DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dis3 and helz2a

DIOPT Version :9

Sequence 1:NP_001262910.1 Gene:Dis3 / 42900 FlyBaseID:FBgn0039183 Length:982 Species:Drosophila melanogaster
Sequence 2:XP_003198895.2 Gene:helz2a / 562461 ZFINID:ZDB-GENE-120920-1 Length:2656 Species:Danio rerio


Alignment Length:1010 Identity:230/1010 - (22%)
Similarity:387/1010 - (38%) Gaps:262/1010 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RKTKRGNILKIVREHYL--RDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVV 71
            |.||  :|:..|..|:.  |.|:...        :..|.....|||     .:|.|   :.....
Zfish   846 RSTK--DIVDFVSTHFYVGRSDVIKA--------RGNVPSHPQQHA-----LQFHH---VRGECC 892

  Fly    72 LDQIDVL---EEDVLRNVVVLTTVLNE-------VKHRSSAIYKRFNEIVHDRTR-------NFY 119
            ||.:.:.   .|.::|.|.:|..::.|       ....|..:..:..:::..|.|       .|.
Zfish   893 LDPMSMSWFNAEQIVRVVHILQEIMKEWPQEWGAADPESVCVLSQGRQVLEIRYRLRLLGLPRFT 957

  Fly   120 VFVNEHHKETYADREPDETANDRNDRAIRLAT-KWYDDHLQASQSSKEFERS--------GKAAT 175
            |             |..|....:..|.|.::| ...|..|:..::..||...        .:|.:
Zfish   958 V-------------ENAENVQGKQFRVIVISTVHTKDSLLETDRTCLEFFNDMRVLNTIMTRAQS 1009

  Fly   176 RVVLLTDDAANRAKAEAEGILVTTAAEYVK--------------SLEDFPLLMDKL----SHKTF 222
            ::.::.|.||  ......|:.......|::              ||:...|.:.||    ..:..
Zfish  1010 QIFVVGDAAA--LSCHQFGMCWRLWRAYIEECINKESCHDLTLDSLKQDLLEISKLCRSEDEENS 1072

  Fly   223 DSEK--NGLPQYPPHLSMKELL------------EGL-----RQNKLLQGTFQASRENYLE---- 264
            |||.  :.||. ...|.::|||            |||     .|........|.:...|.|    
Zfish  1073 DSESTTSELPD-TEDLILQELLDESKEINVALTEEGLFPVFQNQEAFSSANNQVAEVYYEEPMFT 1136

  Fly   265 -GTVN------VEKFEKG-----------ILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEI-- 309
             .||:      .|.:::|           |.|:||.::.||..||.|.||:|..........:  
Zfish  1137 SSTVHKQCEIVKEGYDRGYAKPLDESTLRIDIKGRANIGRAFPGDKVTVEILSATSHPPMGRVIN 1201

  Fly   310 VLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGR-IVGIVRRKWRQYCGILQPSLIE 373
            :||..:...:.|.:.||  .:|:::            ||..: |..|....|:            
Zfish  1202 ILESADTVKEFVCALER--HDNQVM------------TPINKCITKIFTPFWK------------ 1240

  Fly   374 DTNRHIFV--PADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATE 436
            |...||.|  |...|:.:. |:..:.|. :....||.:.:|....|||.|..|   |.|..:||.
Zfish  1241 DKPNHIAVRNPESLKVEKF-IKINEEAH-RKSLFIVKVLSWRNVFRYPLGIVV---GVLPKIATL 1300

  Fly   437 NE---VILLEHDVPHCKFSD--EVLSFLPKMPWTITDEDYSK-RVDLRDLYICSVDPPGCTDIDD 495
            ::   |:.:|:.:.....|.  :.:.:|.::      :.:.| |.|.|.|...:|||....|:||
Zfish  1301 DDGLHVLSIEYQLRRTLSSSLRKQMQYLQRL------DIFEKGRRDFRMLPTFTVDPAHSQDLDD 1359

  Fly   496 ALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKR-IDMVPELLSSNLCSLV 559
            |:..::. ...||:||||:||:.|:...:.||..|....||.|...|. |.|.|:.||:||.||:
Zfish  1360 AISLQDF-GEYLEIGVHISDVASFVAKDSELDKFARQLCTTFYPREKEPIYMFPKELSTNLLSLI 1423

  Fly   560 GGVERFAFSCVWEVDNEANVLSKRF-HKSVIKSKRAMTYEEAQNIIDDATQQNEIAK-SLRNLNR 622
            ...:|.|.|.:.|||.:.|.:.:|| .||||.|.|..:|:|.::|:::....:::.: .|..::.
Zfish  1424 PNQDRRAISLIIEVDAQTNRIKRRFICKSVIHSNRKFSYDEVEDILENGEPLSDLLEICLVKVSN 1488

  Fly   623 LAKILKK-RRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIA 686
            .|::.:: |:.|:....:...::..               ..|.::.||||.|::.|..|||.:.
Zfish  1489 FAEVHRRYRKQDDWCYKMPDEDVTL---------------GRRRSHQMVEELMVMFNHMVAERLL 1538

  Fly   687 TEFS--ECAVLRRHPRPPPTNFDPLV----KSARYQGFQVDINSGLELSHSLDK--------CVK 737
            ::.:  ....||...||   ..|.|:    |:|......|..:|   .:|.|:|        ...
Zfish  1539 SDGATRSKTPLRCQDRP---QTDKLIEIFDKNAALIPLSVHFSS---QAHELNKQGLIQHNPQTD 1597

  Fly   738 ADN-PYFNTMIRILTTRCMMQAVYFI-------------------------------SGSLQKEE 770
            :|. |...:::|.|.:....:.:|.|                               |.|.....
Zfish  1598 SDTFPVLKSILRCLKSAAEQENIYKIIDFVATDDIHPQLLPFAVAFRRLFHKACIQRSNSTHVSR 1662

  Fly   771 FFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIG-ADSTYAQL--------LDRKSNEELCHNL 826
            ..||.|....||..:||:|||.|::|.|||.:.|. .|..|..|        ..||::::..:. 
Zfish  1663 IGHYDLDLDSYTWASSPVRRYLDVIVQRLLHSVIDKTDVKYTTLDINLSCLEFSRKNDQQSAYE- 1726

  Fly   827 NYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVL 861
                       |.:.||:..|....:.|.:..|::
Zfish  1727 -----------RKANALHFALKLSSQSERKVAYIV 1750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dis3NP_001262910.1 PIN_Rrp44 9..203 CDD:189032 40/221 (18%)
VacB 249..945 CDD:223631 171/705 (24%)
RNB 474..802 CDD:279157 104/377 (28%)
helz2aXP_003198895.2 AAA_11 614..807 CDD:289831
P-loop_NTPase 639..>683 CDD:304359
DNA2 <741..1055 CDD:224037 43/241 (18%)
UvrD_C_2 817..1017 CDD:304668 36/201 (18%)
RNB 1338..1698 CDD:214935 105/381 (28%)
AAA_11 2168..2405 CDD:289831
AAA_19 2176..2246 CDD:289986
P-loop_NTPase <2366..2438 CDD:304359
AAA_12 2414..2614 CDD:289832
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0557
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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