DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and Dis3

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001120955.1	Gene:	Dis3 / 306103	RGDID:	1304646	Length:	957	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	542/993 - (54%)
Similarity:	705/993 - (70%)	Gaps:	58/993 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHA----------NKSTLFK 59
            :.|.:||:.|.::|||||||||||||||:..|..|        .:.||          ..|:|..
  Rat     5 KTFLKKTRAGGVVKIVREHYLRDDIGCGTPACSAC--------GAAHAGPALELQPRDQASSLCP 61

  Fly    60 FPHYLVLDTNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNE 124
            :||||:.||||:|.||||||:..:|||:||.|||.||::||:.||||..::.:::.::||.|.||
  Rat    62 WPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPIYKRIRDVTNNQEKHFYTFTNE 126

  Fly   125 HHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAK 189
            ||||||.::|..|.||||||||||:|.|||::||:.|..::         .:|:|:|:|..|:.|
  Rat   127 HHKETYIEQEQGENANDRNDRAIRVAAKWYNEHLKMSAENQ---------LQVILITNDKKNKEK 182

  Fly   190 AEAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQ----YPPHLSMKELLEGLRQNKL 250
            |..|||...|..||||||...|.|:|:|:  ....|.|.:..    :..||.:.:|.:|::....
  Rat   183 AAEEGIPAFTCEEYVKSLTANPELIDRLA--CLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSY 245

  Fly   251 LQGTFQASRENYLEGTVNV---EKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLE 312
            |||||:||||||||.||.:   ::.||.|||||.:.||||:..|:|||||||:::|.|||.:||.
  Rat   246 LQGTFRASRENYLEATVWIHGDKEDEKEILIQGLKHLNRAIHEDIVAVELLPKSQWVAPSSVVLH 310

  Fly   313 EKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNR 377
            ::....|:|..:|    |.|:|  ::.|.......||||:|||::|.||.|||:|..|.|:::.|
  Rat   311 DEGQNEDDVEKDE----ERELL--LKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESRR 369

  Fly   378 HIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILL 442
            |:|.|||::|||||||||||:.|:.:||||.||.||||||||:||||::||.:|:..||.||:||
  Rat   370 HLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLL 434

  Fly   443 EHDVPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNL 507
            ||||||..||..||||||||||:||:||...|.|||.|.:|||||||||||||||||:||.||||
  Rat   435 EHDVPHQPFSQAVLSFLPKMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNL 499

  Fly   508 EVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWE 572
            ||||||||||||||||||||.|:|.|||||||..|||||||||||||||||...|:|.||||:||
  Rat   500 EVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWE 564

  Fly   573 VDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGAL 637
            :::.|.:|..||.||||.||.::||.|||..||.|...::|..|||.||:||||||:.|::.|||
  Rat   565 MNHNAEILKTRFTKSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNKLAKILKRGRIEKGAL 629

  Fly   638 VLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPP 702
            .|:||||||.:|||||:|::::.|::||||||||||||||||:||:.|..||||.|:||:||.||
  Rat   630 TLSSPEIRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPP 694

  Fly   703 PTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQ 767
            |:|::.|||:|:.:..::..::...|:.|||:....|.||.||::|||.||||||||||.||  .
  Rat   695 PSNYEVLVKAAKSKNLEIRTDTAKSLADSLDRAECPDFPYLNTLLRILATRCMMQAVYFCSG--M 757

  Fly   768 KEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKM 832
            ..:|.|||||:|||||||||||||:||:||||||.:||||.||.:|.|:....::|.|||:||||
  Rat   758 DSDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADCTYPELTDKHKLSDICKNLNFRHKM 822

  Fly   833 AQYAGRASVALNTHLFFRGKE-EDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERV 896
            ||||.|||||.:|.|||:.|. ..||.|:|||||||:.|||||||||||::.:         |:.
  Rat   823 AQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFE---------EKD 878

  Fly   897 KSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGT 961
            |.:...|:::|..:.|....|||.||.|.|:::|||||:||:|:...||:|.|.|.::.......
  Rat   879 KPKPRLTYDDEIPSLRIEGTVFHVFDKVKVKITLDSSNLQHQKIRMALVEPQIPGINMPPDVSDM 943

  Fly   962 DSQAVSAAPPSKKTKKDK 979
            |..    .|..||.|.:|
  Rat   944 DLN----GPGGKKRKLEK 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	96/203 (47%)
		VacB	249..945	CDD:223631	418/699 (60%)
		RNB	474..802	CDD:279157	216/327 (66%)
Dis3	NP_001120955.1	PIN_Rrp44	9..196	CDD:189032	94/196 (48%)
		VacB	194..929	CDD:223631	429/742 (58%)
		RNB	466..794	CDD:279157	213/327 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352701
Domainoid	1	1.000	442	1.000	Domainoid score	I515
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6910
Inparanoid	1	1.050	1046	1.000	Inparanoid score	I246
OMA	1	1.010	-	-		QHG53920
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	1	1.000	-	-		oto98837
orthoMCL	1	0.900	-	-		OOG6_101226
Panther	1	1.100	-	-	LDO	PTHR23355
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1261
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770