DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dis3 and dis3l

DIOPT Version :9

Sequence 1:NP_001262910.1 Gene:Dis3 / 42900 FlyBaseID:FBgn0039183 Length:982 Species:Drosophila melanogaster
Sequence 2:NP_001103928.1 Gene:dis3l / 560362 ZFINID:ZDB-GENE-070209-95 Length:1057 Species:Danio rerio


Alignment Length:1059 Identity:353/1059 - (33%)
Similarity:555/1059 - (52%) Gaps:142/1059 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQI 75
            :.:|..:::|||||:|:.:.|||.||:...|| |.::.|:...        ||:|.|..||.|.:
Zfish    12 SSKGRKVRVVREHYMREQVPCGSSLCQADCQN-VGKVLSRDVT--------HYVVPDVGVVRDFL 67

  Fly    76 DVLEEDVLRNVVVLTTVLNEVKH-RSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDETA 139
            ::||...|:.:|:..|....|:| |....|.|...::.|...:..:|.||..:.:|..||..|:.
Zfish    68 EILELRELQGIVLTQTAYQTVQHTRGRRHYNRLRSLLKDPRHDCVLFANEFQQYSYCPREKGESQ 132

  Fly   140 NDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTD--DAANRAKAEAEGILVTTAAE 202
            :..:.|.:..|..||.:||...|.             ||::|:  ||.:...|...|:.|.:..|
Zfish   133 DKWHTRNVYNAAVWYYNHLAGLQP-------------VVMITEDRDAISEFSASNSGVFVISTQE 184

  Fly   203 YVKSLEDFPLLMDKLSHKTFDS--------EKNGLPQ-YPPHLSMKELLEGLRQNKLLQGTF--- 255
            |:  |..:|.|  :.:|..:.|        |.:|..: |..||..:.|..|::..:.:||..   
Zfish   185 YL--LGFWPDL--QAAHDLYHSIAQTLQERENDGAEKVYTEHLPAEVLEAGIKSGRYIQGILSVN 245

  Fly   256 --QASRENYL--EGTV--NVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEK 314
              :|..|.::  ||:.  |.| ....:||.|.:..||||.||:|.:||||..||..        :
Zfish   246 KHRAQHEAFVRYEGSASKNTE-LNSDVLINGAKHRNRAVHGDVVVIELLPRNEWKG--------R 301

  Fly   315 NVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQP-----SLIED 374
            .:...|...|||..::.:           ::..||||:|.|::|.||.|...|.|     |...:
Zfish   302 TMALTEGQGEERPLEDTQ-----------SQPMPTGRVVEILQRNWRDYVVTLPPFEEMQSQSRN 355

  Fly   375 TNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEV 439
            :.:.:.||.|.:||:|||.|:||..||:||:||.:|:|...|.||:|||||.||..|::.||.:.
Zfish   356 SQKILVVPWDYRIPKIRISTQQAEALQDQRVIVRLDSWESTSVYPNGHFVRVLGKSGELETEIQT 420

  Fly   440 ILLEHDVPHCKFSDEVLSFLP----KMPWTITDEDYSKRVDLRDLY-ICSVDPPGCTDIDDALHC 499
            ||:|:.:....||:..|..:|    :.||.:...:.|.|.||||.: :.|:||.||.|:||.|..
Zfish   421 ILVENCIHVPPFSEAQLREMPVNTEENPWQMDSNEVSSRRDLRDSHLVFSIDPKGCEDVDDTLSV 485

  Fly   500 KELPNG-NLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVE 563
            :.||.| .||:|||||||:||:|.|:..|:||.:|.||.||..:|.||:|.:||::||||:|||:
Zfish   486 RTLPGGKRLELGVHIADVTHFVREGSLTDLEARSRATTYYLADRRYDMLPAVLSADLCSLLGGVD 550

  Fly   564 RFAFSCVWEVDNEA-NVLSKRFHKSVIKSKRAMTYEEAQNIIDDA----------------TQQN 611
            |:|.|.:||:|.|. .|.|..|.:::|:|...:.||.||::::..                .:.:
Zfish   551 RYAMSVLWELDAETLEVCSVWFGRTLIRSSYQLHYELAQSLLNGEEVEVPELNPLKGSQRDQKMS 615

  Fly   612 EIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLL 676
            |:.::|..|.|:|:.|:.:|...|||.|...|:|.|:|.|.:....|. ||..|.:..|.|.|:.
Zfish   616 ELLQALETLTRVARHLRAQRDKGGALELEGVEVRAQLDEEKNITALVP-KQPLEVHETVAECMIY 679

  Fly   677 ANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNP 741
            ||..||..|...|...|:||.||.|....|:.|:.||:..||.:|..|...|:.||::.|...:|
Zfish   680 ANHWVARKIQESFPHHALLRHHPPPKQEFFNHLIDSAKAHGFSIDTRSNRALADSLERAVDPRDP 744

  Fly   742 YFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGA 806
            ..|.::|::.|:.|..|:||.:||..:|:::|||||...|||||||||||:|::|||||.|::..
Zfish   745 LVNRLLRMMATQAMSNALYFSTGSCPEEQYYHYGLALARYTHFTSPIRRYADVIVHRLLMAAVQL 809

  Fly   807 ---DSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEE--DE----EGYVLF 862
               :|....|...|..|||..::|.:::.||::.:.|:.|...::||.|:.  ||    :..:..
Zfish   810 EKDESPSKALACNKELEELAQHINNKNRAAQHSQKQSIELFQCMYFRDKDSHTDERCVADAVIYA 874

  Fly   863 VRKNALQVLIPKYGLEGTLYLKSDKDGK------DG--------VERVKSEIVFTFNEEDHTQRC 913
            ||.|.....:|:|||:|.:||| |::|:      ||        :::...:|:.:.:...||   
Zfish   875 VRANGFLAFVPQYGLKGAVYLK-DREGQVISVDGDGKCEWKPGTLQKYSDKIITSTSTGTHT--- 935

  Fly   914 GDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLV--KPYI-------------KGFSVETTTEGTDS 963
                |:.|:.||||:|::.|....:.|...|:  ||:.             .|...|......::
Zfish   936 ----FYLFNHVTVRISVEPSRCHADSLNLELISNKPHCAVQPESQPAGGGRSGLVEEVVRWAEEA 996

  Fly   964 QAVSAAPPSKKTKKDKKKK 982
            ...:.....:|.|..|::|
Zfish   997 SLQAEEQRGRKPKLSKEEK 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dis3NP_001262910.1 PIN_Rrp44 9..203 CDD:189032 56/194 (29%)
VacB 249..945 CDD:223631 274/755 (36%)
RNB 474..802 CDD:279157 147/346 (42%)
dis3lNP_001103928.1 PIN_SF 12..185 CDD:301351 56/194 (29%)
VacB 159..946 CDD:223631 290/819 (35%)
RNB 459..806 CDD:279157 147/347 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 998..1017 4/18 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0557
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1104619at2759
OrthoFinder 1 1.000 - - FOG0000674
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1261
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.820

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