Protein Alignment Dis3 and dis3l2

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: XP_005163305.1
• Gene: dis3l2 / 566106
• ZFINID: ZDB-GENE-070705-171
• Length: 995
• Species: Danio rerio
• Alignment Length: 1025
• Identity: 304/1025 - (29%)
• Similarity: 479/1025 - (46%)
• Gaps: 174/1025 - (16%)

  Fly    41 QNEVY-QLTSQHANKSTLFKFPHYLVLDTNVVLDQIDVLEEDVLRNVV--VLTTVLNEVK--HRS 100
            |.:.| :|.:||.|.    ||..||.          :.:|:....|..  |..:..|..|  |..
Zfish    26 QKDAYSRLLNQHQNG----KFRSYLQ----------EFVEQQSEENATTSVSRSDANRRKKGHSE 76

  Fly   101 SAIY--------------KRFNEIVHDRTRNFYVFVNEHHKETYADREPDETANDRNDRAIRLAT 151
            |:.:              ..||....|:|         .|:.|.|: :|..............|.
Zfish    77 SSYFGDSVSSPQSRPMLADTFNSFHADKT---------FHQVTCAE-DPGTNPGMLEKLHKGSAP 131

  Fly   152 KWYDDHLQASQSSKEFERSGKAATRVVLLTDDAA-----------NRAKAE-------------- 191
            |      :||...|:.|:..||:|.:|...:..|           .|.|::
Zfish   132 K------KASAKLKKSEKDIKASTSLVGSEEGDAQQLSGSCGEEKTRKKSKKKSSKGHLEKKDKG 190

  Fly   192 AEGILVTTAAEYV-KSLEDFPLL-----MDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKL 250
            |.|:.|..|.:.. |:::....|     :||......|...:|...:..::|::::..||::.:|
Zfish   191 ACGLEVDAAEKSANKNVKASQALKGSRQIDKKDINAKDGRASGKQVFEQYMSVEDVSAGLKRGEL 255

  Fly   251 LQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLP--------------EA 301
            :||..:.:.:.|.|..:........|.:.|..:.|||::||:|.|::||              ||
Zfish   256 IQGVLRINPKKYKEAYIPSPDGSADIFLDGISARNRALNGDVVVVKVLPLEQSQATKTPDVIVEA 320

  Fly   302 EWSAPSEIVLEEKNVYADE-----VPSEERAKDENEMLNQVRAAALSAERT--PTGRIVGIVRRK 359
            .::...|:|.:.:.|..::     ..|.|.|...|       ..|.|:|||  ..|::|.||.:|
Zfish   321 HYNGDDEMVSKMEKVSLNDKALLTTQSVEHATTSN-------TPASSSERTTQKNGKVVFIVEKK 378

  Fly   360 W-RQYCGILQPSLIEDTNRHIFVPADRKIPRIRIE--------TRQAAMLQNQRIIVTIDTWPRN 415
            . |...|.|:  .:.:....:|.|.|.::||:.:.        |.:....:|...|..|..||.:
Zfish   379 HSRAVSGFLK--FLPNKRFAMFSPVDHRVPRVNVPLADCPADFTSRPGDYENTLFICRITQWPAD 441

  Fly   416 SRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLPK-MPWTITDEDYSKRVDLRD 479
            |.:..|...::||..|::..|.|.||.|:.|...:|::|||:.||: :||:|...:.|.|.|||.
Zfish   442 SNFAEGRLAKTLGQAGEIEPETEGILTEYGVDFSEFTEEVLNCLPQDLPWSIPAHELSTRRDLRK 506

  Fly   480 LYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRI 544
            ..|.::||....|:||||.||:|.:||.||||||||||:|::.|||||..|..|.|:||||.|.|
Zfish   507 ECIFTIDPATARDLDDALSCKQLSDGNFEVGVHIADVSYFVKEGNALDELAGQRATSVYLVQKVI 571

  Fly   545 DMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNIID---- 605
            .|:|.||...||||....:|..||.:|::..|..:||:.|.::||.|...::|:.||::||
Zfish   572 PMLPRLLCEELCSLNPLTDRLTFSVIWKLSPEGKILSEWFGRTVICSCIKLSYDHAQSMIDAPDK 636

  Fly   606 -------DATQQN----EIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPLEVE 659
                   .|...|    ||.:::.||:.:||.|:.:|.:.|||.|...::.|.:|.|:..|....
Zfish   637 HFSPEELPACSPNHSIIEIQEAVLNLHNIAKQLRAQRFEGGALRLDQLKLSFTLDKESSMPQGCY 701

  Fly   660 VKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINS 724
            |.|.|::|.:|||||||||:.|...|...:.|.|:|||||.|.....|.:.:.....|..:|.:|
Zfish   702 VYQYRDSNKLVEEFMLLANMAVGHQIYRSYPELALLRRHPPPQTKMVDDMQEFFDQMGLDIDFSS 766

  Fly   725 GLELSHSLDKCVKADNPYFNTMIRILTTRC---MMQAVYFISGSLQKEEFF-HYGLAAPIYTHFT 785
            ...|..||::.: .|:.|......::|..|   |..||||.:|:|:.|:.| ||.|..|:|||||
Zfish   767 SGALHRSLNENL-GDDEYTAARKEVITHMCSRPMQMAVYFCAGALKDEKLFRHYALNVPLYTHFT 830

  Fly   786 SPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVA------LN 844
            ||||||:|::|||||.||:......:     .|.||:       |:.|.:......|      |:
Zfish   831 SPIRRYADVIVHRLLGASLNCGPRLS-----VSGEEV-------HQQASHCNDRKTASKRVQELS 883

  Fly   845 THLFFR--GKE---EDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERV-------K 897
            :.|||.  .||   .|.|..|:.|...:..||:.:||::..:|..|    .:|::.|       |
Zfish   884 SELFFAVFVKECGPLDSEAMVMGVLDQSFDVLVLRYGVQKRIYCNS----LEGLKEVEFRKVGKK 944

  Fly   898 SEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKP 947
            .|:...:..:|.::.........|..:.|:|..|.:.:::...:.|.:.|
Zfish   945 PEMTLVWETDDPSKDSIKQEISIFTLLNVQLKADGAPMKYSATLKRPLAP 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	42/205 (20%)
		VacB	247..946	CDD:440323	252/766 (33%)
dis3l2	XP_005163305.1	VacB	251..872	CDD:440323	225/642 (35%)
		Dis3l2_C_term	896..986	CDD:465547	19/93 (20%)