||.|.:|
Mouse   942 -ADKALTAPGGKKRKLEK 958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dis3NP_001262910.1 PIN_Rrp44 9..203 CDD:189032 94/203 (46%)
VacB 249..945 CDD:223631 420/699 (60%)
RNB 474..802 CDD:279157 219/327 (67%)
Dis3NP_082591.2 PIN_Rrp44 9..197 CDD:189032 93/197 (47%)
VacB 195..930 CDD:223631 430/742 (58%)
RNB 467..795 CDD:279157 216/327 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849090
Domainoid 1 1.000 448 1.000 Domainoid score I523
eggNOG 1 0.900 - - E1_COG0557
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6910
Inparanoid 1 1.050 1050 1.000 Inparanoid score I260
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53920
OrthoDB 1 1.010 - - D1104619at2759
OrthoFinder 1 1.000 - - FOG0000674
OrthoInspector 1 1.000 - - oto95350
orthoMCL 1 0.900 - - OOG6_101226
Panther 1 1.100 - - LDO PTHR23355
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R319
SonicParanoid 1 1.000 - - X1261
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.800

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