DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and Dis3l2

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001102477.2	Gene:	Dis3l2 / 367307	RGDID:	1560168	Length:	890	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	266/877 - (30%)
Similarity:	420/877 - (47%)	Gaps:	152/877 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 KLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQG 280
            |..:|:...:|..:  :..::|.:::.|||::..|:||..:.:.:.:.|..:.....::.|.|.|
  Rat    36 KSKNKSMRGKKKSI--FETYMSKEDVSEGLKKGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDG 98

  Fly   281 RESLNRAVDGDLVAVELLPEAEW------SAPSEIVLE-------EKNVYA-------------- 318
            ..:.|||::||||.|:||||.:|      |.|..:.|:       :|...|
  Rat    99 VVARNRALNGDLVVVKLLPEDQWKPRITLSLPGVLGLQGVKPESNDKETEATNETDISEESCGHH 163

  Fly   319 --------------------DEVPSEER------------------------------AKDENEM 333
                                |:..||:|                              .||||..
  Rat   164 LLQKSPKGWNGPDVIIEAQFDDSDSEDRHGNTSGLVDGMKKLSVCTPDKGKEDSSAPVMKDENTP 228

  Fly   334 LNQVRAAALSAERTPTGRIVGIVRRKW-RQYCGILQPSLIEDTNRH------IFVPADRKIPRIR 391
            .:|...|........:.::|.|:.:|. |...|||:  |:.|.|..      :|.|:|.::|||.
  Rat   229 KSQDTRALSEKSLQKSAKVVYILEKKHSRAATGILK--LLADKNSDLFKKYALFSPSDHRVPRIY 291

  Fly   392 IETRQAAM--------LQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPH 448
            :..:....        ..|...|..|..|..:..:..|...:|||..|::..|.|.||.|:.|..
  Rat   292 VPLKDCPQDFMTRPKDYANTLFICRIIDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDF 356

  Fly   449 CKFSDEVLSFLPK-MPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVH 512
            ..||.|||..||: :||||..|:..||.|||...|.::||....|:||||.|::|.:|..|||||
  Rat   357 SDFSSEVLECLPQSLPWTIPPEEVGKRRDLRKDCIFTIDPSTARDLDDALSCRQLTDGTFEVGVH 421

  Fly   513 IADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEA 577
            |||||:|:..|::||..||.|.|:||||.|.:.|:|.||...||||....::..||.:|::..|.
  Rat   422 IADVSYFVPEGSSLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMTDKLTFSVIWKLTPEG 486

  Fly   578 NVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQ---------------NEIAKSLRNLNRLAKIL 627
            .:|.:.|.:::|:|...::|:.||::|::.|::               .|:.:::.||:.:||.|
  Rat   487 KILEEWFGRTIIRSCTKLSYDHAQSMIENPTEKIPKEELPPISPEHSIEEVHQAVLNLHSIAKQL 551

  Fly   628 KKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSEC 692
            :::|..:|||.|...::.|.:|.||..|....:.:.|::|.:|||||||||:.||..|...|.|.
  Rat   552 RRQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQ 616

  Fly   693 AVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILT---TRC 754
            |:|||||.|.......||:.....|..:|::|...|:.||.... .|:.|......:||   :|.
  Rat   617 ALLRRHPPPQTKMLSDLVEFCDQMGLPMDVSSAGALNKSLTNTF-GDDKYSLARKEVLTNMYSRP 680

  Fly   755 MMQAVYFISGSLQKE-EFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLD--- 815
            |..|:||.||.||.: :|.||.|..|:||||||||||::|::|||||||::|    |::..|
  Rat   681 MQMALYFCSGMLQDQAQFRHYALNVPLYTHFTSPIRRFADVIVHRLLAAALG----YSEQPDVEP 741

  Fly   816 --RKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFR--GKEE---DEEGYVLFVRKNALQVLIP 873
              .:...:.|::.....|..|       .|:..|||.  .||.   :.|..|:.|...|..||:.
  Rat   742 DALQKQADHCNDRRMASKRVQ-------ELSIGLFFSILVKESGPLESEAMVMGVLNQAFDVLVL 799

  Fly   874 KYGLEGTLY-----LKS---DKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSL 930
            ::|::..:|     |:|   .|.||      |.|:...:..:|..:.....|...|..|.|.|..
  Rat   800 RFGVQKRIYCNALALRSYHFQKVGK------KPELTLVWEPDDLEEEPIQQVITIFSLVDVVLQA 858

  Fly   931 DSSNVQHEKLIFRLVKPYIKGFSVETTTEGTD 962
            :::.:::..::.|....:..|...|:..|..|
  Rat   859 EATALKYSAILKRPGPEHSLGLEKESDEEPED 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032
		VacB	249..945	CDD:223631	255/825 (31%)
		RNB	474..802	CDD:279157	140/346 (40%)
Dis3l2	NP_001102477.2	Rrp44_CSD1	50..>159	CDD:375054	29/108 (27%)
Dis3l2	NP_001102477.2	VacB	238..824	CDD:223631	209/599 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920