DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and Dis3l

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001008381.2	Gene:	Dis3l / 363077	RGDID:	1308959	Length:	1054	Species:	Rattus norvegicus

Alignment Length:	1028	Identity:	349/1028 - (33%)
Similarity:	540/1028 - (52%)	Gaps:	149/1028 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQ 74
            :|.:|..|:||||||||..:.|.|.||.:       ..|.::..|....:..||::.|..||.|.
  Rat    12 RTFQGRTLRIVREHYLRPSVPCNSPLCPQ-------PATCRNDGKLLSAEVTHYVIPDWKVVQDY 69

  Fly    75 IDVLEEDVLRNVVVLTTVLNEVKH-RSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDET 138
            ::|||...|:.::.:.|....|:| |....|.:...::.|...:..:|.||..:..|..||..|.
  Rat    70 LEVLEFPELKGIIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCVLFANEFQQHCYLPREKGEA 134

  Fly   139 ANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDD--AANRAKAEAEGILVTTAA 201
            ......|:|..:..||..|.:....             :|::|:|  |..:..:|.||:.|.:..
  Rat   135 MEKWQTRSIYNSAVWYYHHCEDRMP-------------IVMVTEDEEAIQQYGSETEGVFVISFK 186

  Fly   202 EYVKSLEDF-PLLMDKLSHKTFDS-------------EKNGLPQYPPHLSMKELLEGLRQNKLLQ 252
            .|   |::| |.|  |.:|:..||             |.:| .:||.||.::.|..|::..:.:|
  Rat   187 NY---LDNFWPDL--KAAHELCDSIIQSRRERESESQETHG-KEYPEHLPLEVLEAGIKSGRYIQ 245

  Fly   253 GTFQASRENYLEGTVNVEKFEK-------------GILIQGRESLNRAVDGDLVAVELLPEAEWS 304
            |....::..     ..:|.|.:             .|||.|.::.||::.||:|.|||||::||.
  Rat   246 GILNVNKHR-----AQIEAFVRLQGASSKDSGLVSDILIHGSKARNRSIHGDVVVVELLPKSEWK 305

  Fly   305 APSEIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQP 369
            ..:..:.|.        .||::|..|:           .:|..||||:|||:::.||.|. :..|
  Rat   306 GRTAALCEN--------DSEDKASGES-----------PSEPMPTGRVVGILQKNWRDYV-VTFP 350

  Fly   370 SLIE------DTNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLG 428
            |..|      :..:.:..|.|.:||:|||.|:||..||:.|::|.||:|...|.||:|||||.||
  Rat   351 SKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAEALQDFRVVVRIDSWETTSVYPNGHFVRVLG 415

  Fly   429 PLGDMATENEVILLEHDVPHCKFSDEVLSFLP----KMPWTITDEDYSKRVDLRDLY-ICSVDPP 488
            .:||:..|...||:|:.:....||:..:..:|    :.||.::.::..:|.|||..: :.|:||.
  Rat   416 RIGDLEGEIATILVENSINVVPFSEAQMCEMPVNTAENPWKVSPKEEQERRDLRSTHLVFSIDPK 480

  Fly   489 GCTDIDDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSS 553
            ||.|:||||..:.|.|||||:|||||||:||:.|.:.:|:||..|.||.||..:|.||:|.:||:
  Rat   481 GCEDVDDALSVRTLNNGNLELGVHIADVTHFVAPNSYIDVEARTRATTYYLADRRYDMLPSILSA 545

  Fly   554 NLCSLVGGVERFAFSCVWEVDNEANVLSKRFH-KSVIKSKRAMTYEEAQ-------NIIDD---- 606
            :||||:|||:|:|.|.:||:|..:..:.|.:: :::|:|...:.||.||       :|:||
  Rat   546 DLCSLLGGVDRYAVSVMWELDKTSYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNFSIVDDIPEF 610

  Fly   607 --ATQQNEIAK------SLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSE--THEPLEVEVK 661
              ..:||..||      ::..|..:|:.::.:|...|||.|...|:|.|:|.:  .|:.:.   |
  Rat   611 KTLEEQNRQAKLEELVWAIGKLTDIARHIRAKRDRCGALELEGVEVRVQLDDKKNIHDLIP---K 672

  Fly   662 QMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGL 726
            |..|.:..|.|.|:|||..||:.|...|...|:||:||.|....|..|.:.|:.:||.:|..|..
  Rat   673 QPLEVHETVAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNK 737

  Fly   727 ELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRY 791
            .|:.|||......:|..|.::|.:.|:.|..|:||.:||..:|||.|||||...|||||||||||
  Rat   738 TLADSLDSANDPSDPLVNKLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSPIRRY 802

  Fly   792 SDIMVHRLLAASIGADSTY---AQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKE 853
            |||:|||||.|:|..|...   ..|...|:.||||.::|.|::.||.:.:.|..|...::|:.::
  Rat   803 SDIVVHRLLMAAISKDKKVEIKENLFSNKNLEELCRHINNRNRAAQRSQKQSTELFQCMYFKDRD 867

  Fly   854 EDEE------GYVLFVRKNALQVLIPKYGLEGTLYLKSDKDG-------------KDG-VERVKS 898
            .:.|      |.:..:|.|.:.|.||::|::|..||| :|||             |.| ::|.::
  Rat   868 PETEERCVVDGIIYSIRTNGVLVFIPRFGIKGAAYLK-NKDGLVISCGPEGSSEWKPGSLQRSQN 931

  Fly   899 EIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLV--KPYI 949
            :|:.|      |.....|.||.||.||||:|:..|....:.:...:|  |||:
  Rat   932 KIIST------TAGGQSVTFHLFDHVTVRISVQPSRCHSDMIRLEIVSNKPYM 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	53/195 (27%)
		VacB	249..945	CDD:223631	275/764 (36%)
		RNB	474..802	CDD:279157	150/350 (43%)
Dis3l	NP_001008381.2	PIN_Rrp44-like	11..188	CDD:350211	53/195 (27%)
		VacB	265..899	CDD:223631	247/656 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..332		7/37 (19%)
		Rrp44_S1	881..958	CDD:407336	29/83 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1261
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920