Protein Alignment Dis3 and Dis3l2

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_728490.1
• Gene: Dis3l2 / 38034
• FlyBaseID: FBgn0035111
• Length: 1044
• Species: Drosophila melanogaster
• Alignment Length: 914
• Identity: 252/914 - (27%)
• Similarity: 404/914 - (44%)
• Gaps: 190/914 - (20%)

  Fly    83 LRN-VVVLTTVLNEVKHRSSAIYK------RFNEIVHDRTRNFYVFVNEHHKETYADREPDET-- 138
            ||| |..|..::..:.|.|..:..      |.|||:...          ...:|.::..|.:.
  Fly   157 LRNEVEALQDMVKHLSHLSPDVNAYACQLIRKNEILSQL----------EWSQTRSEAHPQQVGY 211

  Fly   139 -ANDRNDRAIRLATKWYDDHLQ-------ASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGI 195
             ...|:|..:.....  ..|:|       ..::||:.:.||...|:          ..|.|.|.:
  Fly   212 QGRHRHDSEVSATNN--GSHVQQQPKLGRRQRNSKKNDGSGSNGTQ----------SQKTELEAM 264

  Fly   196 LVTTAAEYVKSLEDFPLLMDKLSHKTFDSE----KNGLPQYPPHLSMKELLEGLRQNKLLQGTFQ 256
                 ..|:..:....:.||   |:.  ||    |........|   .:.|......::::...:
  Fly   265 -----RSYINKIVQRHVGMD---HQL--SEDLIFKGNFSDLEAH---AQRLVAAGYGRIVEEEIR 316

  Fly   257 ASRENYLEGTVNVEKFEKGILIQGRESLNR------------AVDGDLV-AVELLPEAEWSA--- 305
            .:|:|..:..:        |:...||:|.|            |.|||.| |..|.|.|:.|:
  Fly   317 VNRKNNRQAFI--------IMSTDREALERDGIVLLPVARRYAFDGDKVRAFVLNPGAQGSSKTA 373

  Fly   306 -PS---------EIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRR-K 359
             ||         .:.|.:....:|:..|:....|.:.::      .:|::..|...::.|.:| :
  Fly   374 EPSSGEISGGKPSLSLADGEELSDDTESQGSESDTDNVV------VISSDNCPKAFVIAITKRTE 432

  Fly   360 WRQYCGILQ----PSLIEDTNRHIFVPADRKIPRIRI-ETRQAAMLQN-QRI----------IVT 408
            .||..|.:.    ..|.:|...:.|.|.|.::|.:.: :...||.:.| |:|          |:.
  Fly   433 LRQIVGTISFTNPTKLCDDQLFYKFRPYDLRVPMVYVPKDACAAHIGNKQQIDVSGLLYLAHILE 497

  Fly   409 IDTWPRNSRYPHGH----FVRSLGPLGDMATENEVILLEHDVPHCK-FSDEVLSFLPKMPWTITD 468
            .|.        :||    .::.:|.:|::..|.:.||..:.:...| |....:....:.|..|:.
  Fly   498 TDC--------NGHCIAELIQPVGRVGNLDDELKAILFHNGLRDIKPFEQRFIDIYSQPPPPISQ 554

  Fly   469 EDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAAR 533
            ||..:|.|||.:.|.::||....|:|||:..::|.:...|:||||:|||||:...|.||.....|
  Fly   555 EDLRQRKDLRKMCIFTIDPMTARDLDDAVSIEKLGDNEYEIGVHISDVSHFLIEDNELDNIVKER 619

  Fly   534 GTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKR--FHKSVIKSKRAMT 596
            .|::||..:.|.|:|:.|... |||:.|.::||||..|.::.:..:|.|:  |.::||.|.....
  Fly   620 STSIYLANEVIHMLPQSLCMR-CSLLPGQDKFAFSVFWRMNGKGVMLQKKPEFCRTVINSCSQFA 683

  Fly   597 YEEAQNIIDDATQ---QNEI--------AKSLRN----LNRLAKILKKRRMDNGALVLASPEIRF 646
            ||.||.|||:..:   :|:.        ...:||    |:.:|..::|.|:|||||.:.:.::||
  Fly   684 YEHAQKIIDNPNERFTENDFPTILNGFNPDDIRNRVLWLHDIASSIRKTRLDNGALTINNAKLRF 748

  Fly   647 QVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVK 711
            .:|..|.|||..||::.||.|.::||||||||..||..|...|.:.||||.||       .||:|
  Fly   749 LLDPITGEPLSFEVEKQREANRLIEEFMLLANQAVARFIHDSFPDIAVLRNHP-------PPLIK 806

  Fly   712 SAR-------YQGFQVDINSGLELSHSLDK-CVKADNPY-FNTMIRILTTRCMMQAVYFIS-GSL 766
            |.:       ..||::|.:|...|..|:.: |.:|.||. .|..:..|..:.|.:|.||.| |..
  Fly   807 SLKALREKLLALGFELDYSSSKALQESMVRLCNEAPNPVAMNACLSQLLMKPMARATYFCSEGKS 871

  Fly   767 QKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNL----N 827
            :..:.:||.|:.|||||||||||||.||:|||||||::    .|.....|..::  .|.|    |
  Fly   872 EPADLWHYALSIPIYTHFTSPIRRYPDILVHRLLAAAL----KYCTPPKRTPDD--LHTLTKLAN 930

  Fly   828 YRHKMAQYAGRASVALNTHLFFRGKE-------------------EDEEGYVLFVRKNALQVLIP 873
            .|...|:.||..|..|....:...|:                   ..|.|:|:.:.....:||:.
  Fly   931 ERKYNAKKAGEDSGNLYFKRYVHNKQGIYMRAVVIEIFQHMMNVVTLESGHVISINYKMQKVLVD 995

  Fly   874 KYGL 877
            .:|:
  Fly   996 THGV 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	25/136 (18%)
		VacB	247..946	CDD:440323	218/729 (30%)
Dis3l2	NP_728490.1	OB_Dis3	454..530	CDD:436091	18/83 (22%)
		RNB	560..909	CDD:459934	144/356 (40%)