DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and Dis3l2

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_728490.1	Gene:	Dis3l2 / 38034	FlyBaseID:	FBgn0035111	Length:	1044	Species:	Drosophila melanogaster

Alignment Length:	914	Identity:	252/914 - (27%)
Similarity:	404/914 - (44%)	Gaps:	190/914 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 LRN-VVVLTTVLNEVKHRSSAIYK------RFNEIVHDRTRNFYVFVNEHHKETYADREPDET-- 138
            ||| |..|..::..:.|.|..:..      |.|||:...          ...:|.::..|.:.
  Fly   157 LRNEVEALQDMVKHLSHLSPDVNAYACQLIRKNEILSQL----------EWSQTRSEAHPQQVGY 211

  Fly   139 -ANDRNDRAIRLATKWYDDHLQ-------ASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGI 195
             ...|:|..:.....  ..|:|       ..::||:.:.||...|:          ..|.|.|.:
  Fly   212 QGRHRHDSEVSATNN--GSHVQQQPKLGRRQRNSKKNDGSGSNGTQ----------SQKTELEAM 264

  Fly   196 LVTTAAEYVKSLEDFPLLMDKLSHKTFDSE----KNGLPQYPPHLSMKELLEGLRQNKLLQGTFQ 256
                 ..|:..:....:.||   |:.  ||    |........|   .:.|......::::...:
  Fly   265 -----RSYINKIVQRHVGMD---HQL--SEDLIFKGNFSDLEAH---AQRLVAAGYGRIVEEEIR 316

  Fly   257 ASRENYLEGTVNVEKFEKGILIQGRESLNR------------AVDGDLV-AVELLPEAEWSA--- 305
            .:|:|..:..:        |:...||:|.|            |.|||.| |..|.|.|:.|:
  Fly   317 VNRKNNRQAFI--------IMSTDREALERDGIVLLPVARRYAFDGDKVRAFVLNPGAQGSSKTA 373

  Fly   306 -PS---------EIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRR-K 359
             ||         .:.|.:....:|:..|:....|.:.::      .:|::..|...::.|.:| :
  Fly   374 EPSSGEISGGKPSLSLADGEELSDDTESQGSESDTDNVV------VISSDNCPKAFVIAITKRTE 432

  Fly   360 WRQYCGILQ----PSLIEDTNRHIFVPADRKIPRIRI-ETRQAAMLQN-QRI----------IVT 408
            .||..|.:.    ..|.:|...:.|.|.|.::|.:.: :...||.:.| |:|          |:.
  Fly   433 LRQIVGTISFTNPTKLCDDQLFYKFRPYDLRVPMVYVPKDACAAHIGNKQQIDVSGLLYLAHILE 497

  Fly   409 IDTWPRNSRYPHGH----FVRSLGPLGDMATENEVILLEHDVPHCK-FSDEVLSFLPKMPWTITD 468
            .|.        :||    .::.:|.:|::..|.:.||..:.:...| |....:....:.|..|:.
  Fly   498 TDC--------NGHCIAELIQPVGRVGNLDDELKAILFHNGLRDIKPFEQRFIDIYSQPPPPISQ 554

  Fly   469 EDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAAR 533
            ||..:|.|||.:.|.::||....|:|||:..::|.:...|:||||:|||||:...|.||.....|
  Fly   555 EDLRQRKDLRKMCIFTIDPMTARDLDDAVSIEKLGDNEYEIGVHISDVSHFLIEDNELDNIVKER 619

  Fly   534 GTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKR--FHKSVIKSKRAMT 596
            .|::||..:.|.|:|:.|... |||:.|.::||||..|.::.:..:|.|:  |.::||.|.....
  Fly   620 STSIYLANEVIHMLPQSLCMR-CSLLPGQDKFAFSVFWRMNGKGVMLQKKPEFCRTVINSCSQFA 683

  Fly   597 YEEAQNIIDDATQ---QNEI--------AKSLRN----LNRLAKILKKRRMDNGALVLASPEIRF 646
            ||.||.|||:..:   :|:.        ...:||    |:.:|..::|.|:|||||.:.:.::||
  Fly   684 YEHAQKIIDNPNERFTENDFPTILNGFNPDDIRNRVLWLHDIASSIRKTRLDNGALTINNAKLRF 748

  Fly   647 QVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVK 711
            .:|..|.|||..||::.||.|.::||||||||..||..|...|.:.||||.||       .||:|
  Fly   749 LLDPITGEPLSFEVEKQREANRLIEEFMLLANQAVARFIHDSFPDIAVLRNHP-------PPLIK 806

  Fly   712 SAR-------YQGFQVDINSGLELSHSLDK-CVKADNPY-FNTMIRILTTRCMMQAVYFIS-GSL 766
            |.:       ..||::|.:|...|..|:.: |.:|.||. .|..:..|..:.|.:|.||.| |..
  Fly   807 SLKALREKLLALGFELDYSSSKALQESMVRLCNEAPNPVAMNACLSQLLMKPMARATYFCSEGKS 871

  Fly   767 QKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNL----N 827
            :..:.:||.|:.|||||||||||||.||:|||||||::    .|.....|..::  .|.|    |
  Fly   872 EPADLWHYALSIPIYTHFTSPIRRYPDILVHRLLAAAL----KYCTPPKRTPDD--LHTLTKLAN 930

  Fly   828 YRHKMAQYAGRASVALNTHLFFRGKE-------------------EDEEGYVLFVRKNALQVLIP 873
            .|...|:.||..|..|....:...|:                   ..|.|:|:.:.....:||:.
  Fly   931 ERKYNAKKAGEDSGNLYFKRYVHNKQGIYMRAVVIEIFQHMMNVVTLESGHVISINYKMQKVLVD 995

  Fly   874 KYGL 877
            .:|:
  Fly   996 THGV 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	25/136 (18%)
		VacB	249..945	CDD:223631	218/727 (30%)
		RNB	474..802	CDD:279157	142/354 (40%)
Dis3l2	NP_728490.1	VacB	420..986	CDD:223631	191/587 (33%)
Dis3l2	NP_728490.1	RNB	560..909	CDD:279157	144/356 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468445
Domainoid	1	1.000	173	1.000	Domainoid score	I154
eggNOG	1	0.900	-	-		E1_COG0557
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	1	1.000	-	-		otm51468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850