Protein Alignment Dis3 and dis3

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_596653.1
• Gene: dis3 / 2540398
• PomBaseID: SPBC26H8.10
• Length: 970
• Species: Schizosaccharomyces pombe
• Alignment Length: 960
• Identity: 420/960 - (43%)
• Similarity: 575/960 - (59%)
• Gaps: 62/960 - (6%)

  Fly     5 REFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQ--------NEVYQLTSQHANKSTLFKF- 60
            |.|.|.| ||.:.|:|||.|||:||.|.|..|..|..        |.:..:.|:  ....|.||
pombe    20 RVFVRAT-RGKVQKVVREQYLRNDIPCQSRACPLCRSKLPKDSRGNVLEPILSE--KPMFLEKFG 81

  Fly    61 PHYLVLDTNVVLDQIDVLEE-DVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNE 124
            .|||:.|:|:....||.||. :...:|::|.||.:|:..:|..:|.|...:..::|:.|..|.||
pombe    82 HHYLIPDSNIFYHCIDALEHPNNFFDVIILQTVFSEISSKSIPLYNRMKRLCQEKTKRFTPFSNE 146

  Fly   125 HHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAK 189
            ...:|:.:|..||:||||||||||.|..|:..||            .....::||||||..|...
pombe   147 FFVDTFVERLDDESANDRNDRAIRNAASWFASHL------------ASLGIKIVLLTDDRENARL 199

  Fly   190 AEAEGILVTTAAEYVKSLEDFPLLMDKLS---------HKTFDSEKNGLPQYPPHLSMKELLEGL 245
            |..:||.|:|..:||:.|.|..:|:|.:|         .:.....||   .|..|.||..||..:
pombe   200 AAEQGIQVSTLKDYVQYLPDSEILLDMVSAIADAIASKEQVESGTKN---VYELHWSMSRLLACI 261

  Fly   246 RQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIV 310
            :..::.:|....|..|||||:|.|..:.|.:|:.|||:|||||.||:|.:::||:.:|...:|.:
pombe   262 KNGEVHKGLINISTYNYLEGSVVVPGYNKPVLVSGRENLNRAVQGDIVCIQILPQDQWKTEAEEI 326

  Fly   311 LEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERT--PTGRIVGIVRRKWRQYCGILQPSLIE 373
            .::.    ::|.....|:.::..:|.:.   |..:|.  ||.::|||::|.||.|.|.:..:.|.
pombe   327 ADDD----EDVVVSTAAEPDSARINDLE---LITKRNAHPTAKVVGILKRNWRPYVGHVDNATIA 384

  Fly   374 DT-----NRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDM 433
            .:     ...:..|.||::|:||..||||..|..:||:|.||.|..:||||.|||||.||.:...
pombe   385 QSKGGSQQTVLLTPMDRRVPKIRFRTRQAPRLVGRRIVVAIDLWDASSRYPEGHFVRDLGEMETK 449

  Fly   434 ATENEVILLEHDVPHCKFSDEVLSFLP------KMPWTITDEDYSKRVDLRDLYICSVDPPGCTD 492
            ..|.|.:|||:||.|..|...||..||      |:|...|...:..|.|.||..|||:|||||.|
pombe   450 EAETEALLLEYDVQHRPFPKAVLDCLPEEGHNWKVPADKTHPLWKNRKDFRDKLICSIDPPGCQD 514

  Fly   493 IDDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCS 557
            ||||||...|||||.|||||||||:||::|..::|.|||:||||||||.|||||:|.||.::|||
pombe   515 IDDALHACVLPNGNYEVGVHIADVTHFVKPNTSMDSEAASRGTTVYLVDKRIDMLPMLLGTDLCS 579

  Fly   558 LVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNR 622
            |...||||||||:||:|..||::...|.||||.||.|.:|.:||..|||...|:.:.:.:|.|.:
pombe   580 LRPYVERFAFSCIWEMDENANIIKVHFTKSVIASKEAFSYADAQARIDDQKMQDPLTQGMRVLLK 644

  Fly   623 LAKILKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIAT 687
            |:||||::|||.|||.|||||:|.|.|:||.:|::||:||:.||||:||||||||||:||:.|..
pombe   645 LSKILKQKRMDEGALNLASPEVRIQTDNETSDPMDVEIKQLLETNSLVEEFMLLANISVAQKIYD 709

  Fly   688 EFSECAVLRRHPRPPPTNFDPLVKSARY-QGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILT 751
            .|.:.||||||..||.||||.|....|. :|..:..::...|:.|||:||....|||||::||||
pombe   710 AFPQTAVLRRHAAPPLTNFDSLQDILRVCKGMHLKCDTSKSLAKSLDECVDPKEPYFNTLLRILT 774

  Fly   752 TRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDR 816
            ||||:.|.||.||:....:|.|||||:|||||||||||||:|::.||.|||:|..::....|.|:
pombe   775 TRCMLSAEYFCSGTFAPPDFRHYGLASPIYTHFTSPIRRYADVLAHRQLAAAIDYETINPSLSDK 839

  Fly   817 KSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTL 881
            ....|:|:.:||||:|||.|||||:........:|...:|:.||:.|.||...|.|.::||||.:
pombe   840 SRLIEICNGINYRHRMAQMAGRASIEYYVGQALKGGVAEEDAYVIKVFKNGFVVFIARFGLEGIV 904

  Fly   882 YLKS-DKDGKDGVERVKSEIVFTFNEEDHTQ-RCGDVVFHSFDPVTVRLS 929
            |.|| ....:..||.|:.|  :..|.|...| :...|....|..|.||::
pombe   905 YTKSLSSVLEPNVEYVEDE--YKLNIEIRDQPKPQTVQIQMFQQVRVRVT 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	74/203 (36%)
		VacB	247..946	CDD:440323	329/699 (47%)
dis3	NP_596653.1	PIN_Rrp44-like	27..213	CDD:350211	72/199 (36%)
		Rrp44_CSD1	251..370	CDD:375054	41/125 (33%)
		OB_Dis3	394..461	CDD:436091	33/66 (50%)
		RNB	496..827	CDD:459934	198/330 (60%)
		Rrp44_S1	877..966	CDD:435792	27/78 (35%)